Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
Exibir 11 mais subcategorias
Produtos da "Ciclo celular/Ponto de verificação"
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CDK9-IN-9
CAS:CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Fórmula:C22H23F2N5O2SPureza:98%Cor e Forma:SolidPeso molecular:459.51GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Fórmula:C32H38ClN5O4Pureza:96.22% - 98.02%Cor e Forma:SolidPeso molecular:592.13Ref: TM-T2039
1mg49,00€2mg70,00€5mg97,00€10mg168,00€25mg331,00€50mg510,00€100mg737,00€1mL*10mM (DMSO)136,00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Fórmula:C18H19NO3Pureza:99.19%Cor e Forma:SolidPeso molecular:297.35GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Fórmula:C29H37N5O2xHClPureza:99.54%Cor e Forma:SolidPeso molecular:0LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Fórmula:C10H12N4O4SPureza:98%Cor e Forma:SolidPeso molecular:284.29(R)-Enitociclib
CAS:(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Fórmula:C19H18F2N4O2SPureza:98.82%Cor e Forma:SoildPeso molecular:404.43CX-5461
CAS:CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Fórmula:C27H27N7O2SPureza:95.44% - 99.25%Cor e Forma:SolidPeso molecular:513.61IRE1α kinase-IN-1
CAS:IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.Fórmula:C26H26ClFN8Pureza:99.18%Cor e Forma:SolidPeso molecular:504.99Ref: TM-T9564
1mg116,00€5mg283,00€10mg452,00€25mg707,00€50mg1.017,00€100mg1.406,00€1mL*10mM (DMSO)311,00€CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Fórmula:C9H6N2O4Pureza:98.27% - 98.98%Cor e Forma:Brown PowderPeso molecular:206.15INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Fórmula:C41H39N7O4Pureza:98.21%Cor e Forma:SolidPeso molecular:693.79Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Fórmula:C21H16ClN3O4Cor e Forma:SolidPeso molecular:409.82BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Fórmula:C11H16BrN2O14P3Pureza:98%Cor e Forma:SolidPeso molecular:573.08Tirofiban hydrochloride monohydrate
CAS:Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Fórmula:C22H39ClN2O6SPureza:95.83% - 99.94%Cor e Forma:White SolidPeso molecular:495.07S-Gem
CAS:S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.Fórmula:C13H15F2N3O6S2Pureza:98%Cor e Forma:SolidPeso molecular:411.4CBFβ Inhibitor
CAS:CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Fórmula:C12H14N2OSPureza:96.50%Cor e Forma:SolidPeso molecular:234.32Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFórmula:C21H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:378.49Poly(A) polymerase
CAS:Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.Pureza:98%Cor e Forma:Solid5-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Fórmula:C5H3FN2O4Pureza:100% - 99.7%Cor e Forma:White To Pale Yellow PowderPeso molecular:174.09MU147
CAS:MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Fórmula:C19H13N3O3SCor e Forma:SolidPeso molecular:363.39Deoxythymidine triphosphate
CAS:Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Fórmula:C10H14N2Na3O14P3Pureza:96.00%Cor e Forma:White Amorphous PowderPeso molecular:548.11PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Fórmula:C14H15NO2S2Pureza:98.20% - 99.98%Cor e Forma:SolidPeso molecular:293.4TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Fórmula:C21H17N3O3Pureza:99.68%Cor e Forma:SolidPeso molecular:359.38Ref: TM-T17008
1mg57,00€2mg84,00€5mg125,00€10mg188,00€25mg354,00€50mg532,00€100mg712,00€500mgA consultar1mL*10mM (DMSO)138,00€Metarrestin
CAS:Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Fórmula:C31H30N4OPureza:99.45%Cor e Forma:SolidPeso molecular:474.6Ref: TM-T12006
1mg40,00€2mg52,00€5mg88,00€10mg144,00€25mg298,00€50mg512,00€100mg740,00€500mg1.539,00€RG7800 tetrahydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.Fórmula:C24H32Cl4N6OPureza:98%Cor e Forma:SolidPeso molecular:562.362'-Deoxy-N4-methylcytidine
CAS:2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Fórmula:C10H15N3O4Pureza:99.61%Cor e Forma:SolidPeso molecular:241.24HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Cor e Forma:SolidPeso molecular:382.43Ref: TM-T3643
