Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Pureza:95%Cor e Forma:LiquidPOL1-IN-1
CAS:POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。Fórmula:C21H20N6Pureza:98%Cor e Forma:SolidPeso molecular:356.42Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activationFórmula:C76H121N19O25SPureza:98.96%Cor e Forma:SolidPeso molecular:1732.95CAF-382
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinityFórmula:C16H22N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:366.5PD-L1-IN-3
CAS:PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Fórmula:C19H15ClFN2OSPureza:99.47%Cor e Forma:SoildPeso molecular:373.85DHX9-IN-2
CAS:DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.Fórmula:C18H16ClN3O3S2Pureza:98.00%Cor e Forma:SolidPeso molecular:421.92β-glycosidase-IN-1
CAS:β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.Fórmula:C13H23NO5Pureza:98%Cor e Forma:SolidPeso molecular:273.33Orotic acid
CAS:Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.Fórmula:C5H4N2O4Pureza:99.42%Cor e Forma:Crystals Physical Description White Crystals Or Crystalline Powder (Ntp 1992)Peso molecular:156.1IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Fórmula:C16H12BrClFNO4Pureza:99.56%Cor e Forma:SolidPeso molecular:416.63BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Fórmula:C12H9BrN2OSPureza:99.91% - ≥95%Cor e Forma:SolidPeso molecular:309.18Ref: TM-T9033
5mg48,00€10mg63,00€25mg93,00€50mg136,00€100mg198,00€200mg309,00€500mg563,00€1mL*10mM (DMSO)50,00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.45% - 98.43%Cor e Forma:SolidPeso molecular:475.42PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Fórmula:C24H37N3O4Pureza:99.25%Cor e Forma:SoildPeso molecular:431.57Ref: TM-T60101
1mg52,00€5mg111,00€10mg180,00€25mg305,00€50mg439,00€100mg612,00€1mL*10mM (DMSO)124,00€RdRP-IN-6
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM.Fórmula:C41H67N8O7PSi2Pureza:98%Cor e Forma:SolidPeso molecular:871.16Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.16%Cor e Forma:SolidPeso molecular:499.5Ref: TM-TQ0291
1mg47,00€5mg87,00€10mg140,00€25mg283,00€50mg464,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)97,00€Pacmilimab
CAS:Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Pureza:95% - 95%Cor e Forma:LiquidNUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C25H30N6OCor e Forma:SolidPeso molecular:430.545MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Cor e Forma:SolidPeso molecular:476.86Ref: TM-T6315
1mg52,00€2mg71,00€5mg88,00€10mg127,00€25mg233,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)93,00€2,5-Di-tert-butyl-1,4-benzoquinone
CAS:2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.Fórmula:C14H20O2Cor e Forma:SolidPeso molecular:220.31AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM),具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶,在细胞周期中对 DNA 复制的启动至关重要。Fórmula:C21H22F3N5O4Pureza:100%Cor e Forma:SolidPeso molecular:465.43DI-87
CAS:DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor. DI-87 binds to dCK reduces the production of dNTP inhibits tumor growth.Fórmula:C23H30N6O3S2Pureza:99.76%Cor e Forma:SolidPeso molecular:502.65Levoleucovorin Calcium
CAS:Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.Fórmula:C20H21N7O7·CaPureza:98.46% - ≥98%Cor e Forma:White Crystalline PowderPeso molecular:511.5PROTAC CDK9 degrader-6
CAS:PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Fórmula:C42H49Cl2N9O8Pureza:98%Cor e Forma:SolidPeso molecular:878.8THZ1-R
CAS:THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).Fórmula:C31H30ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:568.07CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Fórmula:C24H16FN5OCor e Forma:SolidPeso molecular:409.42Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Cor e Forma:LiquidCDK-TCIP2
DK-TCIP2 is an anticancer agent formed by linking the CDK9 inhibitor SNS-032 and the BCL6 inhibitor BI-3812. This compound exhibits anticancer activity both in vivo and in vitro, making it suitable for research in lymphoma.Fórmula:C52H67ClN12O8S2Cor e Forma:SolidPeso molecular:1087.75SIBA
CAS:SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.Fórmula:C14H21N5O3SPureza:99.48%Cor e Forma:SolidPeso molecular:339.41Ref: TM-T12908
1mg52,00€5mg94,00€10mg117,00€25mg220,00€50mg329,00€100mg469,00€200mg652,00€1mL*10mM (DMSO)104,00€(R)-Simurosertib
