Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Fórmula:C23H25ClN8OSPureza:98.14%Cor e Forma:SolidPeso molecular:497.02Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:99.94%Cor e Forma:SolidPeso molecular:416.51p21PBP
p21PBP, a peptide composed of 20 amino acids, serves as an inhibitor of DNA replication. It specifically binds to the purified proliferating cell nuclear antigen (PCNA) found in extracts from tumor cells. p21PBP holds potential for use in cancer research.Fórmula:C112H181N37O30SCor e Forma:SolidPeso molecular:2557.93Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Fórmula:C14H11BrN4O3SPureza:98.38%Cor e Forma:SolidPeso molecular:395.23Ref: TM-T36933
1mg103,00€2mg140,00€5mg202,00€10mg305,00€25mg512,00€50mg730,00€100mg998,00€500mg1.977,00€IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Fórmula:C24H28N4O4Pureza:97.59% - 98.69%Cor e Forma:SolidPeso molecular:436.5YK-2168
CAS:YK-2168 is a differentiated selective inhibitor of CDK9.Fórmula:C16H18ClN5Cor e Forma:SolidPeso molecular:315.80PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Fórmula:C19H28N6O4Pureza:98.61%Cor e Forma:SolidPeso molecular:404.46Ref: TM-T9712
1mg354,00€2mg518,00€5mg823,00€10mg1.206,00€25mg1.795,00€50mg2.422,00€100mg3.258,00€1mL*10mM (DMSO)914,00€2'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.35%Cor e Forma:SolidPeso molecular:269.23BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:98.77% - 99.55%Cor e Forma:SolidPeso molecular:345.34Ref: TM-T2679
1mg35,00€5mg74,00€10mg116,00€25mg221,00€50mg335,00€100mg480,00€200mg652,00€1mL*10mM (DMSO)82,00€2'-Deoxy-5,6-dihydrouridine
CAS:2'-Deoxy-5,6-dihydrouridine is a nucleoside analog that contains a dihydro group in its molecular structure,commonly used in base excision related studies.Fórmula:C9H14N2O5Pureza:99.75%Cor e Forma:SolidPeso molecular:230.229-(β-D-Xylofuranosyl)adenine
CAS:9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine hasFórmula:C10H13N5O4Pureza:99.55%Cor e Forma:SolidPeso molecular:267.24PVZB1194
CAS:PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFórmula:C13H9F4NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.28(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Fórmula:C24H25Cl2F3N4OPureza:98%Cor e Forma:SolidPeso molecular:513.38(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Fórmula:C19H18F2N4O2SPureza:99.29%Cor e Forma:SolidPeso molecular:404.43Ref: TM-T13467
1mg37,00€5mg88,00€10mg120,00€25mg216,00€50mg354,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)87,00€CDK9 inhibitor HH1
CAS:CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.Fórmula:C13H15N3OSPureza:97.97%Cor e Forma:SolidPeso molecular:261.34RP-6306
CAS:Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.Fórmula:C18H20N4O2Pureza:98.41% - 99.28%Cor e Forma:SolidPeso molecular:324.38CDK2 degrader 3
CAS:CDK2 degrader3 selectively degrades CDK2 and exhibits antitumor activity.Fórmula:C44H53ClN10O6SCor e Forma:SolidPeso molecular:885.47Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Fórmula:C26H34N8OPureza:99%Cor e Forma:SolidPeso molecular:474.6360A
CAS:360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).Fórmula:C27H23N5O2Pureza:98.68%Cor e Forma:SolidPeso molecular:449.5Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Fórmula:C13H14Cl3N7O4Pureza:96.74%Cor e Forma:SolidPeso molecular:438.65Ref: TM-T8561
1mg48,00€2mg63,00€5mg87,00€10mg140,00€25mg274,00€50mg472,00€100mg710,00€1mL*10mM (DMSO)97,00€Rosnilimab
CAS:Rosnilimab is a humanized IgG1-κ antibody that targets PD-1 [1] [2].Pureza:98%Cor e Forma:LiquidEHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Fórmula:C25H30N6OPureza:100% - 99.86%Cor e Forma:SolidPeso molecular:430.55Ref: TM-T2427
5mg48,00€10mg73,00€25mg127,00€50mg213,00€100mg334,00€200mg492,00€500mg787,00€1mL*10mM (DMSO)52,00€YJ1206
CAS:YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader oral, DNA damage and cell-cycle arrest,and inhibits the proliferation of prostate cancer cells.Fórmula:C49H52FN11O5Pureza:97.14%Cor e Forma:SolidPeso molecular:894.01MBM-17S
