Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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2'-O-(2-Azidoethyl)adenosine
CAS:2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.Fórmula:C12H16N8O4Pureza:95%Cor e Forma:SolidPeso molecular:336.31N-desmethyl Netupitant
CAS:N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Fórmula:C29H30F6N4OPureza:98%Cor e Forma:SolidPeso molecular:564.57PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Fórmula:C19H15F3N4O2Cor e Forma:SolidPeso molecular:388.34NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Fórmula:C13H17NO4SPureza:99.71%Cor e Forma:SolidPeso molecular:283.34WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:497.59Ref: TM-T8916
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Fórmula:C24H27N3O4SPureza:97.81%Cor e Forma:SolidPeso molecular:453.55Ref: TM-T21781
1mg35,00€2mg50,00€5mg74,00€10mg107,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)81,00€CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Fórmula:C20H21FN6O4SPureza:98%Cor e Forma:SolidPeso molecular:460.48CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Fórmula:C28H28N6O4Pureza:98.35% - 98.65%Cor e Forma:SolidPeso molecular:512.56Ref: TM-T4482
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg540,00€100mg775,00€500mg1.596,00€1mL*10mM (DMSO)127,00€Rhosin
CAS:Rhosin is a specific inhibitor of RhoA GTPases (Kd: ~0.4 uM), blocking RhoA-GEF interaction, not affecting Cdc42/Rac1/LARG, and induces apoptosis.Fórmula:C20H18N6OPureza:98%Cor e Forma:SolidPeso molecular:358.43MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Fórmula:C17H21N5Pureza:99.97%Cor e Forma:White SolidPeso molecular:295.38Ref: TM-T21678
5mg52,00€10mg96,00€25mg170,00€50mg269,00€100mg394,00€500mgA consultar1mL*10mM (DMSO)58,00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.81%Cor e Forma:Clear Colorless To Yellowish LiquidPeso molecular:114.53Trilaciclib
CAS:Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).Fórmula:C24H30N8OPureza:98%Cor e Forma:SolidPeso molecular:446.55NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.36%Cor e Forma:SolidPeso molecular:346.81Ref: TM-T2028
1mg74,00€2mg97,00€5mg158,00€10mg269,00€25mg515,00€50mg743,00€100mg1.035,00€500mg2.080,00€1mL*10mM (DMSO)158,00€5-Bromouridine
CAS:5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Fórmula:C9H11BrN2O6Pureza:99.89%Cor e Forma:White PowderPeso molecular:323.1CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Fórmula:C16H11N3OSPureza:97.24%Cor e Forma:SolidPeso molecular:293.34Ref: TM-T60619
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg273,00€100mg393,00€200mg550,00€1mL*10mM (DMSO)62,00€Fosifloxuridine nafalbenamide
CAS:Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.Fórmula:C29H29FN3O9PPureza:95.87%Cor e Forma:SolidPeso molecular:613.53Ref: TM-T33762
1mg88,00€5mg160,00€10mg216,00€25mg393,00€50mg550,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)210,00€Retifanlimab
CAS:Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Pureza:95% - 95%Cor e Forma:Liquid2'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Fórmula:C10H14N2O5SPureza:99.89%Cor e Forma:SolidPeso molecular:274.292'-O-Methylinosine
CAS:2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.Fórmula:C11H14N4O5Pureza:99.88%Cor e Forma:SolidPeso molecular:282.25B I09
CAS:B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Fórmula:C16H17NO5Pureza:99.23%Cor e Forma:SolidPeso molecular:303.31Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Fórmula:C93H134N22O25Pureza:99.92%Cor e Forma:SolidPeso molecular:1960.19ML-60218
CAS:ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Fórmula:C19H15Cl2N3O2S2Pureza:98.1%Cor e Forma:SolidPeso molecular:452.38Ref: TM-T40661
1mg56,00€5mg119,00€10mg187,00€25mg411,00€50mg638,00€100mg908,00€200mg1.225,00€1mL*10mM (DMSO)131,00€Filanesib
CAS:Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.Fórmula:C20H22F2N4O2SPureza:98.06%Cor e Forma:SolidPeso molecular:420.48Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Fórmula:C18H22BrN5O3Pureza:98.86% - 99.63%Cor e Forma:SolidPeso molecular:436.3BMS-1166
