Integrinas
Os inibidores de integrinas têm como alvo as integrinas, uma família de receptores de superfície celular que desempenham um papel crucial na adesão celular, migração e transdução de sinais. As integrinas estão envolvidas na regulação do ciclo celular, particularmente em processos como divisão e diferenciação celular. Inibir integrinas pode interromper esses processos, levando à parada do ciclo celular e apoptose, tornando esses inibidores valiosos na pesquisa do câncer e no estudo da metástase. Na CymitQuimica, oferecemos uma ampla gama de inibidores de integrinas de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, biologia do câncer e desenvolvimento terapêutico.
Produtos da "Integrinas"
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Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Fórmula:C29H42F3N9O9Pureza:98.99% - 99.54%Cor e Forma:SolidPeso molecular:717.69Volociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Pureza:95%Cor e Forma:LiquidBIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Fórmula:C36H48N6O9Pureza:99.33%Cor e Forma:SolidPeso molecular:708.8Bexotegrast
CAS:Bexotegrast (PLN-74809) is an αvβ6 and αvβ1 integrin inhibitor with antifibrotic properties for the study of idiopathic pulmonary fibrosis (IPF).Fórmula:C27H36N6O3Pureza:99.53%Cor e Forma:SolidPeso molecular:492.61Indatuximab
Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.Cor e Forma:LiquidPeso molecular:145.5 kDaBMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Fórmula:C26H19Cl2N5O4Pureza:98.87%Cor e Forma:SolidPeso molecular:536.37Ref: TM-T14676
1mg183,00€5mg464,00€10mg655,00€25mg1.169,00€50mg1.539,00€100mg1.882,00€1mL*10mM (DMSO)547,00€Azelaoyl PAF
CAS:Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Fórmula:C33H66NO9PCor e Forma:SolidPeso molecular:651.85Abciximab
CAS:Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Pureza:SDS-PAGE:95.2%;SEC-HPLC:95.9%Cor e Forma:LiquidPeso molecular:95.18 kDaαVβ8-IN-1
CAS:αVβ8-IN-1 is an inhibitor of the αVβ8 integrin. It exhibits growth-suppressive activity against tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 is suitable for research related to idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and various cancers.Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.01Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidBimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Cor e Forma:SolidPeso molecular:862.91Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Fórmula:C29H41F3N8O9Cor e Forma:SolidPeso molecular:702.68Blinatumomab
CAS:Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Cor e Forma:LiquidSynstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Fórmula:C29H37N7O5SPureza:100% - 99.70%Cor e Forma:SolidPeso molecular:595.71α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Fórmula:C23H29N3O6SPureza:98%Cor e Forma:SolidPeso molecular:475.56Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Fórmula:C32H38O19Pureza:99.16% - 99.97%Cor e Forma:SolidPeso molecular:726.63Abrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Cor e Forma:LiquidEgaptivon pegol
CAS:Egaptivon pegol (ARC1779) is an aptamer that inhibits the interaction of von Willebrand Factor (VWF) with platelet GPIb receptors, exhibiting anti-thromboticPureza:98%Cor e Forma:LiquidBI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Fórmula:C32H26Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:646.5Gantofiban
CAS:Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Fórmula:C21H29N5O6Pureza:99.21%Cor e Forma:SolidPeso molecular:447.48iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Fórmula:C35H57N13O14S2Pureza:98.77%Cor e Forma:SolidPeso molecular:948.04STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:95% - 95%Cor e Forma:Odour LiquidC16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Cor e Forma:SolidPeso molecular:1562.85KOdiA-PC
CAS:KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.Fórmula:C32H58NO11PCor e Forma:SolidPeso molecular:663.78Efalizumab
CAS:Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.Pureza:SDS-PAGE:95% SEC-HPLC:98.77%Cor e Forma:LiquidPeso molecular:146.14 kDaObtustatin triacetate
Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of theFórmula:C184H284N52O57S8·3C2H4O2Pureza:99.51%Cor e Forma:SolidPeso molecular:4573.21ICAM-1-IN-1
CAS:ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Fórmula:C15H11BrN2O2SPureza:99.34%Cor e Forma:SolidPeso molecular:363.23Ref: TM-T13147
1mg185,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Fórmula:C46H52Na2O16Pureza:98%Cor e Forma:SolidPeso molecular:906.88GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Fórmula:C29H37N5O2xHClPureza:99.54%Cor e Forma:SolidPeso molecular:0Tirofiban hydrochloride monohydrate
CAS:Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Fórmula:C22H39ClN2O6SPureza:95.83% - 99.94%Cor e Forma:White SolidPeso molecular:495.07Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:98.00%Cor e Forma:LiquidPeso molecular:N/AH-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Fórmula:C23H38N10O10Pureza:100%Cor e Forma:SolidPeso molecular:614.61Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.10% - 99.33%Cor e Forma:SolidPeso molecular:558.7αvβ1 integrin-IN-2
CAS:αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Fórmula:C29H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:506.64A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Fórmula:C15H12N2OS2Pureza:98.07% - 98.52%Cor e Forma:SolidPeso molecular:300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Fórmula:C30H30F3N5OPureza:98.03%Cor e Forma:SolidPeso molecular:533.59Ref: TM-T5485
1mg97,00€2mg144,00€5mg235,00€10mg378,00€25mg647,00€50mg920,00€100mg1.225,00€500mg2.498,00€1mL*10mM (DMSO)306,00€RO0270608
CAS:RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Fórmula:C24H19Cl3N2O4Pureza:98.55%Cor e Forma:SolidPeso molecular:505.78Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:≥95%Cor e Forma:SolidPeso molecular:847.72αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Cor e Forma:SolidPeso molecular:477.52Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:100%Cor e Forma:SoildPeso molecular:644.56Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:97.81%Cor e Forma:SolidPeso molecular:451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€Tadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Cor e Forma:LiquidBT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Pureza:98%Cor e Forma:Odour SolidCilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Cor e Forma:SolidPeso molecular:588.66Ref: TM-T2494
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg274,00€50mg439,00€100mg632,00€1mL*10mM (DMSO)137,00€Etaracizumab
CAS:Etaracizumab (LM 609) is a humanized monoclonal antibody targeting integrin αvβ3, inhibiting angiogenesis and melanoma growth, used in the study of melanoma.Pureza:>95% - >95%Cor e Forma:LiquidPeso molecular:144.3 (kDa)Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.40%Cor e Forma:SolidPeso molecular:569.44Ref: TM-T30751
10g9.508,00€1mg74,00€5mg160,00€10mg264,00€25mg528,00€50mg785,00€100mg1.130,00€200mg1.549,00€1mL*10mM (DMSO)170,00€Cyclo(-RGDfK)
CAS:Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Fórmula:C27H41N9O7Pureza:100% - 99.83%Cor e Forma:SolidPeso molecular:603.67PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Fórmula:C24H37N3O4Pureza:99.25%Cor e Forma:SoildPeso molecular:431.57Ref: TM-T60101
1mg52,00€5mg111,00€10mg180,00€25mg305,00€50mg439,00€100mg612,00€1mL*10mM (DMSO)124,00€
