Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.35%Cor e Forma:SolidPeso molecular:408.88Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Fórmula:C26H21N3O3Pureza:97.45%Cor e Forma:SolidPeso molecular:423.46Ref: TM-T11155
1mg92,00€5mg205,00€10mg305,00€25mg495,00€50mg677,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)227,00€NU6102
CAS:NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Fórmula:C18H22N6O3SPureza:99.76%Cor e Forma:SolidPeso molecular:402.47CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Fórmula:C18H19ClFN3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:363.81Ref: TM-TQ0078
1mg40,00€2mg54,00€5mg92,00€10mg145,00€25mg271,00€50mg398,00€100mg562,00€500mg1.121,00€1mL*10mM (DMSO)97,00€PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results inFórmula:C17H13Br2N5OS·HBrPureza:98%Cor e Forma:SolidPeso molecular:576.1SHR5428
SHR5428 is an orally active, selective, noncovalent inhibitor of CDK7, displaying potent enzymatic inhibition (IC50 = 2.3 nM) and effectively suppressingPureza:98%Cor e Forma:Odour Solid5-Aminouridine
CAS:5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Fórmula:C9H13N3O6Pureza:100%Cor e Forma:SolidPeso molecular:259.22LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Fórmula:C53H59Cl2N3O7S2Cor e Forma:SolidPeso molecular:985.09Cytembena
CAS:Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Fórmula:C11H8BrNaO4Pureza:99.53%Cor e Forma:White PowderPeso molecular:307.07CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Fórmula:C23H28F2N8OPureza:99.85%Cor e Forma:SolidPeso molecular:470.52Ref: TM-T14990
1mg130,00€5mg311,00€10mg512,00€25mg1.074,00€50mg1.795,00€100mg2.375,00€1mL*10mM (DMSO)344,00€PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Cor e Forma:SolidPeso molecular:328.32AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Fórmula:C28H21N7OSPureza:98.35% - 98.9%Cor e Forma:SolidPeso molecular:503.58Ref: TM-T6380
1mg52,00€5mg97,00€10mg166,00€25mg303,00€50mg467,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)105,00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Fórmula:C27H28F3N5O2SPureza:98.85% - 99.5%Cor e Forma:SolidPeso molecular:543.6Ref: TM-T6282
1mg37,00€2mg52,00€5mg74,00€10mg124,00€25mg207,00€50mg374,00€100mg557,00€200mg797,00€500mg1.216,00€β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Fórmula:C15H12ClN3O2SCor e Forma:SolidPeso molecular:333.79Socazolimab
CAS:Socazolimab (ZKAB001) is a monoclonal antibody targeting PD-L1 with antitumor activity, used in studies of recurrent or metastatic cervical cancer.Pureza:95%Cor e Forma:LiquidPS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Cor e Forma:SolidPeso molecular:524.442'-Deoxy-2'-fluoroarabinoadenosine
CAS:2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.Fórmula:C10H12FN5O3Pureza:99.44%Cor e Forma:SolidPeso molecular:269.23PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Fórmula:C22H25ClN2O4Cor e Forma:SolidPeso molecular:416.90Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Fórmula:C24H32Cl2N8OPureza:98.61% - 99.69%Cor e Forma:SolidPeso molecular:519.47Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Cor e Forma:SolidPeso molecular:397.52Ref: TM-TQ0053
1mg48,00€5mg101,00€10mg178,00€25mg304,00€50mg437,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)111,00€KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Fórmula:C28H38N4O5S2Pureza:98.45%Cor e Forma:SolidPeso molecular:574.76Ro5-3335
CAS:Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Fórmula:C13H10ClN3OPureza:99.42% - 99.50%Cor e Forma:SolidPeso molecular:259.69(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Fórmula:C20H27F2N5O4SPureza:98.55%Cor e Forma:SolidPeso molecular:471.52Orotic acid zinc
CAS:Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.Fórmula:C10H6N4O8ZnPureza:99.13%Cor e Forma:SolidPeso molecular:188.79VVD-214