CAS:BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Fórmula:C36H33ClN2O7Pureza:99.22%Cor e Forma:SolidPeso molecular:641.11Ref: TM-T5697
1mg74,00€5mg155,00€10mg225,00€25mg429,00€50mg635,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)208,00€6-AZATHYMINE
CAS:6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Fórmula:C4H5N3O2Pureza:99.47%Cor e Forma:SolidPeso molecular:127.1CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg185,00€2mg279,00€5mg424,00€10mg627,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)470,00€Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein-coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFórmula:C51H74N14O13Pureza:98%Cor e Forma:SolidPeso molecular:1091.24Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Fórmula:C12H15N5O5Pureza:98.11%Cor e Forma:SolidPeso molecular:309.28Ref: TM-T9605
1mg126,00€5mg274,00€10mg416,00€25mg677,00€50mg944,00€100mg1.264,00€1mL*10mM (DMSO)360,00€Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Fórmula:C9H13N3O4SPureza:98%Cor e Forma:SolidPeso molecular:259.28CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formationFórmula:C45H48N6O8Pureza:98%Cor e Forma:SolidPeso molecular:800.95,6-Dihydro-5-methyluracil
CAS:5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.Fórmula:C5H8N2O2Pureza:98.53%Cor e Forma:SolidPeso molecular:128.13Dostarlimab
CAS:Dostarlimab (TSR-042) is an immune checkpoint inhibitor targeting PD-1, blocking its interaction with its ligands PD-L1 and PD-L2.Pureza:>95%Cor e Forma:LiquidGW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Fórmula:C20H11Cl2NO4Pureza:98.23%Cor e Forma:SolidPeso molecular:400.21Ref: TM-T9207L
1mg131,00€5mg286,00€10mg430,00€25mg647,00€50mg969,00€100mg1.301,00€1mL*10mM (DMSO)283,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 98.74%Cor e Forma:SolidPeso molecular:338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€RP-6685
CAS:RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Fórmula:C22H14F7N5OPureza:98.34%Cor e Forma:SoildPeso molecular:497.37Ref: TM-T60187
1mg88,00€5mg160,00€10mg230,00€25mg378,00€50mg538,00€100mg755,00€1mL*10mM (DMSO)170,00€dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Fórmula:C52H53Cl2FN8O12Pureza:99.44%Cor e Forma:SolidPeso molecular:1071.93CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Fórmula:C26H24ClFN4O4SCor e Forma:SolidPeso molecular:543.01Anticancer agent 73
CAS:Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Fórmula:C14H15NO4Pureza:99.19%Cor e Forma:SolidPeso molecular:261.27Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Fórmula:C43H51N3O11Pureza:98.05% - 99.40%Cor e Forma:Red-Orange Crystalline PowderPeso molecular:785.88Men 10376
CAS:Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.Fórmula:C57H68N12O10Pureza:98%Cor e Forma:SolidPeso molecular:1081.22Nivolumab
CAS:Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity. Cost-effective and quality-assured.Pureza:98% - 98%Cor e Forma:LiquidPeso molecular:146 kDa2',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS:2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication,AIDS and herpes.Fórmula:C21H40N2O6Si2Pureza:99.88%Cor e Forma:SolidPeso molecular:472.72Ref: TM-TNU1182
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Vitamin D2
CAS:Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.Fórmula:C28H44OPureza:98.73% - ≥98%Cor e Forma:Prisms From Acetone 1998)Peso molecular:396.65Aurora Kinases-IN-4
CAS:Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Fórmula:C26H28N8OPureza:98%Cor e Forma:SolidPeso molecular:468.55P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Fórmula:C53H81N13O11Pureza:99.61%Cor e Forma:SolidPeso molecular:1076.29Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Fórmula:C7H4O3S2Pureza:95.19%Cor e Forma:White To Off-White PowderPeso molecular:200.23Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。Fórmula:C27H32F2N8OPureza:98.32% - 99.29%Cor e Forma:SolidPeso molecular:522.59CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells.Fórmula:C35H56O10SPureza:98%Cor e Forma:SolidPeso molecular:668.88
