Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Fórmula:C19H15ClFNO2SCor e Forma:SolidPeso molecular:375.84Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Cor e Forma:SolidPeso molecular:346.34Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Fórmula:C30H33Cl4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:641.41Ascamycin
CAS:Ascamycin: a Streptomyces-made antibiotic targeting Xanthomonas spp. MIC: 0.4-12.5 μg/mL for X. citri, oryzae, and phage.Fórmula:C13H18ClN7O7SPureza:99.29%Cor e Forma:SolidPeso molecular:451.84Ref: TM-T14329
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)747,00€(E/Z)-ZINC09659342
CAS:(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.Fórmula:C23H15F3N2O4Pureza:95.83%Cor e Forma:SolidPeso molecular:440.37Ref: TM-T9986
1mg66,00€5mg145,00€10mg221,00€25mg378,00€50mg533,00€100mg718,00€200mg938,00€1mL*10mM (DMSO)160,00€Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFórmula:C18H16O8Pureza:99.50% - 99.85%Cor e Forma:SolidPeso molecular:360.315-BrdU
CAS:5-BrdU (Broxuridine) , a nucleoside analog, are used in the detection of proliferating cells and competes with thymidine for incorporation into DNA.Fórmula:C9H11BrN2O5Pureza:99.54% - 99.87%Cor e Forma:Crystals From Absolute Ethanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:307.1Bersanlimab
CAS:Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:144.22 kDa5-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Fórmula:C8H12N4O5Pureza:99.31% - 99.79%Cor e Forma:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2(R)-Atuveciclib
CAS:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Fórmula:C18H18FN5O2SPureza:98%Cor e Forma:SolidPeso molecular:387.43αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Cor e Forma:SolidPeso molecular:672.67VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:98.31% - 99.72%Cor e Forma:SolidPeso molecular:400.04Ref: TM-T9168
1mg37,00€2mg52,00€5mg77,00€10mg96,00€25mg167,00€50mg240,00€100mg378,00€500mg889,00€1mL*10mM (DMSO)85,00€WRN inhibitor 15
WRN inhibitor 15 (Compound 9) is a WRN inhibitor with antitumor properties, displaying IC50 values of 37.9, 40.2, and 46.6 μM in PC3, LNCaP, and HeLa cells, respectively, making it suitable for prostate cancer research.Fórmula:C16H13F2N3OCor e Forma:SolidPeso molecular:301.29αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Cor e Forma:SolidPeso molecular:474.543'-Deoxy-3'-fluoroadenosine
CAS:3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with a wide range of anti-tumor and anti-viral activity, and has inhibitory effects on tick-borneFórmula:C10H12FN5O3Pureza:99.84%Cor e Forma:SolidPeso molecular:269.23Synucleozid hydrochloride
CAS:Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.Fórmula:C22H21ClN6Pureza:98.13%Cor e Forma:SolidPeso molecular:404.9CNDAC hydrochloride
CAS:CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.Fórmula:C10H13ClN4O4Pureza:99.69%Cor e Forma:SolidPeso molecular:288.69Ref: TM-T13621
1mg114,00€5mg274,00€10mg425,00€25mg702,00€50mg938,00€100mg1.311,00€1mL*10mM (DMSO)250,00€K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Fórmula:C13H15N3O2SPureza:100%Cor e Forma:SolidPeso molecular:277.34RX-3117
CAS:RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog.Fórmula:C10H12FN3O4Pureza:99.55%Cor e Forma:SolidPeso molecular:257.22Ref: TM-T16813
1mg157,00€2mg212,00€5mg309,00€10mg444,00€25mg728,00€50mg1.017,00€100mg1.378,00€1mL*10mM (DMSO)319,00€CDK7-IN-25
CAS:CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].Fórmula:C33H32N6O3Pureza:98%Cor e Forma:SolidPeso molecular:560.65Betamethasone 17-benzoate
CAS:Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).Fórmula:C29H33FO6Pureza:98%Cor e Forma:SolidPeso molecular:496.57CDK4-IN-2
CAS:CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Fórmula:C22H26F2N6O4SPureza:98%Cor e Forma:SolidPeso molecular:508.54CDK2-IN-20
CDK2-IN-20 (compound 3b), a CDK2 inhibitor, exhibits cytotoxic effects on tumor cells with an IC50 ranging from 5.52-17.09 µM.Pureza:98%Cor e Forma:Odour SolidCDK4/9-IN-1
CAS:CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.Fórmula:C22H34N6O2Cor e Forma:SolidPeso molecular:414.544Spartalizumab
CAS:"Spartalizumab (PDR001), a humanized IgG4 monoclonal antibody, targets PD-1 to inhibit PD-L1/L2 interactions, useful in ATC research."Pureza:SDS-PAGE:95.2%;SEC-HPLC:96.3%Cor e Forma:LiquidPeso molecular:145.74 kDaPurvalanol B
