NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
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JSH-23
CAS:JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.Fórmula:C16H20N2Pureza:98.03% - 99.67%Cor e Forma:SolidPeso molecular:240.34Ref: TM-T1930
1mg43,00€2mg57,00€5mg93,00€10mg119,00€25mg187,00€50mg283,00€100mg430,00€1mL*10mM (DMSO)93,00€Quinoclamine
CAS:Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.Fórmula:C10H6ClNO2Pureza:99.13% - 99.28%Cor e Forma:Orange PowderPeso molecular:207.617,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:SolidPeso molecular:254.24Emlenoflast sodium
CAS:Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome,Fórmula:C19H24N4NaO3SCor e Forma:SolidPeso molecular:411.47SjDX5-271
CAS:SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Fórmula:C137H215N47O49SCor e Forma:SolidPeso molecular:3336.52NF-κΒ activator 2
CAS:NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.Fórmula:C16H11FN2O3Pureza:99.32%Cor e Forma:SolidPeso molecular:298.27Ref: TM-T39924
1mg94,00€2mg136,00€5mg226,00€10mg335,00€25mg538,00€50mg730,00€100mg938,00€1mL*10mM (DMSO)249,00€HS-1371
CAS:HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.Fórmula:C24H24N4OPureza:98%Cor e Forma:SolidPeso molecular:384.47Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Fórmula:C6H9NOS2Pureza:98.01% - 99.19%Cor e Forma:Slightly Yellowish LiquidPeso molecular:175.27Ref: TM-TL0016
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)69,00€Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).Fórmula:C141H210N32O44SPureza:98%Cor e Forma:SolidPeso molecular:3089.43CORM-3
CAS:CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.Fórmula:C5H4ClNO5RuPureza:98%Cor e Forma:SolidPeso molecular:294.61NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Cor e Forma:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€Indacaterol
CAS:Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.Fórmula:C24H28N2O3Pureza:100.00% - 99.63%Cor e Forma:SolidPeso molecular:392.49Sulfuretin
CAS:Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.Fórmula:C15H10O5Pureza:100% - 98.91%Cor e Forma:SolidPeso molecular:270.24WITHAFERIN A
CAS:WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Fórmula:C28H38O6Pureza:97.41% - 99.83%Cor e Forma:SolidPeso molecular:470.6Ref: TM-T5687
1mg85,00€5mg265,00€10mg393,00€25mg653,00€50mg929,00€100mg1.254,00€500mg2.517,00€1mL*10mM (DMSO)304,00€IRAK4-IN-28
CAS:IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.Fórmula:C27H31N9O3Pureza:98%Cor e Forma:SolidPeso molecular:529.59Isonardosinone
CAS:Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities.Fórmula:C15H22O3Pureza:98%Cor e Forma:SolidPeso molecular:250.33GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Fórmula:C17H17BrF3N7O2SPureza:99.46% - ≥98%Cor e Forma:SolidPeso molecular:520.33Ref: TM-T5540
1mg47,00€2mg59,00€5mg92,00€10mg131,00€25mg215,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)96,00€Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Fórmula:C42H72O13Pureza:99.5% - 99.77%Cor e Forma:SolidPeso molecular:785.01Ref: TM-T2873
2mg37,00€5mg52,00€10mg88,00€25mg131,00€50mg188,00€100mg279,00€500mg658,00€1mL*10mM (DMSO)87,00€Pratensein
CAS:Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Fórmula:C16H12O6Pureza:99.72%Cor e Forma:SolidPeso molecular:300.26γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Cor e Forma:SolidPeso molecular:410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€Tyrosol
CAS:Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present mostFórmula:C8H10O2Pureza:100% - 99.28%Cor e Forma:SolidPeso molecular:138.16Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Fórmula:C40H52O4Pureza:95.1% - 99.79%Cor e Forma:Needles From Acetone/Light Petroleum SolidPeso molecular:596.84TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Fórmula:C17H17NOPureza:99.65%Cor e Forma:SolidPeso molecular:251.32Handelin
CAS:Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.Fórmula:C32H40O8Pureza:99.02%Cor e Forma:SolidPeso molecular:552.66RIPK2-IN-3
