Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
Exibir 11 mais subcategorias
Produtos da "Ciclo celular/Ponto de verificação"
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TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Cor e Forma:SolidPeso molecular:337.81T025
CAS:T025 inhibits CLK1-4 (Kds: 0.074-6.5 nM), shows anti-cancer effects (IC50: 30-300 nM), useful for MYC-related disease research.Fórmula:C21H18N8Pureza:98.08%Cor e Forma:SolidPeso molecular:382.42Ref: TM-T13058
1mg143,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Fórmula:C29H26FN5O4SPureza:97.45% - 98.44%Cor e Forma:SolidPeso molecular:559.61Ref: TM-T8487
1mg90,00€5mg183,00€10mg275,00€25mg449,00€50mg615,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)245,00€CDK2 degrader 4
CAS:CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Fórmula:C23H26ClN3O5Cor e Forma:SolidPeso molecular:459.923Adebrelimab
CAS:Adebrelimab (SHR-1316) is a humanized monoclonal antibody targeting PD-L1 with antitumor activity for the study of solid tumors.Pureza:95% - 95%Cor e Forma:LiquidCHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:98.02%Cor e Forma:SoildPeso molecular:480.75BT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Pureza:98%Cor e Forma:Odour Solid2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine
CAS:2'-Amino-2'-deoxy-b-D-arabino-5-methyl uridine is a purine nucleoside analog with potential antitumor activity.Fórmula:C10H15N3O5Pureza:96.76%Cor e Forma:SolidPeso molecular:257.24AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.88%Cor e Forma:SolidPeso molecular:456.37Cdk1/2 Inhibitor III
CAS:Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Fórmula:C15H13F2N7O2S2Pureza:100%Cor e Forma:SolidPeso molecular:425.44Ref: TM-T14914
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Cor e Forma:SolidPeso molecular:393.89Ref: TM-T23917
1mg65,00€5mg140,00€10mg216,00€25mg439,00€50mg707,00€100mg1.130,00€1mL*10mM (DMSO)156,00€IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Fórmula:C24H24N2O6Pureza:98%Cor e Forma:SolidPeso molecular:436.46Isoguanine
CAS:Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.Fórmula:C5H5N5OPureza:99.90%Cor e Forma:SolidPeso molecular:151.13Vidarabine
CAS:Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.Fórmula:C10H13N5O4Pureza:100%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:267.24Rac1 Inhibitor F56, control peptide acetate
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe.Fórmula:C74H120N18O25SPureza:98%Cor e Forma:SolidPeso molecular:1692.94Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Fórmula:C24H28Cl2N2O3S2Cor e Forma:SolidPeso molecular:527.53rel-(2S,3R)-Voruciclib hydrochloride
CAS:Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.Fórmula:C22H20Cl2F3NO5Pureza:98%Cor e Forma:SolidPeso molecular:506.3CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Cor e Forma:SolidPeso molecular:400.47Ref: TM-T3195
1mg44,00€2mg55,00€5mg88,00€10mg118,00€25mg208,00€50mg380,00€100mg565,00€1mL*10mM (DMSO)88,00€Prolgolimab
CAS:Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.Pureza:>95%Cor e Forma:Liquid6-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Fórmula:C11H15N5O5Pureza:97.50%Cor e Forma:SolidPeso molecular:297.27Lysidine
CAS:Lysidine (2-Methyl-2-iMidazoline) is a nucleoside rarely seen outside of tRNA. Lysidine has better translation fidelity.Fórmula:C4H8N2Pureza:98%Cor e Forma:Light Yellow To Off-White CrystallinePeso molecular:84.12Trifluridine
CAS:Trifluridine is a fluorinated thymidine analog with antineoplastic and antiviral properties, disrupting DNA and protein synthesis, leading to apoptosis.Fórmula:C10H11F3N2O5Pureza:99.39% - 99.82%Cor e Forma:White Crystalline PowderPeso molecular:296.2Haspin-IN-3
CAS:Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.Fórmula:C16H10N2O3Pureza:98.78%Cor e Forma:SolidPeso molecular:278.261-Methylcytosine
CAS:1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired withFórmula:C5H7N3OPureza:100%Cor e Forma:SolidPeso molecular:125.13MM41
CAS:MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.Fórmula:C44H66N10O6Pureza:97.13%Cor e Forma:SolidPeso molecular:831.06Ref: TM-T60028
1mg52,00€5mg116,00€10mg178,00€25mg293,00€50mg393,00€100mg520,00€200mg712,00€1mL*10mM (DMSO)160,00€Kira8
