HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Produtos da "HSP"
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Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Fórmula:C20H20N4O3Pureza:97.29% - 99.95%Cor e Forma:SolidPeso molecular:364.4Ref: TM-T2309
5mg66,00€10mg87,00€25mg133,00€50mg166,00€100mg250,00€200mg424,00€500mg702,00€1mL*10mM (DMSO)74,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Fórmula:C23H38OPureza:99.76% - 99.96%Cor e Forma:SolidPeso molecular:330.55SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.9% - 99.98%Cor e Forma:SolidPeso molecular:429.85Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Fórmula:C32H48N4O8·HClPureza:99.94%Cor e Forma:SolidPeso molecular:653.21JG-231
CAS:JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.Fórmula:C22H18BrCl2N3OS4Pureza:99.21%Cor e Forma:SolidPeso molecular:619.47DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Fórmula:C25H29N5O4SPureza:99.81%Cor e Forma:SolidPeso molecular:495.59Ref: TM-T9202
1mg37,00€5mg80,00€10mg126,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)88,00€HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Fórmula:C26H27ClN4O2Pureza:97.15%Cor e Forma:SolidPeso molecular:462.97L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Fórmula:C8H15N3O4Pureza:99.71% - 99.97%Cor e Forma:SolidPeso molecular:217.22Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Fórmula:C16H32O2Pureza:99.17% - 99.67%Cor e Forma:White Crystalline Scales SolidPeso molecular:256.42C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Fórmula:C29H28O8Cor e Forma:SolidPeso molecular:504.53HSP90-IN-27
CAS:HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Fórmula:C18H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:343.44Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Fórmula:C32H48N4O8Pureza:100%Cor e Forma:SolidPeso molecular:616.75NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Fórmula:C32H32FN5O4Pureza:99.26%Cor e Forma:SolidPeso molecular:569.63Ref: TM-T9804
1mg96,00€5mg240,00€10mg375,00€25mg627,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)300,00€Radicicol
CAS:Radicicol is an antifungal antibiotic, a inhibitor of Hsp90 & FTO, Anti-malarial , inhibits iNOS gene expression by blocking the p38 kinase and NF-κB/Rel.Fórmula:C18H17ClO6Pureza:98%Cor e Forma:White/Yellow PowderPeso molecular:364.78Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFórmula:C28H34O5Pureza:99.52% - 99.52%Cor e Forma:SolidPeso molecular:450.57Ref: TM-TN6729
1mg131,00€5mg286,00€10mg515,00€25mg777,00€50mg1.074,00€100mg1.454,00€1mL*10mM (DMSO)354,00€GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.11%Cor e Forma:SoildPeso molecular:342.42IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:100%Cor e Forma:SolidPeso molecular:545.62VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Fórmula:C19H18ClN3O4Pureza:99.36% - 99.99%Cor e Forma:SolidPeso molecular:387.82Ref: TM-T3454
2mg46,00€5mg64,00€10mg92,00€25mg164,00€50mg259,00€100mg354,00€200mg500,00€1mL*10mM (DMSO)52,00€Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Fórmula:C25H26N8OPureza:99.22% - 99.49%Cor e Forma:SolidPeso molecular:454.53
