c-Myc
Os inibidores de c-Myc têm como alvo a proteína c-Myc, um fator de transcrição que desempenha um papel crucial no crescimento celular, proliferação e apoptose. c-Myc regula a expressão de numerosos genes envolvidos no ciclo celular e é frequentemente superexpresso em vários tipos de câncer, levando a uma proliferação celular descontrolada e ao crescimento tumoral. Inibir o c-Myc pode interromper esses processos, induzindo a parada do ciclo celular e a apoptose em células cancerígenas. Os inibidores de c-Myc são ferramentas importantes na pesquisa do câncer e no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de c-Myc de alta qualidade para apoiar sua pesquisa em oncologia, regulação do ciclo celular e controle transcricional.
Produtos da "c-Myc"
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44 produtos desta categoria.
KSI-3716
CAS:KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.Fórmula:C17H11BrCl2N2O2Pureza:98.94%Cor e Forma:SolidPeso molecular:426.09BRD4 Inhibitor-40
CAS:BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.Fórmula:C27H32N8OCor e Forma:SolidPeso molecular:484.596β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Fórmula:C15H12ClN3O2SCor e Forma:SolidPeso molecular:333.79NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFórmula:C38H43N3O6Pureza:99.16% - 99.27%Cor e Forma:SolidPeso molecular:637.76Ref: TM-T9093
1mg87,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)264,00€Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Fórmula:C37H46O12Pureza:99.06% - ≥95%Cor e Forma:SolidPeso molecular:682.7510058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Fórmula:C12H11NOS2Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:249.35WBC100
CAS:WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathwayFórmula:C25H33NO7Pureza:98%Cor e Forma:SolidPeso molecular:459.53Lusianthridin
CAS:Lusianthridin is a natural product from Dendrobium venustum.Fórmula:C15H14O3Pureza:99.11% - 99.11%Cor e Forma:SolidPeso molecular:242.272-5A-dependent Rnase Protein, Human, Recombinant (Myc)
2-5A-dependent Rnase Protein, Human, Recombinant (Myc) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:85.1 kDa (predicted)MYC-RIBOTAC
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tetheredFórmula:C55H58N10O11SPureza:98%Cor e Forma:SolidPeso molecular:1067.17Saxagliptin hydrate
CAS:Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Fórmula:C18H25N3O2·H2OPureza:99.52%Cor e Forma:SolidPeso molecular:333.43APTO-253
CAS:APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.Fórmula:C22H14FN5Pureza:98.73%Cor e Forma:SolidPeso molecular:367.38Ref: TM-T10352
1mg43,00€2mg55,00€5mg80,00€10mg101,00€25mg180,00€50mg284,00€100mg411,00€200mg597,00€1mL*10mM (DMSO)88,00€c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Fórmula:C22H24N6OPureza:98%Cor e Forma:SolidPeso molecular:388.4710074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFórmula:C18H14Cl2N2O3SPureza:98.01%Cor e Forma:SolidPeso molecular:409.29Ref: TM-T9628
1mg71,00€5mg135,00€10mg197,00€25mg335,00€50mg480,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)156,00€PARL Protein, Human, Recombinant (Myc)
Required for the control of apoptosis during postnatal growth.Cor e Forma:Lyophilized PowderPeso molecular:37.8 kDa (predicted)MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Fórmula:C25H16Cl2F6N2O2Pureza:99.3% - 99.58%Cor e Forma:SolidPeso molecular:561.310074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Fórmula:C18H12N4O3Pureza:97.22% - 99.67%Cor e Forma:SolidPeso molecular:332.31Ref: TM-T3686
2mg42,00€5mg63,00€10mg88,00€25mg142,00€50mg225,00€100mg396,00€200mg565,00€500mg900,00€1mL*10mM (DMSO)69,00€Artemisitene
CAS:Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Fórmula:C15H20O5Pureza:99.58%Cor e Forma:SolidPeso molecular:280.32Ref: TM-T21065
1mg95,00€5mg187,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€1mL*10mM (DMSO)281,00€Nicotinamide N-oxide
CAS:Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Fórmula:C6H6N2O2Pureza:99.61% - 99.9%Cor e Forma:SolidPeso molecular:138.12Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Fórmula:C26H27NO9·HClPureza:100% - 99.93%Cor e Forma:SolidPeso molecular:533.95m-Se3
