Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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Dithranol
CAS:Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especiallyFórmula:C14H10O3Pureza:93.49% - ≥98%Cor e Forma:Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingPeso molecular:226.23Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Fórmula:C26H25F2N7O6S2Pureza:98.76%Cor e Forma:SolidPeso molecular:633.65Zeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Fórmula:C18H20F3N4O2PCor e Forma:SolidPeso molecular:412.346CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Fórmula:C20H18N4OCor e Forma:SolidPeso molecular:330.38EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Fórmula:C25H24N2O4Pureza:98.51%Cor e Forma:SolidPeso molecular:416.47TAME
CAS:Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.Fórmula:C14H22N4O4SPureza:98%Cor e Forma:SolidPeso molecular:342.41Amenamevir
CAS:Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFórmula:C24H26N4O5SPureza:99.00% - 99.86%Cor e Forma:SolidPeso molecular:482.55Ref: TM-T4226
1mg60,00€2mg79,00€5mg124,00€10mg197,00€25mg325,00€50mg505,00€100mg730,00€500mg1.501,00€1mL*10mM (DMSO)140,00€Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Fórmula:C21H22ClNO4Pureza:97.9% - 99.47%Cor e Forma:SolidPeso molecular:387.857Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Cor e Forma:SolidPeso molecular:385.85Ref: TM-T4321
1mg35,00€2mg46,00€5mg66,00€10mg93,00€25mg137,00€50mg210,00€100mg314,00€1mL*10mM (DMSO)72,00€TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Fórmula:C24H21Cl2NO5Pureza:98.98%Cor e Forma:SolidPeso molecular:474.33Ref: TM-T5310
1mg52,00€5mg105,00€10mg170,00€25mg298,00€50mg430,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)111,00€Tegafur
CAS:Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity.Fórmula:C8H9FN2O3Pureza:99.16% - 99.89%Cor e Forma:White Crystalline PowderPeso molecular:200.17BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Fórmula:C22H21FN6O5Cor e Forma:SolidPeso molecular:468.44Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Fórmula:C24H17ClF2N6O4Pureza:97.87% - 99.51%Cor e Forma:SolidPeso molecular:526.88Ref: TM-T4367
1mg49,00€5mg99,00€10mg168,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)116,00€TASIN-30
CAS:TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Fórmula:C18H30N2O3SCor e Forma:SolidPeso molecular:354.51ITX3
CAS:ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Fórmula:C22H17N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:371.45GSK_WRN4
CAS:GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFórmula:C16H20N2O4SPureza:100%Cor e Forma:SolidPeso molecular:336.41Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:≥95%Cor e Forma:SolidPeso molecular:847.72Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Fórmula:C23H16ClFN4OPureza:98.21%Cor e Forma:SolidPeso molecular:418.85ASC-69
CAS:ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Fórmula:C19H19N7Pureza:98%Cor e Forma:SolidPeso molecular:345.4T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Fórmula:C19H14F3N3O3Pureza:98.39% - 98.61%Cor e Forma:SolidPeso molecular:389.33IMT1B
CAS:IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Fórmula:C24H21ClFNO6Pureza:98.26% - 99.64%Cor e Forma:SolidPeso molecular:473.88Ref: TM-T8842
1mg145,00€5mg311,00€10mg533,00€25mg775,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)325,00€CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Fórmula:C18H18N4O2Pureza:97.07%Cor e Forma:SolidPeso molecular:322.36SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Fórmula:C25H20FN7OPureza:99.52%Cor e Forma:SolidPeso molecular:453.47Ref: TM-T41256
1mg73,00€5mg160,00€10mg250,00€25mg445,00€50mg625,00€100mg909,00€200mg1.216,00€1mL*10mM (DMSO)170,00€Valacyclovir hydrochloride