CAS:RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.Fórmula:C25H22N4O2Pureza:99.57%Cor e Forma:SolidPeso molecular:410.47GSK2983559 free acid
CAS:GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.Fórmula:C21H23N4O7PS2Pureza:97.87% - 98.61%Cor e Forma:SolidPeso molecular:538.53Narasin (sodium salt)
CAS:Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells andFórmula:C43H71NaO11Pureza:98%Cor e Forma:SolidPeso molecular:787.01Oditrasertib
CAS:Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Fórmula:C14H15F2N3O2Pureza:98.65% - 99.65%Cor e Forma:SolidPeso molecular:295.28Naringin dihydrochalcone
CAS:Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Fórmula:C27H34O14Pureza:99.07% - 99.16%Cor e Forma:Solid PowderPeso molecular:582.55Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Fórmula:C19H20O6Pureza:99.88%Cor e Forma:SolidPeso molecular:344.36NIK SMI1
CAS:NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Fórmula:C20H19N3O4Pureza:99.04% - 99.99%Cor e Forma:SolidPeso molecular:365.38Ref: TM-T16290
1mg87,00€5mg183,00€10mg296,00€25mg593,00€50mg932,00€100mg1.501,00€200mg2.052,00€1mL*10mM (DMSO)432,00€NDMC101
CAS:NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Fórmula:C13H9ClFNO2Pureza:99.89%Cor e Forma:SolidPeso molecular:265.67MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Fórmula:C26H36N6O2Pureza:99.25% - 99.79%Cor e Forma:SolidPeso molecular:464.6GSK481
CAS:GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.Fórmula:C21H19N3O4Pureza:98.97%Cor e Forma:SolidPeso molecular:377.39COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Cor e Forma:Odour SolidCOX-2-IN-32
CAS:COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Fórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Fórmula:C5H6N2OSPureza:100% - 99.89%Cor e Forma:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18α-Lipoic Acid
CAS:α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Fórmula:C8H14O2S2Pureza:98.39% - 99.73%Cor e Forma:Forms Yellowish Flakes Light Yellow To Yellow PowderPeso molecular:206.33Shikonin
CAS:Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Fórmula:C16H16O5Pureza:98.13% - 99.9%Cor e Forma:SolidPeso molecular:288.3Ref: TM-T1125
5mg34,00€10mg52,00€25mg87,00€50mg140,00€100mg215,00€200mg319,00€500mg533,00€1mL*10mM (DMSO)52,00€20(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Fórmula:C42H72O13Pureza:100% - 99.93%Cor e Forma:SolidPeso molecular:785.01UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Fórmula:C18H17N3OPureza:99.48%Cor e Forma:SolidPeso molecular:291.35Ref: TM-T88314
2mg38,00€5mg57,00€10mg92,00€25mg166,00€50mg254,00€100mg389,00€200mg566,00€1mL*10mM (DMSO)63,00€ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Fórmula:C32H22O10Pureza:98% - 99.72%Cor e Forma:SolidPeso molecular:566.51Denosumab
CAS:Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligandFórmula:C6404H9912N1724O2004S50Pureza:98.4% (SEC-HPLC) - 99.90%Cor e Forma:LiquidPeso molecular:144.71 kDaTrovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.12%Cor e Forma:SolidPeso molecular:512.46Selinidin
CAS:Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Fórmula:C19H20O5Pureza:98%Cor e Forma:SolidPeso molecular:328.364Biricodar dicitrate
CAS:Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.Fórmula:C46H57N3O21Pureza:98.67% - 99.34%Cor e Forma:SolidPeso molecular:987.95Ginsenoside Rg6
CAS:Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFórmula:C42H70O12Pureza:≥98%Cor e Forma:SolidPeso molecular:767Obtusifolin
CAS:Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Fórmula:C16H12O5Pureza:100% - 99.79%Cor e Forma:SolidPeso molecular:284.26Ref: TM-T4S0969
1mg70,00€5mg187,00€10mg279,00€25mg472,00€50mg658,00€100mg933,00€1mL*10mM (DMSO)187,00€Molsidomine
CAS:Molsidomine, an oral vasodilator, turns into linsidomine in the liver, releasing NO for prolonged effects.Fórmula:C9H14N4O4Pureza:100% - 99.98%Cor e Forma:Colorless Or White Crystalline PowderPeso molecular:242.23Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Fórmula:C13H21ClN2O3SPureza:99.76%Cor e Forma:White Crystalline PowderPeso molecular:320.846‴-Feruloylspinosin
