Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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Anti-Mouse PD-1 Antibody (RMP1-14)
RMP1-14 is an IgG1-like immunoglobulin and anti-Mouse PD-1 antibody that blocks PD-1/PD-L1 signaling.Pureza:14.68mg/ml - >95%Cor e Forma:Odour LiquidTREX1-IN-3
CAS:TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPureza:98%Cor e Forma:Liquid2',3'-Isopropylideneuridine
CAS:2',3'-Isopropylideneuridine is a nucleoside derivative that has shown antiviral activity in several studies, particularly against Flaviviruses, such as HCV.Fórmula:C12H16N2O6Pureza:99.91%Cor e Forma:SolidPeso molecular:284.27N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
CAS:N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenine nucleoside analog with potential vasodilator activity and anticancer activity.Fórmula:C47H52N7O7PPureza:98.59%Cor e Forma:SolidPeso molecular:857.93Ref: TM-TNU1119
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€500mg3.734,00€DMT-2′Fluoro-dU Phosphoramidite
CAS:DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) can be used to modify nucleosides.Fórmula:C39H46FN4O8PPureza:98.45%Cor e Forma:SolidPeso molecular:748.78Azelaoyl PAF
CAS:Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Fórmula:C33H66NO9PCor e Forma:SolidPeso molecular:651.85Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Fórmula:C23H18ClF2N7O3SCor e Forma:SolidPeso molecular:545.95CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFórmula:C18H20N6OSPureza:96.6% - 97.59%Cor e Forma:SolidPeso molecular:368.46Ref: TM-T6458
2mg39,00€5mg56,00€10mg78,00€25mg135,00€50mg217,00€100mg358,00€500mg908,00€1mL*10mM (DMSO)49,00€BAY1217389
CAS:BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).Fórmula:C27H24F5N5O3Pureza:95.71% - 98.78%Cor e Forma:SolidPeso molecular:561.5Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Fórmula:C16H11N3Pureza:99.69%Cor e Forma:SolidPeso molecular:245.28Ref: TM-T12359
5mg48,00€10mg62,00€25mg97,00€50mg169,00€100mg250,00€200mg373,00€500mg612,00€1mL*10mM (DMSO)52,00€CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂,IC50分别为 2.7 和 16 nM。Fórmula:C27H32F2N8Pureza:99.47%Cor e Forma:SolidPeso molecular:506.59Cytidine
CAS:Cytidine (Cytosine-1-β-D-ribofuranoside) is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond.Fórmula:C9H13N3O5Pureza:98.80% - 99.63%Cor e Forma:Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:243.22T2AA
CAS:T2AA (4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol) is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-Fórmula:C15H15I2NO3Pureza:98.19%Cor e Forma:SolidPeso molecular:511.09QR-6401
CAS:QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/Fórmula:C19H23N5O3Pureza:98%Cor e Forma:SolidPeso molecular:369.42N,N-Dimethyl-2'-O-methylcytidine
CAS:N,N-Dimethyl-2'-O-methylcytidine (N4, N4, 2'-O-Trimethylcytidine) is a purine nucleoside analogue with anti-cancer activity.Fórmula:C12H19N3O5Pureza:99.62%Cor e Forma:SolidPeso molecular:285.32'-O-Methyl-5-iodouridine
CAS:2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses aFórmula:C10H13IN2O6Pureza:98.32%Cor e Forma:SolidPeso molecular:384.12Deoxycytidine triphosphate
CAS:dCTP is a nucleotide used in DNA synthesis, PCR, cDNA creation, and sequencing.Fórmula:C9H16N3O13P3Pureza:95.19%Cor e Forma:SolidPeso molecular:467.16Kif15-IN-1
CAS:Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Fórmula:C20H22N4O5SPureza:99.39% - 99.39%Cor e Forma:SolidPeso molecular:430.48TC-Mps1-12
CAS:TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .Fórmula:C17H20N6OPureza:98%Cor e Forma:SolidPeso molecular:324.38N2-Methylguanosine
CAS:N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA'sFórmula:C11H15N5O5Pureza:97.77%Cor e Forma:SolidPeso molecular:297.27PNU112455A hydrochloride
CAS:PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Fórmula:C10H12ClN5O2SPureza:98.58% - 99.22%Cor e Forma:SolidPeso molecular:301.75Ref: TM-T8230
2mg47,00€5mg74,00€10mg105,00€25mg182,00€50mg281,00€100mg459,00€500mg1.017,00€1mL*10mM (DMSO)84,00€L82-G17
CAS:L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.Fórmula:C11H9ClN4O2Pureza:99.78%Cor e Forma:SolidPeso molecular:264.67αVβ8-IN-1