1mg43,00€2mg56,00€5mg88,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)79,00€SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Fórmula:C19H15F3N6O2Cor e Forma:SolidPeso molecular:416.36APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Fórmula:C17H16N8Pureza:96.51% - 98.46%Cor e Forma:SolidPeso molecular:332.36Ref: TM-T3654
2mg43,00€5mg65,00€10mg96,00€25mg177,00€50mg301,00€100mg543,00€500mg1.130,00€1mL*10mM (DMSO)71,00€Budigalimab
CAS:Budigalimab (ABBV 181) is a humanized monoclonal antibody targeting PD-1 with potential antitumor activity.Pureza:95% - 95%Cor e Forma:LiquidHomouridine
CAS:Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Fórmula:C10H14N2O6Pureza:98%Cor e Forma:SolidPeso molecular:258.23CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Fórmula:C22H26N4OPureza:98.21%Cor e Forma:SolidPeso molecular:362.47Avelumab
CAS:Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.Pureza:95% - 98.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.8 kDaDatelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Fórmula:C23H28ClN3OPureza:98%Cor e Forma:SolidPeso molecular:397.94CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:98.07%Cor e Forma:SolidPeso molecular:328.35Ref: TM-T9615
1mg52,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)139,00€Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.63%Cor e Forma:SolidPeso molecular:587.54Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Fórmula:C17H19N5OSPureza:99.82% - 99.93%Cor e Forma:SolidPeso molecular:341.43Ref: TM-T12642L
1mg74,00€2mg96,00€5mg180,00€10mg250,00€25mg465,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)187,00€Acrixolimab
CAS:Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].Pureza:98%Cor e Forma:Liquid6-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Fórmula:C10H12N4O4SPureza:97.74%Cor e Forma:SolidPeso molecular:284.29Ref: TM-T7621
2mg51,00€5mg85,00€10mg119,00€25mg150,00€50mg188,00€100mg283,00€200mg432,00€1mL*10mM (DMSO)99,00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:98.00%Cor e Forma:LiquidPeso molecular:N/AKJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Fórmula:C22H15N3O4Pureza:98.07% - ≥98%Cor e Forma:SolidPeso molecular:385.37Ref: TM-T15665
2mg39,00€5mg57,00€10mg81,00€25mg145,00€50mg279,00€100mg510,00€200mg683,00€500mg1.064,00€1mL*10mM (DMSO)63,00€DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.Fórmula:C26H18ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:439.89IXA6
CAS:IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Fórmula:C22H20ClN3O3SPureza:98.63%Cor e Forma:SolidPeso molecular:441.93CW-069
CAS:CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Fórmula:C23H21IN2O3Pureza:97.52% - 98.59%Cor e Forma:SolidPeso molecular:500.33Ref: TM-T6209
1mg43,00€5mg90,00€10mg125,00€25mg216,00€50mg306,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)89,00€DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Fórmula:C19H14BrN5OPureza:98%Cor e Forma:SolidPeso molecular:408.25Cdc7-IN-7
CAS:Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.Fórmula:C21H22N4O5Pureza:99.25%Cor e Forma:SolidPeso molecular:410.42ZIM
CAS:ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Fórmula:C20H19N3O3Pureza:99.13%Cor e Forma:SolidPeso molecular:349.38Ref: TM-T72024
5mg39,00€10mg58,00€25mg105,00€50mg170,00€100mg271,00€200mg398,00€1mL*10mM (DMSO)52,00€Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:97.81%Cor e Forma:SolidPeso molecular:451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Fórmula:C27H26N6OPureza:99.67%Cor e Forma:SolidPeso molecular:450.53Ref: TM-T8430
1mg97,00€2mg131,00€5mg188,00€10mg305,00€25mg487,00€50mg655,00€100mg905,00€1mL*10mM (DMSO)215,00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Cor e Forma:SolidPeso molecular:378.27CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Fórmula:C21H23ClN6OPureza:97.74%Cor e Forma:SolidPeso molecular:410.9Ref: TM-T14901
1mg95,00€5mg221,00€10mg324,00€25mg548,00€50mg785,00€100mg1.074,00€1mL*10mM (DMSO)202,00€
