Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].Fórmula:C30H36N4O6S2Pureza:98%Cor e Forma:SolidPeso molecular:612.76BMS-1001 hydrochloride
CAS:BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effectFórmula:C35H35ClN2O7Pureza:97.36%Cor e Forma:SolidPeso molecular:631.11Ref: TM-T10565
1mg56,00€5mg127,00€10mg197,00€25mg401,00€50mg645,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)172,00€ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Cor e Forma:SolidPeso molecular:584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€CID 5951923
CAS:CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.Fórmula:C16H18N2O7SPureza:100.00%Cor e Forma:SolidPeso molecular:382.39Barasertib-HQPA
CAS:Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Cor e Forma:SolidPeso molecular:507.56TH588
CAS:TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.Fórmula:C13H12Cl2N4Pureza:96.05% - 99.82%Cor e Forma:SolidPeso molecular:295.17AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.79%Cor e Forma:SolidPeso molecular:442.32Ref: TM-T10215
1mg95,00€5mg202,00€10mg303,00€25mg550,00€50mg825,00€100mg1.198,00€1mL*10mM (DMSO)233,00€Palbociclib monohydrochloride
CAS:Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinasesFórmula:C24H29N7O2·HClPureza:100% - 99.91%Cor e Forma:SolidPeso molecular:483.99JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:100% - 99.96%Cor e Forma:SolidPeso molecular:505.08LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.17%Cor e Forma:SolidPeso molecular:453.34Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Cor e Forma:SolidPeso molecular:588.66Ref: TM-T2494
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg274,00€50mg439,00€100mg632,00€1mL*10mM (DMSO)137,00€Mirvetuximab
CAS:Mirvetuximab, a monoclonal antibody targeting FOLR1/FRα, treats ovarian and FRα-positive cancers, often paired with platinum-based drugs.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:148 kDa (average)Ispinesib
CAS:Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFórmula:C30H33ClN4O2Pureza:98% - 98.59%Cor e Forma:SolidPeso molecular:517.06Ref: TM-T2103
1mg39,00€2mg50,00€5mg79,00€10mg118,00€25mg210,00€50mg339,00€100mg557,00€500mg1.216,00€1mL*10mM (DMSO)89,00€CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Fórmula:C19H18N4O4S2Pureza:98%Cor e Forma:SolidPeso molecular:430.5Werner syndrome RecQ helicase-IN-1
CAS:Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomachFórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Cor e Forma:SolidPeso molecular:702.08Ref: TM-T72107
1mg60,00€5mg125,00€10mg177,00€25mg296,00€50mg502,00€100mg803,00€500mg1.795,00€1mL*10mM (DMSO)822,00€CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53Folinic Acid Calcium Salt Pentahydrate
CAS:Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.Fórmula:C20H21CaN7O7·5H2OPureza:100% - 99.17%Cor e Forma:Yellowish-White To Yellow PowderPeso molecular:601.58NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Fórmula:C23H19N3O4SPureza:98.03% - 99.46%Cor e Forma:SolidPeso molecular:433.48Ref: TM-T8886
1mg74,00€5mg170,00€10mg274,00€25mg472,00€50mg655,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)188,00€GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Fórmula:C27H32N6OPureza:99.57%Cor e Forma:SolidPeso molecular:456.58N6,N6-Dimethyladenosine
CAS:N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.Fórmula:C12H17N5O4Pureza:98.79%Cor e Forma:White PowderPeso molecular:295.29Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Fórmula:C21H18F3N5OPureza:98.91%Cor e Forma:SolidPeso molecular:413.4Ref: TM-T5524
1mg78,00€2mg97,00€5mg188,00€10mg298,00€25mg500,00€50mg710,00€100mg938,00€200mg1.311,00€1mL*10mM (DMSO)215,00€HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Fórmula:C24H27FN4O5Cor e Forma:SolidPeso molecular:470.49RG7800