CAS:6‴-Feruloylspinosin (6'''-Feruloylspinosin) may possess anti-inflammatory activity.Fórmula:C38H40O18Pureza:98.69% - 99.91%Cor e Forma:SolidPeso molecular:784.71Praeruptorin A
CAS:Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulinFórmula:C21H22O7Pureza:99.63% - 99.65%Cor e Forma:SolidPeso molecular:386.4ADS032
CAS:ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.Fórmula:C22H29NO4SPureza:99.33%Cor e Forma:SolidPeso molecular:403.54MCC950
CAS:CP-456773 (MCC950) inhibits NLRP3 inflammasome, prevents IL-1β secretion, and reduces multiple sclerosis model severity.Fórmula:C20H24N2O5SPureza:97%Cor e Forma:SolidPeso molecular:404.48Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Fórmula:C27H30O14Pureza:98.11% - 98.87%Cor e Forma:SolidPeso molecular:578.52Necroptosis-IN-1
CAS:Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.Fórmula:C12H10ClN3O2Pureza:99.60% - 99.73%Cor e Forma:SolidPeso molecular:263.68Ref: TM-T9305
1mg64,00€5mg117,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg840,00€1mL*10mM (DMSO)149,00€Neochlorogenic acid
CAS:Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.Fórmula:C16H18O9Pureza:99.12% - 99.73%Cor e Forma:White PowderPeso molecular:354.31ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Fórmula:C21H25ClN4O2Pureza:100%Cor e Forma:SolidPeso molecular:400.9Ref: TM-T10237
1mg66,00€5mg144,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€1mL*10mM (DMSO)159,00€IRAK inhibitor 6
CAS:IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).Fórmula:C20H20N4O3SPureza:99.44%Cor e Forma:SolidPeso molecular:396.46NT-0249
CAS:NT-0249 is an inflammatory vesicle NLRP3 inhibitor with anti-inflammatory activity that reverses high-fat diet-induced obesity.Fórmula:C22H28N5NaO4SCor e Forma:SoildPeso molecular:481.5411-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Ref: TM-TN1182
1mg60,00€5mg137,00€10mg210,00€25mg356,00€50mg525,00€100mg750,00€1mL*10mM (DMSO)140,00€RIPA-56
CAS:RIPA-56 is an inhibitor of RIP1Fórmula:C13H19NO2Pureza:99.53% - 99.95%Cor e Forma:SolidPeso molecular:221.3Ref: TM-T7795
5mg38,00€10mg52,00€25mg94,00€50mg136,00€100mg213,00€200mg316,00€500mg532,00€1mL*10mM (DMSO)55,00€oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Fórmula:C36H58O5Cor e Forma:SolidPeso molecular:570.84N,N-Dimethylacetamide
CAS:N,N-Dimethylacetamide (DMAc) is a drug excipient with anti-inflammatory activity, acting through the inhibition of the NF-κB signaling pathway.Fórmula:C4H9NOPureza:99.13%Cor e Forma:Colourless LiquidPeso molecular:87.12Hentriacontane
CAS:Hentriacontane is a natural product with various pharmacological effects including anti-inflammatory, antitumor, and antimicrobial activities.Fórmula:C31H64Pureza:95.85%Cor e Forma:SolidPeso molecular:436.84NBD peptide
CAS:NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.Fórmula:C62H88N14O20Cor e Forma:SolidPeso molecular:1349.44Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:99.13% - 99.8%Cor e Forma:SolidPeso molecular:947.15Ref: TM-T2878
1mg39,00€5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg455,00€500mg998,00€1mL*10mM (DMSO)131,00€IRAK4-IN-24
IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability.Fórmula:C19H19N5O3Pureza:98%Cor e Forma:SolidPeso molecular:365.39Embelin
CAS:Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Fórmula:C17H26O4Pureza:97.07% - 99.88%Cor e Forma:SolidPeso molecular:294.39RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Fórmula:C27H28N4O3Cor e Forma:SolidPeso molecular:456.54Schisantherin A
CAS:Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.Fórmula:C30H32O9Pureza:98% - 99.96%Cor e Forma:SolidPeso molecular:536.57Cudraflavone B
CAS:Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45Sabialimon P
CAS:Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.Fórmula:C31H50O4Cor e Forma:SolidPeso molecular:486.73BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.58Ref: TM-T10477
1mg172,00€5mg354,00€10mg567,00€25mg905,00€50mg1.225,00€100mg1.644,00€1mL*10mM (DMSO)430,00€SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Cor e Forma:Odour SolidGLPG2534