CAS:αVβ8-IN-1 is an inhibitor of the αVβ8 integrin. It exhibits growth-suppressive activity against tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 is suitable for research related to idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and various cancers.Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.01Pritelivir
CAS:Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).Fórmula:C18H18N4O3S2Pureza:97.96% - 99.42%Cor e Forma:SolidPeso molecular:402.49Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidTipiracil hydrochloride
CAS:Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).Fórmula:C9H12Cl2N4O2Pureza:100% - ≥95%Cor e Forma:SolidPeso molecular:279.12Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Cor e Forma:SolidPeso molecular:862.91αvβ1 integrin-IN-1
CAS:αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Fórmula:C26H34N6O6SPureza:100% - 99.74%Cor e Forma:SolidPeso molecular:558.65Ref: TM-T13473
1mg115,00€5mg274,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€200mg1.738,00€1mL*10mM (DMSO)349,00€DHX9-IN-4
CAS:DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Fórmula:C21H22ClN5O4S2Pureza:98.12%Cor e Forma:SolidPeso molecular:508.01PDL-1 cpd 10
CAS:PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.Fórmula:C21H23N5O2Pureza:97.08%Cor e Forma:SolidPeso molecular:377.44Ref: TM-T9359
1mg55,00€5mg117,00€10mg187,00€25mg393,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)134,00€K34c hydrochloride
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Fórmula:C38H50ClN5O2Pureza:100% - 99.95%Cor e Forma:SoildPeso molecular:644.29Ref: TM-T41151L
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)887,00€LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFórmula:C27H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:505.59SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Cor e Forma:SolidPeso molecular:376.25Ref: TM-T2517
1mg52,00€2mg78,00€5mg115,00€10mg168,00€25mg283,00€50mg462,00€100mg660,00€1mL*10mM (DMSO)124,00€Lifitegrast sodium
CAS:Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.Fórmula:C29H23Cl2N2NaO7SPureza:99.33%Cor e Forma:SolidPeso molecular:637.46Pembrolizumab
CAS:Pembrolizumab (MK-3475) is a humanized monoclonal antibody.Cost-effective and quality-assured.Pureza:95% - 99.70%Cor e Forma:LiquidPeso molecular:149 kDaART812
CAS:ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM.Fórmula:C19H16ClF4N3O4Pureza:99.32%Cor e Forma:SolidPeso molecular:461.79Ref: TM-T40236
1mg116,00€5mg283,00€10mg452,00€25mg747,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)280,00€XU1
CAS:XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation orFórmula:C12H8N2OPureza:100% - 98.97%Cor e Forma:SolidPeso molecular:196.2Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:97.29%Cor e Forma:SolidPeso molecular:387.43Ref: TM-T10464L
1mg88,00€2mg120,00€5mg202,00€10mg329,00€25mg612,00€50mg817,00€100mg1.121,00€1mL*10mM (DMSO)224,00€CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Fórmula:C22H25F3N6Pureza:98%Cor e Forma:SolidPeso molecular:430.47CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Cor e Forma:SolidPeso molecular:486.38Ref: TM-T8930
2mg35,00€5mg52,00€10mg89,00€25mg167,00€50mg258,00€100mg379,00€200mg540,00€1mL*10mM (DMSO)58,00€Cidofovir
CAS:Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。Fórmula:C8H14N3O6PPureza:99.24% - 99.76%Cor e Forma:Fluffy White PowderPeso molecular:279.19Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Fórmula:C22H16FN3O2SCor e Forma:SolidPeso molecular:405.445Cytarabine hydrochloride
CAS:Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.Fórmula:C9H14ClN3O5Pureza:99.62%Cor e Forma:White PowderPeso molecular:279.68Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27N6-Methyl-2'-O-methyladenosine
CAS:N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound foundFórmula:C12H17N5O4Pureza:99.77%Cor e Forma:SolidPeso molecular:295.29Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.12%Cor e Forma:SolidPeso molecular:512.46ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Fórmula:C19H18N4O4Pureza:99.48%Cor e Forma:SolidPeso molecular:366.37Ap4dT
CAS:Ap4dT serves as an inhibitor of human adenylate kinase isozyme 1 (hAK1), effectively suppressing the synthesis of ATP and ADP, with IC50 values of 42 μM and 38 μM, respectively.Fórmula:C20H41N11O20P4Cor e Forma:SolidPeso molecular:879.5α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Fórmula:C23H29N3O6SPureza:98%Cor e Forma:SolidPeso molecular:475.56