CAS:(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Fórmula:C17H19N5OSPureza:99.64%Cor e Forma:SolidPeso molecular:341.43JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.66%Cor e Forma:SolidPeso molecular:394.36Ref: TM-T6126
1mg50,00€2mg66,00€5mg105,00€10mg180,00€25mg284,00€50mg520,00€100mg728,00€500mg1.473,00€1mL*10mM (DMSO)88,00€2'-Deoxy-2'-fluorocytidine
CAS:2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.Fórmula:C9H12FN3O4Pureza:99.03%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:245.21Bleomycin hydrochloride
CAS:Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.Fórmula:C55H84ClN17O21S3Pureza:98%Cor e Forma:SoildPeso molecular:1451.01(Average)Mithramycin A
CAS:Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of variousFórmula:C52H76O24Pureza:99.28%Cor e Forma:Yellow PowderPeso molecular:1085.15CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:97.06% - 99.69%Cor e Forma:SolidPeso molecular:379.34Ref: TM-T7080
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg225,00€50mg369,00€100mg552,00€1mL*10mM (DMSO)92,00€DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFórmula:C14H9Cl2N3O4SPureza:98%Cor e Forma:SolidPeso molecular:386.21IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Fórmula:C13H11Cl2NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:316.14Ref: TM-T40419
1mg103,00€5mg246,00€10mg395,00€25mg785,00€50mg1.198,00€100mg1.853,00€200mg2.498,00€1mL*10mM (DMSO)271,00€STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Fórmula:C15H11NO3S2Pureza:97.53% - 98.85%Cor e Forma:SolidPeso molecular:317.38Ref: TM-T6681
5mg51,00€10mg80,00€25mg120,00€50mg205,00€100mg368,00€200mg555,00€500mg810,00€1mL*10mM (DMSO)58,00€ARB-272572
CAS:ARB-272572 is a PD-L1 signaling inhibitor that produces immunostimulatory activity in human primary cells.Fórmula:C32H36N6O4Pureza:97.36% - 98.07%Cor e Forma:SolidPeso molecular:568.675-Bromo-2',3',5'-tri-O-acetyluridine
CAS:5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that can be used to explore explore improve Parkinson's disease.Fórmula:C15H17BrN2O9Pureza:99%Cor e Forma:SolidPeso molecular:449.21(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Fórmula:C31H30Cl3N7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:638.98TASIN-1
CAS:TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).Fórmula:C18H28N2O3SPureza:98.48%Cor e Forma:SolidPeso molecular:352.49Ref: TM-T22632
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)92,00€GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Fórmula:C24H29Cl2N3OPureza:98.44%Cor e Forma:SolidPeso molecular:446.41Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Fórmula:C18H15N5OPureza:97.03%Cor e Forma:SolidPeso molecular:317.34Ref: TM-T21981
1mg64,00€2mg96,00€5mg145,00€10mg212,00€25mg353,00€50mg532,00€100mg792,00€200mg1.064,00€EHT 1864 2HCl
CAS:EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Fórmula:C25H29Cl2F3N2O4SPureza:98.39% - 99.42%Cor e Forma:SolidPeso molecular:581.47Ref: TM-T6483
1mg47,00€5mg92,00€10mg136,00€25mg259,00€50mg472,00€100mg677,00€200mg934,00€1mL*10mM (DMSO)107,00€(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFórmula:C72H99F3N20O23Pureza:98%Cor e Forma:SolidPeso molecular:1669.67H1k
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.Fórmula:C27H22N2OPureza:98.38%Cor e Forma:SoildPeso molecular:390.48Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Fórmula:C29H42N6O9Cor e Forma:SolidPeso molecular:618.68LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Fórmula:C29H48N12O12S2Pureza:100%Cor e Forma:SolidPeso molecular:820.89HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Fórmula:C19H23BrClN3O6Pureza:99.02% - 99.96%Cor e Forma:SolidPeso molecular:504.8Ref: TM-T8785
2mg42,00€5mg59,00€10mg94,00€25mg130,00€50mg207,00€100mg309,00€200mg462,00€1mL*10mM (DMSO)66,00€Amsilarotene
CAS:Amsilarotene (TAC101) blocks RB phosphorylation, boosts 2 CDK inhibitors, halts cell cycle, and reduces thymidylate synthase and cyclin A levels.Fórmula:C20H27NO3Si2Pureza:99.27%Cor e Forma:SolidPeso molecular:385.6Ref: TM-T21314
1mg43,00€2mg57,00€5mg96,00€10mg140,00€25mg273,00€50mg393,00€100mg560,00€200mg757,00€1mL*10mM (DMSO)96,00€ARRY 520 hydrochloride
CAS:'ARRY 520 hydrochloride: a KSP inhibitor causing apoptosis and strong anti-proliferative effects.'Fórmula:C20H23ClF2N4O2SPureza:98.06% - 99.26%Cor e Forma:SolidPeso molecular:456.94Ref: TM-TQ0318L
1mg59,00€5mg116,00€10mg170,00€25mg304,00€50mg437,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)149,00€