CAS:GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.Fórmula:C21H24N6O4Pureza:98.89% - 99.61%Cor e Forma:SolidPeso molecular:424.45GSK3145095
CAS:GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.Fórmula:C20H17F2N5O2Pureza:99.50%Cor e Forma:SolidPeso molecular:397.38Ref: TM-T15437
1mg96,00€5mg246,00€10mg344,00€25mg553,00€50mg727,00€100mg938,00€1mL*10mM (DMSO)240,00€SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Fórmula:C9H8N2OS2Pureza:100% - 99.88%Cor e Forma:SolidPeso molecular:224.3Ginsenoside Rg5
CAS:Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Fórmula:C42H70O12Pureza:98% - 98.07%Cor e Forma:SolidPeso molecular:767Ref: TM-T6S1487
1mg113,00€5mg265,00€10mg426,00€25mg702,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)360,00€Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Fórmula:C7H5NaO3Pureza:99.36% - 99.77%Cor e Forma:White Solid AmorphousPeso molecular:160.11Aconine
CAS:1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.Fórmula:C25H41NO9Pureza:99.43% - 99.61%Cor e Forma:SolidPeso molecular:499.59AS-2444697
CAS:AS-2444697, an IRAK-4 inhibitor (C50=21 nM), offers renal protection via anti-inflammatory effects on human and rat IRAK-4.Fórmula:C19H21ClN6O4Pureza:97.43%Cor e Forma:SolidPeso molecular:432.86Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Cor e Forma:White Crystal PowderPeso molecular:270.798WEHI-345
CAS:WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.Fórmula:C22H23N7OPureza:100%Cor e Forma:SolidPeso molecular:401.46Cpd27
CAS:Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.Fórmula:C20H13F4N5O2Pureza:98.89%Cor e Forma:SolidPeso molecular:431.34TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Fórmula:C28H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:498.53Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Cor e Forma:White Crystalline SolidPeso molecular:350.45IRAK inhibitor 2
CAS:IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.Fórmula:C17H14N4O2Pureza:97.62% - 99.26%Cor e Forma:SolidPeso molecular:306.32Ref: TM-T7368
1mg86,00€5mg180,00€10mg259,00€25mg455,00€50mg655,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)188,00€LTβR-IN-1
CAS:LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.Fórmula:C18H16N4O2Pureza:99.09%Cor e Forma:SolidPeso molecular:320.35Ref: TM-T11886
1mg35,00€5mg80,00€10mg116,00€25mg220,00€50mg328,00€100mg469,00€500mg938,00€1mL*10mM (DMSO)87,00€yangonin
CAS:Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.Fórmula:C15H14O4Pureza:98.82% - 99.55%Cor e Forma:Pale Yellow PowderPeso molecular:258.27Ref: TM-T3S0738
1mg70,00€5mg135,00€10mg207,00€25mg349,00€50mg515,00€100mg735,00€1mL*10mM (DMSO)177,00€Sulfasalazine
CAS:Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Fórmula:C18H14N4O5SPureza:98.00% - 99.28%Cor e Forma:Minute Brownish-Yellow CrystalsPeso molecular:398.39Tryptanthrin
CAS:Tryptanthrin is a natural DNA gyrase inhibitor.Fórmula:C15H8N2O2Pureza:99.64% - 99.94%Cor e Forma:SolidPeso molecular:248.24GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Fórmula:C28H19FN2O4Pureza:99.72%Cor e Forma:SolidPeso molecular:466.46Ref: TM-T25465
2mg38,00€5mg58,00€10mg92,00€25mg170,00€50mg259,00€100mg378,00€200mg548,00€1mL*10mM (DMSO)60,00€Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Fórmula:C23H24O6Pureza:96.05%Cor e Forma:SolidPeso molecular:396.43Ref: TM-T19853
5mg50,00€10mg81,00€25mg140,00€50mg239,00€100mg349,00€200mg497,00€1mL*10mM (DMSO)56,00€BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:98.74% - 99.74%Cor e Forma:SolidPeso molecular:255.32Licochalcone D
CAS:Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Fórmula:C21H22O5Pureza:99.03% - 99.9%Cor e Forma:SolidPeso molecular:354.4SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64% - 99.64%Cor e Forma:SolidPeso molecular:328.69Ref: TM-T22115
5mg47,00€10mg74,00€25mg135,00€50mg188,00€100mg283,00€200mg411,00€1mL*10mM (DMSO)50,00€Picroside II
CAS:Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.Fórmula:C23H28O13Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:512.46NF-κB-IN-13
CAS:NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1Fórmula:C20H20O5Pureza:98%Cor e Forma:SolidPeso molecular:340.37