CAS:RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.Fórmula:C24H28N6OPureza:99.44%Cor e Forma:SolidPeso molecular:416.52ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Fórmula:C21H21F3N4O2Pureza:99.18%Cor e Forma:SolidPeso molecular:418.41PD-1/PD-L1-IN-NP19
CAS:PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Fórmula:C33H31ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:555.06Doxifluridine
CAS:Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.Fórmula:C9H11FN2O5Pureza:99.47% - 99.86%Cor e Forma:White SolidPeso molecular:246.192′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Fórmula:C10H12FN5O4Pureza:99.82%Cor e Forma:SolidPeso molecular:285.23Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Fórmula:C21H22N4O6SPureza:98.99% - 99.06%Cor e Forma:Yellow Crystalline PowderPeso molecular:458.49SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Fórmula:C20H26N8OSPureza:98%Cor e Forma:SolidPeso molecular:426.54Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.10% - 99.33%Cor e Forma:SolidPeso molecular:558.7AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potentFórmula:C23H28FN7OPureza:98.01%Cor e Forma:SolidPeso molecular:437.51Ref: TM-T21544
1mg57,00€5mg120,00€10mg187,00€25mg416,00€50mg655,00€100mg924,00€1mL*10mM (DMSO)144,00€Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Fórmula:C26H42N4O5Pureza:98.82%Cor e Forma:SolidPeso molecular:490.64T4 RNA ligase
T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA.Pureza:98%Cor e Forma:Odour SolidMonastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Fórmula:C14H16N2O3SPureza:98.59% - 99.19%Cor e Forma:SolidPeso molecular:292.35Ref: TM-T4048
1mg48,00€5mg78,00€10mg97,00€25mg188,00€50mg311,00€100mg502,00€500mg1.074,00€1mL*10mM (DMSO)87,00€Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.Fórmula:C19H22FN3O3Pureza:100% - 99.89%Cor e Forma:Pale Yellow CrystalsPeso molecular:359.39PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Fórmula:C20H27F2N5O4SPureza:98.77% - 99.58%Cor e Forma:SolidPeso molecular:471.52Ref: TM-T8463
1mg57,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)131,00€Zimberelimab
CAS:Zimberelimab (GLS-010) is a humanized antibody targeting PD-1, with anticancer activity.Pureza:95%Cor e Forma:Liquid7-Methylguanosine
CAS:7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Fórmula:C11H16N5O5Pureza:98.11%Cor e Forma:SolidPeso molecular:298.282′-O-Methylcytidine
CAS:2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.Fórmula:C10H15N3O5Pureza:99.81%Cor e Forma:SolidPeso molecular:257.24Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Fórmula:C25H22ClFN6O2SPureza:98.34%Cor e Forma:SolidPeso molecular:525TK216
CAS:TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Fórmula:C19H15Cl2NO3Pureza:97.22%Cor e Forma:SolidPeso molecular:376.23(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Fórmula:C14H16N2O3SPureza:98%Cor e Forma:SolidPeso molecular:292.356-Mercaptopurine
CAS:6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Fórmula:C5H4N4SPureza:99.53% - 99.63%Cor e Forma:Yellow Crystalline Powder SolidPeso molecular:152.18KIF18A-IN-15
CAS:KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Fórmula:C25H33F3N6O5SCor e Forma:SolidPeso molecular:586.63Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Fórmula:C22H20Cl2F3NO5Pureza:98%Cor e Forma:SolidPeso molecular:506.33-Methylcytidine
CAS:3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.Fórmula:C10H15N3O5Pureza:98%Cor e Forma:SolidPeso molecular:257.24Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Fórmula:C20H20N6O4SPureza:98.17%Cor e Forma:SolidPeso molecular:440.48CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Fórmula:C17H11ClN2OPureza:98.41%Cor e Forma:SoildPeso molecular:294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Cor e Forma:SolidPeso molecular:422.52Ref: TM-T16359
2mg42,00€5mg64,00€10mg97,00€25mg187,00€50mg301,00€100mg437,00€200mg612,00€1mL*10mM (DMSO)71,00€Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Fórmula:C26H25ClN4O2Pureza:98.5%Cor e Forma:SolidPeso molecular:460.96