CAS:VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Fórmula:C20H21F2N3O4SPureza:99.24%Cor e Forma:SoildPeso molecular:437.46N-Nitrosonornicotine
CAS:N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Fórmula:C9H11N3OCor e Forma:SolidPeso molecular:177.2ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Fórmula:C28H24Cl2FN5O2Pureza:98.38%Cor e Forma:SolidPeso molecular:552.43Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Fórmula:C29H24Cl2N2O7SPureza:99.39% - 99.66%Cor e Forma:SolidPeso molecular:615.48Cdc7-IN-7c
CAS:Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Fórmula:C15H17N5OSPureza:99.31% - 99.77%Cor e Forma:SolidPeso molecular:315.39Ref: TM-T23867
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)633,00€CDK12-IN-2
CAS:CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.Fórmula:C32H32N6O2Pureza:99.54%Cor e Forma:SolidPeso molecular:532.64Ref: TM-T39752
1mg92,00€5mg216,00€10mg376,00€25mg620,00€50mg889,00€100mg1.198,00€1mL*10mM (DMSO)255,00€Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Fórmula:C29H42F3N9O9Pureza:98.99% - 99.54%Cor e Forma:SolidPeso molecular:717.69TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Fórmula:C24H26N2O3SPureza:98.23%Cor e Forma:SolidPeso molecular:422.54Peresolimab
CAS:Peresolimab, a humanized IgG1-κ antibody, targets PD-1 and may activate physiological immune inhibitory pathways, thereby restoring immune homeostasis [1] [2].Pureza:98%Cor e Forma:Liquid10-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Fórmula:C22H21N5O7Pureza:96.04%Cor e Forma:SolidPeso molecular:467.43CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Fórmula:C26H32BrN5O6Pureza:98.05% - 98.5%Cor e Forma:SolidPeso molecular:590.47Ref: TM-TQ0250
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg221,00€50mg369,00€100mg550,00€1mL*10mM (DMSO)96,00€2',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS:2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepilepticFórmula:C9H10F2N2O5Pureza:99.94%Cor e Forma:SolidPeso molecular:264.18FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Fórmula:C17H18FN3SPureza:98.61%Cor e Forma:SolidPeso molecular:315.41KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral bloodFórmula:C24H24ClFN2O3Pureza:98%Cor e Forma:SolidPeso molecular:442.915'-O-DMT-N2-ibu-dG
CAS:5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.Fórmula:C35H37N5O7Pureza:98.71%Cor e Forma:SolidPeso molecular:639.7Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.Fórmula:C16H10N2O2Pureza:97.52% - ≥95%Cor e Forma:SolidPeso molecular:262.26Tislelizumab
CAS:Tislelizumab, a PD-1 receptor monoclonal antibody, reduces Fcγ interaction and T cell clearance in advanced squamous NSCLC research.Pureza:95%Cor e Forma:LiquidDebio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Fórmula:C26H28Cl2N6OPureza:99.52%Cor e Forma:SolidPeso molecular:511.45Ref: TM-T9864
1mg95,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)255,00€BCH001
CAS:BCH001 is a specific small-molecule inhibitor of PAPD5.Fórmula:C20H15F3N2O5Pureza:99.06%Cor e Forma:SolidPeso molecular:420.34Human membrane-bound PD-L1 polypeptide
CAS:Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Fórmula:C85H140N26O36SPureza:98%Cor e Forma:SolidPeso molecular:2134.24GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Fórmula:C30H33N7OPureza:99.73%Cor e Forma:SolidPeso molecular:507.63Adenine hydrochloride
CAS:Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.Fórmula:C5H5N5·HClPureza:98.86%Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:171.59RS-1
CAS:RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.Fórmula:C20H16Br2N2O3SPureza:99.72%Cor e Forma:SolidPeso molecular:524.23Ref: TM-T6972
5mg51,00€10mg79,00€25mg126,00€50mg210,00€100mg354,00€200mg517,00€500mg825,00€1mL*10mM (DMSO)59,00€TREX1-IN-4
CAS:TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Fórmula:C30H32ClN7OSPureza:98%Cor e Forma:SolidPeso molecular:574.14