CAS:Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)Fórmula:C20H25ClN6O3Pureza:98.95%Cor e Forma:SolidPeso molecular:432.9Ref: TM-T7167
1mg38,00€5mg73,00€10mg95,00€25mg148,00€50mg215,00€100mg323,00€200mg487,00€1mL*10mM (DMSO)81,00€Visugromab
CAS:Visugromab, a GDF-15 neutralizing IgG4 monoclonal antibody (mAb), demonstrates potent efficacy in treating PD-1/PD-L1 relapsed/refractory metastatic solidPureza:98%Cor e Forma:LiquidN6-(p-Methoxybenzyl)adenosine
CAS:Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; plant growth regulator, plant hormoneFórmula:C18H21N5O5Pureza:99.79%Cor e Forma:SolidPeso molecular:387.39L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Fórmula:C5H13ClN2OSPureza:99.75%Cor e Forma:SolidPeso molecular:184.692'-O-(2-Methoxyethyl)adenosine
CAS:2'-O-(2-Methoxyethyl)adenosine is a nucleoside analog used to improve RNA target affinity and nuclease resistance of therapeutic oligonucleotides in preclin.Fórmula:C13H19N5O5Pureza:99.35%Cor e Forma:SolidPeso molecular:325.32Uridine triphosphate 13C9,15N2 sodium
CAS:Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.Fórmula:C9H1415N2NaO15P3Cor e Forma:SolidPeso molecular:517.04BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Fórmula:C22H20N4OPureza:96.7% - 99.43%Cor e Forma:SolidPeso molecular:356.42Ref: TM-T5405
1mg40,00€5mg88,00€10mg126,00€25mg240,00€50mg439,00€100mg647,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Nofazinlimab
CAS:Nofazinlimab (CS1003) is a human anti-PD-1 IgG4 monoclonal antibody for the study of unresectable hepatocellular carcinoma (uHCC).Cor e Forma:LiquidCDK9-IN-8
CAS:CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Fórmula:C31H32FN7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:569.63RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Cor e Forma:SolidPeso molecular:361.61Ganciclovir sodium
CAS:Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.Fórmula:C9H13N5NaO4Pureza:99.47%Cor e Forma:SolidPeso molecular:278.226-Hydroxy-DOPA
CAS:6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.Fórmula:C9H11NO5Pureza:96.59% - 97.23%Cor e Forma:SolidPeso molecular:213.19Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:100% - 99.82%Cor e Forma:SolidPeso molecular:500.6Ref: TM-T2077
5mg48,00€10mg70,00€25mg86,00€50mg92,00€100mg116,00€200mg170,00€500mg274,00€1mL*10mM (DMSO)52,00€Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of upPureza:98.6%Cor e Forma:LiquidPeso molecular:143.7 kDaGSK2850163 (S enantiomer)
CAS:GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a).Fórmula:C24H29Cl2N3OPureza:98.40%Cor e Forma:SolidPeso molecular:446.41Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Fórmula:C28H43N9O7Pureza:100%Cor e Forma:SolidPeso molecular:617.7LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.Fórmula:C23H29ClN8OPureza:100%Cor e Forma:SolidPeso molecular:469.02Ref: TM-T4417
1mg59,00€2mg85,00€5mg97,00€10mg172,00€25mg339,00€50mg502,00€100mg728,00€1mL*10mM (DMSO)97,00€GRGDSPK
CAS:GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Fórmula:C28H49N11O11Pureza:98%Cor e Forma:SolidPeso molecular:715.76ZNL-05-044
ZNL-05-044, a CDK11 inhibitor, exhibits IC50 values of 0.23 μM for CDK11A and 0.27 μM for CDK11B, as determined by NanoBRET assay.Fórmula:C21H22Cl2N6OSPureza:98%Cor e Forma:SolidPeso molecular:477.41MDEG-541
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].Fórmula:C35H38N4O7SPureza:98%Cor e Forma:SolidPeso molecular:658.76TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Fórmula:C27H34F3N7O3Pureza:97.06%Cor e Forma:SolidPeso molecular:561.6Ref: TM-T7200
1mg64,00€2mg89,00€5mg120,00€10mg170,00€25mg294,00€50mg490,00€100mg710,00€1mL*10mM (DMSO)170,00€BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Fórmula:C16H22N6OPureza:99.69%Cor e Forma:SolidPeso molecular:314.39Ref: TM-T23820
2mg52,00€5mg111,00€10mg175,00€25mg321,00€50mg512,00€100mg825,00€200mg1.111,00€1mL*10mM (DMSO)47,00€UNC9512
UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editingFórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64(E/Z)-Rigosertib sodium
CAS:ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay).Fórmula:C21H24NNaO8SPureza:97.16% - 99.82%Cor e Forma:SolidPeso molecular:473.47