CAS:Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.Fórmula:C13H20N6O4·HClPureza:100% - ≥95%Cor e Forma:White To Off-White Crystalline PowerPeso molecular:360.8Ref: TM-T1087
1g299,00€10mg47,00€25mg69,00€50mg85,00€100mg97,00€200mg127,00€500mg202,00€1mL*10mM (DMSO)47,00€Netivudine
CAS:Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.Fórmula:C12H14N2O6Pureza:99.83%Cor e Forma:SolidPeso molecular:282.25GW779439X
CAS:GW779439X is an inhibitor of CDK.Fórmula:C22H21F3N8Pureza:97.87%Cor e Forma:SolidPeso molecular:454.45Ref: TM-T8866
1mg62,00€2mg87,00€5mg119,00€10mg188,00€25mg425,00€50mg625,00€100mg892,00€1mL*10mM (DMSO)131,00€Rinatabart
Rinatabart is a humanized IgG1κ antibody that targets FOLR1. The corresponding isotype control is HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidTHZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:566.05RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Cor e Forma:SolidPeso molecular:410.41Ref: TM-T12783
1mg127,00€5mg311,00€10mg472,00€25mg747,00€50mg1.017,00€100mg1.311,00€200mg1.786,00€1mL*10mM (DMSO)344,00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Pureza:95% - 95%Cor e Forma:LiquidBMS202 hydrochloride (1675203-84-5(free base))
CAS:BMS202 hydrochloride (1675203-84-5) is a potent PD-1/PD-L1 inhibitor (IC50: 18 nM) that promotes PD-L1 dimerization, blocking PD1 binding.Fórmula:C25H30ClN3O3Pureza:99.47%Cor e Forma:SolidPeso molecular:455.97Ref: TM-T4696
1mg51,00€2mg63,00€5mg100,00€10mg160,00€25mg306,00€50mg548,00€100mg785,00€1mL*10mM (DMSO)100,00€CDK9/PARP-IN-1
CAS:CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Fórmula:C38H34F2N8O3Cor e Forma:SolidPeso molecular:688.725αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Cor e Forma:SolidPeso molecular:477.52Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:100%Cor e Forma:SoildPeso molecular:644.56Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Fórmula:C27H38N8O6Pureza:98%Cor e Forma:SolidPeso molecular:570.651CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Cor e Forma:SolidPeso molecular:408.46CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Fórmula:C30H23N5Cor e Forma:SolidPeso molecular:453.5411α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFórmula:C28H40O7Pureza:98%Cor e Forma:SolidPeso molecular:488.61Ara-G
CAS:Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.Fórmula:C10H13N5O5Pureza:99.93%Cor e Forma:Slightly Off White To White PowderPeso molecular:283.24Sorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Fórmula:C11H13BrN2O6Pureza:97.33%Cor e Forma:SolidPeso molecular:349.13Apcin A HCL
CAS:Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.Fórmula:C10H15Cl4N5O2Pureza:99.59%Cor e Forma:SolidPeso molecular:379.07AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Fórmula:C24H26F3N7O2Pureza:99.59%Cor e Forma:SolidPeso molecular:501.5Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Cor e Forma:SolidPeso molecular:464.59AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Fórmula:C17H19F3N4O3SPureza:99.96%Cor e Forma:SolidPeso molecular:416.42WRN inhibitor 16
WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.Fórmula:C31H30F4N4O5SCor e Forma:SolidPeso molecular:646.65CDK9-IN-7
CAS:CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Fórmula:C29H37N7O2SPureza:98.19%Cor e Forma:SolidPeso molecular:547.71Ref: TM-T10745
1mg116,00€5mg298,00€10mg432,00€25mg652,00€50mg900,00€100mg1.206,00€500mg2.432,00€1mL*10mM (DMSO)325,00€Penpulimab
CAS:Penpulimab is a monoclonal antibody targeting PD-1 with antitumor activity, used in studies of pancreatic cancer.Pureza:95% - 95%Cor e Forma:LiquidTadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Cor e Forma:LiquidAurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Cor e Forma:SolidPeso molecular:529.97