CAS:Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).Fórmula:C31H29ClN6O3SPureza:98.07%Cor e Forma:SolidPeso molecular:601.12Ref: TM-T11762L
1mg87,00€5mg202,00€10mg305,00€25mg567,00€50mg810,00€100mg1.111,00€1mL*10mM (DMSO)269,00€SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Fórmula:C20H27ClN8OSPureza:98.29%Cor e Forma:SolidPeso molecular:463Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Fórmula:C7H7NO4Pureza:96.85%Cor e Forma:SolidPeso molecular:169.13DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS:DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.Fórmula:C41H49N4O9PPureza:98.28%Cor e Forma:SolidPeso molecular:772.82HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Fórmula:C22H20N2O5SPureza:100% - 98.63%Cor e Forma:SolidPeso molecular:424.47Ref: TM-T2438
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)92,00€Durvalumab
CAS:Durvalumab is a humanized antibody for cancer, inhibiting PD-L1/PD-1 and CD80 interactions at very low concentrations.Pureza:SDS-PAGE:97.2%;SEC-HPLC:95.3%Cor e Forma:LiquidPeso molecular:146.03 kDaILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Fórmula:C30H30F3N5OPureza:99.30%Cor e Forma:SolidPeso molecular:533.59Ref: TM-T5488
1mg48,00€5mg97,00€10mg128,00€25mg162,00€50mg192,00€100mg281,00€200mg408,00€1mL*10mM (DMSO)137,00€Tibremciclib
CAS:Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].Fórmula:C28H32F2N8Pureza:98%Cor e Forma:SolidPeso molecular:518.6MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Cor e Forma:SolidPeso molecular:377.46Ref: TM-T22106
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Cor e Forma:SolidPeso molecular:464.56Ref: TM-T6785
1mg49,00€5mg97,00€10mg153,00€25mg296,00€50mg445,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)97,00€CASIN
CAS:CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Fórmula:C20H22N2OPureza:100% - 99.86%Cor e Forma:SolidPeso molecular:306.4Ref: TM-T3971
1mg38,00€2mg49,00€5mg74,00€10mg120,00€25mg188,00€50mg283,00€100mg435,00€500mg938,00€1mL*10mM (DMSO)74,00€Kaempferitrin
CAS:Kaempferitrin has antidepressant effects via 5-HT1A, targets HeLa cells, promotes glucose control, and boosts immune function, including NK cells.Fórmula:C27H30O14Pureza:98% - 99.59%Cor e Forma:SolidPeso molecular:578.52Ref: TM-T3386
1mg50,00€5mg123,00€10mg207,00€25mg349,00€50mg515,00€100mg735,00€500mg1.483,00€1mL*10mM (DMSO)156,00€Nolatrexed
CAS:Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.Fórmula:C14H12N4OSPureza:97.91%Cor e Forma:SolidPeso molecular:284.34Ref: TM-T4228
1mg42,00€2mg50,00€5mg90,00€10mg148,00€25mg240,00€50mg430,00€100mg633,00€1mL*10mM (DMSO)96,00€BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Fórmula:C21H20N4O2Pureza:98.87% - 99.53%Cor e Forma:SolidPeso molecular:360.41Reozalimab
CAS:Rezilimab is a bispecific antibody that targets PD-1/PD-L1 and mediates antibody-dependent cell cytotoxicity (ADCC) in cancer research [1] [2].Pureza:98%Cor e Forma:LiquidN1-Methylpseudouridine-5'-triphosphate
CAS:N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.Fórmula:C10H17N2O15P3Pureza:98.18%Cor e Forma:SolidPeso molecular:498.17BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:95.83% - 99.88%Cor e Forma:SolidPeso molecular:431.29Ref: TM-T4598
1mg43,00€2mg55,00€5mg84,00€10mg123,00€25mg198,00€50mg298,00€100mg444,00€1mL*10mM (DMSO)92,00€Fialuridine
CAS:Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.Fórmula:C9H10FIN2O5Pureza:99.71% - 99.90%Cor e Forma:Less Crystals Colourless CrystalsPeso molecular:372.09Ref: TM-T7655
1mg35,00€5mg74,00€10mg116,00€25mg235,00€50mg373,00€100mg562,00€500mg1.216,00€1mL*10mM (DMSO)82,00€CDK4/6-IN-24
CAS:CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.Fórmula:C32H41N7O3Cor e Forma:SolidPeso molecular:571.713Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.40%Cor e Forma:SolidPeso molecular:569.44Ref: TM-T30751
10g9.508,00€1mg74,00€5mg160,00€10mg264,00€25mg528,00€50mg785,00€100mg1.130,00€200mg1.549,00€1mL*10mM (DMSO)170,00€1ACTA
CAS:1ACTA (IRE1αS-nitrosylation inhibitor) is a compound that helps maintain the endoplasmic reticulum stress response under conditions of nitrosative stress.Fórmula:C14H16N2O2Cor e Forma:SolidPeso molecular:244.29NRTT-IN-1
CAS:NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.Fórmula:C28H24FN5O5Cor e Forma:SolidPeso molecular:529.519PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Cor e Forma:SolidPeso molecular:501.5