CAS:MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest andFórmula:C36H40N6O10Pureza:98%Cor e Forma:SolidPeso molecular:716.74WRN inhibitor 2
CAS:WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Fórmula:C15H11F3N2O5S2Pureza:98%Cor e Forma:SolidPeso molecular:420.38DMT-dG(ib) Phosphoramidite
CAS:DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.Fórmula:C44H54N7O8PPureza:99.74%Cor e Forma:SolidPeso molecular:839.92SU-9516
CAS:SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.Fórmula:C13H11N3O2Pureza:99.59%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T8819
1mg90,00€5mg131,00€10mg170,00€25mg248,00€50mg321,00€100mg419,00€500mg938,00€1mL*10mM (DMSO)117,00€Aaptamine
CAS:Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.Fórmula:C13H12N2O2Pureza:98%Cor e Forma:SolidPeso molecular:228.25c-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFórmula:C20H22N6OPureza:98%Cor e Forma:SolidPeso molecular:362.43AI-10-49
CAS:AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.Fórmula:C30H22F6N6O5Pureza:97.14%Cor e Forma:SolidPeso molecular:660.52Ref: TM-T6753
2mg40,00€5mg60,00€10mg96,00€25mg169,00€50mg245,00€100mg361,00€200mg512,00€1mL*10mM (DMSO)88,00€SR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Fórmula:C16H20ClN3O4SPureza:99.78%Cor e Forma:SoildPeso molecular:385.87Ref: TM-T60037
5mg39,00€10mg64,00€25mg117,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)62,00€SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Fórmula:C31H34Cl2N2O3Pureza:95.58% - 99.70%Cor e Forma:SolidPeso molecular:553.52Ref: TM-T2255
1mg42,00€5mg106,00€10mg163,00€25mg278,00€50mg429,00€100mg657,00€500mg1.501,00€1mL*10mM (DMSO)130,00€13-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23DL-Alanosine
CAS:DL-Alanosine is an amino acid analog with antitumor activity.Fórmula:C3H7N3O4Cor e Forma:SolidPeso molecular:149.105Caracemide
CAS:Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.Fórmula:C6H11N3O4Pureza:98.81%Cor e Forma:SolidPeso molecular:189.17AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61PD-1-IN-17
CAS:PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Fórmula:C13H22N6O7Pureza:99.6%Cor e Forma:SolidPeso molecular:374.35PD-L1-IN-2
CAS:PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Fórmula:C33H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:586.68Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Fórmula:C6H14ClN3O5S2Cor e Forma:SolidPeso molecular:307.785-Fluorouridine 5'-phosphate
CAS:5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.Fórmula:C9H12FN2O9PCor e Forma:SolidPeso molecular:342.172AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Fórmula:C16H12N8OCor e Forma:SolidPeso molecular:332.32KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Cor e Forma:SolidPeso molecular:360.33Ref: TM-T9446
1mg96,00€2mg143,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)249,00€2-Keto-D-galactose
CAS:2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.Fórmula:C6H10O6Pureza:98%Cor e Forma:SolidPeso molecular:178.14Zn(BQTC)
CAS:Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.Fórmula:C30H36Cl2N5O3ZnPureza:98%Cor e Forma:SolidPeso molecular:650.92Ocifisertib(CFI-400945 free base)
CAS:Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase 4.Cost-effective and quality-assured.Fórmula:C33H34N4O3Pureza:97.56% - 98.53%Cor e Forma:SolidPeso molecular:534.65ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Cor e Forma:SolidPeso molecular:711.67Eciruciclib
CAS:Eciruciclib is an inhibitor of CDK with antitumor properties.Fórmula:C27H33FN8Pureza:97.51%Cor e Forma:SolidPeso molecular:488.6IBR2
CAS:IBR2 is a potent RAD51 inhibitor that disrupts DNA repair, inhibits cancer cell growth, and induces apoptosis.Fórmula:C24H20N2O2SPureza:96.15%Cor e Forma:SolidPeso molecular:400.49Ref: TM-T11600
1mg35,00€5mg70,00€10mg111,00€25mg183,00€50mg259,00€100mg359,00€200mg532,00€1mL*10mM (DMSO)77,00€Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Fórmula:C22H36N2O5SPureza:99.87%Cor e Forma:SolidPeso molecular:440.6Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Fórmula:C15H17FN4O3Pureza:98.68% - 99.89%Cor e Forma:Off-White To Yellow CrystalsPeso molecular:320.32