CAS:m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Fórmula:C29H23IN2SePureza:98%Cor e Forma:SolidPeso molecular:605.37MYCi361
CAS:MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Fórmula:C26H16ClF9N2O2Pureza:99.52%Cor e Forma:SolidPeso molecular:594.86sAJM589
CAS:sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Fórmula:C16H10N2OPureza:98%Cor e Forma:SolidPeso molecular:246.26(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Cor e Forma:SolidPeso molecular:364.35ACOX1 Protein, Mouse, Recombinant (Myc)
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.Cor e Forma:Lyophilized PowderPeso molecular:76.2 kDa (predicted)KJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Fórmula:C22H15N3O4Pureza:98.07% - ≥98%Cor e Forma:SolidPeso molecular:385.37Ref: TM-T15665
2mg39,00€5mg57,00€10mg81,00€25mg145,00€50mg279,00€100mg510,00€200mg683,00€500mg1.064,00€1mL*10mM (DMSO)63,00€CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Fórmula:C48H50F9N7O7SCor e Forma:SolidPeso molecular:1040IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Fórmula:C13H11Cl2NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:316.14Ref: TM-T40419
1mg103,00€5mg246,00€10mg395,00€25mg785,00€50mg1.198,00€100mg1.853,00€200mg2.498,00€1mL*10mM (DMSO)271,00€EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Fórmula:C25H24N2O4Pureza:98.51%Cor e Forma:SolidPeso molecular:416.47Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Fórmula:C24H17ClF2N6O4Pureza:97.87% - 99.51%Cor e Forma:SolidPeso molecular:526.88Ref: TM-T4367
1mg49,00€5mg99,00€10mg168,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)116,00€MDEG-541
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].Fórmula:C35H38N4O7SPureza:98%Cor e Forma:SolidPeso molecular:658.76c-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFórmula:C20H22N6OPureza:98%Cor e Forma:SolidPeso molecular:362.43BTYNB
CAS:BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1. MDK6620 downregulates β-TrCP1 mRNA and reduces activation of NF-κB.Fórmula:C12H9BrN2OSPureza:99.91% - ≥95%Cor e Forma:SolidPeso molecular:309.18Ref: TM-T9033
5mg48,00€10mg63,00€25mg93,00€50mg136,00€100mg198,00€200mg309,00€500mg563,00€1mL*10mM (DMSO)50,00€MYCMI-6
CAS:MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.Fórmula:C20H19N7OPureza:99.23%Cor e Forma:SolidPeso molecular:373.41Ref: TM-T12134
1mg74,00€5mg160,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€200mg1.026,00€500mg1.510,00€VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Fórmula:C16H12F6N2SPureza:99.93%Cor e Forma:SolidPeso molecular:378.34Ref: TM-T60019
1mg51,00€5mg106,00€10mg160,00€25mg283,00€50mg406,00€100mg592,00€200mg835,00€1mL*10mM (DMSO)137,00€FIDAS-3
CAS:FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activitiesFórmula:C16H15F2NPureza:97.75%Cor e Forma:SolidPeso molecular:259.29Ref: TM-T11284
5mg52,00€10mg78,00€25mg134,00€50mg192,00€100mg279,00€200mg374,00€1mL*10mM (DMSO)50,00€Eragidomide
CAS:Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.Fórmula:C22H18ClF2N3O4Pureza:97.51% - 99.63%Cor e Forma:SolidPeso molecular:461.85Saxagliptin
CAS:Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.Fórmula:C18H25N3O2Pureza:98.05% - 99.95%Cor e Forma:SolidPeso molecular:315.41FIDAS-5
CAS:FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Fórmula:C15H13ClFNPureza:97.66% - 98.3%Cor e Forma:SolidPeso molecular:261.72Ref: TM-T11285
1mg59,00€2mg85,00€5mg116,00€10mg187,00€25mg331,00€50mg512,00€100mg740,00€500mg1.415,00€Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Fórmula:C17H16O4Pureza:98.31% - ≥95%Cor e Forma:SolidPeso molecular:284.31Aaptamine
CAS:Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.Fórmula:C13H12N2O2Pureza:98%Cor e Forma:SolidPeso molecular:228.25Ceramides Mixture
CAS:Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.Fórmula:C36H71NO4Pureza:98%Cor e Forma:SolidPeso molecular:581.967NNK
CAS:NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.Cost-effective and quality-assured.Fórmula:C10H13N3O2Pureza:98.89% - 99.86%Cor e Forma:SolidPeso molecular:207.23Ref: TM-T20533
5mg60,00€10mg96,00€25mg159,00€50mg227,00€100mg274,00€200mg406,00€500mg652,00€1mL*10mM (DMSO)65,00€ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Fórmula:C19H18N4O4Pureza:99.48%Cor e Forma:SolidPeso molecular:366.37
