Receptor de Androgénio
O receptor de andrógenos (AR) é um receptor hormonal nuclear que é ativado pela ligação a andrógenos, como a testosterona e a diidrotestosterona. Este receptor desempenha um papel crucial no desenvolvimento e na manutenção das características masculinas, bem como na regulação de vários processos fisiológicos, incluindo o crescimento muscular, a libido e a densidade óssea. Inibidores do receptor de andrógenos são amplamente estudados no contexto do câncer de próstata, onde a sinalização do AR é frequentemente aumentada. Na CymitQuimica, oferecemos uma gama de moduladores do receptor de andrógenos de alta qualidade para apoiar sua pesquisa em endocrinologia, biologia do câncer e regulação hormonal.
Produtos da "Receptor de Androgénio"
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AR antagonist 10
CAS:AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Fórmula:C18H17ClN4O3SCor e Forma:SolidPeso molecular:404.871Dehydroisoandrosterone 3-acetate
CAS:Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Fórmula:C21H30O3Pureza:100% - 99.81%Cor e Forma:SolidPeso molecular:330.46ONC1-13B
CAS:ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Fórmula:C22H16F4N4O3SPureza:99.45% - 99.85%Cor e Forma:SolidPeso molecular:492.45ARD-2585
CAS:ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Fórmula:C41H43ClN8O5Cor e Forma:SolidPeso molecular:763.28LY2452473
CAS:LY2452473 (OPK 88004) is an orally available and selective androgen receptor modulator with potential anticancer activity for the study of prostate cancer.Fórmula:C22H22N4O2Pureza:99.72%Cor e Forma:SolidPeso molecular:374.44Ref: TM-T15804
1mg35,00€5mg74,00€10mg97,00€25mg149,00€50mg188,00€100mg281,00€200mg429,00€1mL*10mM (DMSO)81,00€p,p'-DDE
CAS:p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDTFórmula:C14H8Cl4Pureza:99.68%Cor e Forma:White Crystalline Solid Physical Description White Crystalline Solid Or White Powder (Ntp 1992)Peso molecular:318.03Androgen receptor antagonist 12
CAS:Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Fórmula:C12H8F3N3O2Cor e Forma:SolidPeso molecular:283.21LX1
CAS:LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Fórmula:C22H15F6NO2Cor e Forma:SolidPeso molecular:439.35CTK8A3536
CAS:CTK8A3536 ((2-MORPHOLIN-4-YL-4-PHENYL-1,3-THIAZOL-5-YL)METHANOL) is an inhibitor of Androgen receptor.Fórmula:C14H16N2O2SPureza:99.62%Cor e Forma:SolidPeso molecular:276.35Ref: TM-T8592
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)169,00€Pentomone
CAS:Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Fórmula:C24H26O5Cor e Forma:SolidPeso molecular:394.46Zanoterone
CAS:Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders andFórmula:C23H32N2O3SPureza:99.85% - 99.96%Cor e Forma:SoildPeso molecular:416.58Bavdegalutamide
CAS:Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).Fórmula:C41H43ClFN9O6Pureza:97.17% - 99.04%Cor e Forma:SolidPeso molecular:812.29ARD-2128
CAS:ARD-2128: potent oral PROTAC that degrades AR, curbing prostate cancer growth with no toxicity.Fórmula:C45H50ClN7O6Pureza:98.80%Cor e Forma:SolidPeso molecular:820.37Bifluranol
CAS:Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostaticFórmula:C17H18F2O2Pureza:99.77%Cor e Forma:SolidPeso molecular:292.32Gridegalutamide
CAS:Gridegalutamide exhibits anti-androgen and anti-tumor activities.Fórmula:C41H45F3N8O5SCor e Forma:SolidPeso molecular:818.91Vosilasarm
CAS:RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Fórmula:C20H16ClN5O2Pureza:99.01% - 99.6%Cor e Forma:A Crystalline SolidPeso molecular:393.82(+)-JJ-74-138
CAS:(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).Fórmula:C22H22F8N2OSCor e Forma:SolidPeso molecular:514.48YXG-158
CAS:YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Fórmula:C30H36FN3OPureza:98%Cor e Forma:SolidPeso molecular:473.62ACP-105
CAS:ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFórmula:C16H19ClN2OPureza:99.53%Cor e Forma:SolidPeso molecular:290.79Ref: TM-T14116
2mg38,00€5mg58,00€10mg90,00€25mg164,00€50mg226,00€100mg325,00€200mg455,00€1mL*10mM (DMSO)65,00€MI-136
CAS:MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.Fórmula:C23H21F3N6SPureza:97.08% - 98.63%Cor e Forma:SolidPeso molecular:470.51Ref: TM-T6889
1mg47,00€5mg87,00€10mg147,00€25mg279,00€50mg472,00€100mg730,00€200mg1.017,00€1mL*10mM (DMSO)97,00€
