Chk
Os inibidores da quinase de checkpoint (Chk) têm como alvo as quinasas Chk1 e Chk2, que são reguladoras-chave da resposta aos danos no DNA e dos pontos de verificação do ciclo celular. Essas quinasas interrompem a progressão do ciclo celular em resposta a danos no DNA, permitindo tempo para reparo. Inibir as quinasas Chk pode impedir a parada do ciclo celular, forçando as células danificadas a prosseguir no ciclo e, eventualmente, sofrer apoptose. Os inibidores de Chk são particularmente valiosos na pesquisa do câncer, onde podem sensibilizar as células tumorais a agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma variedade de inibidores de Chk de alta qualidade para apoiar sua pesquisa em resposta a danos no DNA, regulação do ciclo celular e oncologia.
Produtos da "Chk"
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CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Cor e Forma:SolidPeso molecular:408.46GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Cor e Forma:SolidPeso molecular:378.27CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:98.02%Cor e Forma:SoildPeso molecular:480.75CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:97.06% - 99.69%Cor e Forma:SolidPeso molecular:379.34Ref: TM-T7080
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg225,00€50mg369,00€100mg552,00€1mL*10mM (DMSO)92,00€VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Fórmula:C18H22BrN5O3Pureza:98.86% - 99.63%Cor e Forma:SolidPeso molecular:436.3CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg185,00€2mg279,00€5mg424,00€10mg627,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)470,00€CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Fórmula:C18H19ClFN5OSPureza:100%Cor e Forma:SolidPeso molecular:407.89SB-218078
CAS:SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM).Fórmula:C24H15N3O3Pureza:98%Cor e Forma:SolidPeso molecular:393.39ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Fórmula:C13H8Cl2N2Pureza:99.21%Cor e Forma:SolidPeso molecular:263.12PHI-101
CAS:PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.Fórmula:C19H19FN4O2SPureza:99.40%Cor e Forma:SolidPeso molecular:386.44Ref: TM-T81490
1mg173,00€5mg437,00€10mg702,00€25mg1.406,00€50mg2.262,00€100mg3.600,00€1mL*10mM (DMSO)469,00€SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Cor e Forma:SolidPeso molecular:376.25Ref: TM-T2517
1mg52,00€2mg78,00€5mg115,00€10mg168,00€25mg283,00€50mg462,00€100mg660,00€1mL*10mM (DMSO)124,00€AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Cor e Forma:SolidPeso molecular:362.42Ref: TM-T6093
1mg38,00€2mg49,00€5mg81,00€10mg96,00€25mg177,00€50mg280,00€100mg449,00€1mL*10mM (DMSO)88,00€SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.95%Cor e Forma:SolidPeso molecular:376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€CHK1-IN-4
CAS:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Fórmula:C18H18BrN7O2Pureza:98%Cor e Forma:SolidPeso molecular:444.29LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Fórmula:C19H23N7O2Pureza:99.77%Cor e Forma:SolidPeso molecular:381.43Ref: TM-T9252
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)316,00€CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Fórmula:C17H21BrN4OPureza:98%Cor e Forma:SolidPeso molecular:377.28CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H28ClFN4O4Pureza:97.13%Cor e Forma:SolidPeso molecular:478.95Ref: TM-T10718L
1mg73,00€2mg96,00€5mg159,00€10mg240,00€25mg515,00€50mg852,00€100mg1.264,00€500mg2.547,00€1mL*10mM (DMSO)170,00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48
