NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
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INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3Ref: TM-T5209
2mg38,00€5mg56,00€10mg84,00€25mg120,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Fórmula:C22H21ClF2N4OCor e Forma:SolidPeso molecular:430.88SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Fórmula:C131H234N36O31SPureza:99.86%Cor e Forma:SolidPeso molecular:2841.55Asperulosidic acid
CAS:Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Fórmula:C18H24O12Pureza:99.47%Cor e Forma:SolidPeso molecular:432.38SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Fórmula:C129H230N36O29S·XCF3COOHCor e Forma:SolidPeso molecular:2781.5 (free base)CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Fórmula:C23H17Cl2NO4Pureza:98.17%Cor e Forma:SolidPeso molecular:442.29Ref: TM-T9582
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)219,00€Tectochrysin
CAS:Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Fórmula:C16H12O4Pureza:99.26%Cor e Forma:SolidPeso molecular:268.26RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Fórmula:C24H16N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:456.54IRAK4-IN-10
CAS:IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Fórmula:C22H24N8Pureza:99.76%Cor e Forma:SolidPeso molecular:400.48Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:1091.24Fibrinogen
CAS:Fibrinogen is a heterodimeric protein that can be cleaved by thrombin.Cor e Forma:SolidHesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Fórmula:C29H36O15Pureza:99.53%Cor e Forma:Yellow PowderPeso molecular:624.59(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Fórmula:C16H16N6OPureza:98.44%Cor e Forma:SolidPeso molecular:308.34Ref: TM-T8692
1mg73,00€5mg124,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)137,00€(−)-N-Hydroxyapiosporamide
CAS:(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo.Fórmula:C24H31NO7Pureza:98%Cor e Forma:SolidPeso molecular:445.51Iron sucrose
CAS:Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Fórmula:C18H24Fe2O24Pureza:98%Cor e Forma:SolidPeso molecular:736.1MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Fórmula:C26H37ClN6O2Pureza:98.19%Cor e Forma:SolidPeso molecular:501.07ALPK1-IN-3
CAS:ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-inducedFórmula:C20H16F2N4OSPureza:98%Cor e Forma:SolidPeso molecular:398.43Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Fórmula:C54H92O23Pureza:99.12% - 99.76%Cor e Forma:SolidPeso molecular:1109.29Eurycomalactone
CAS:Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Fórmula:C19H24O6Pureza:98.98% - 99.87%Cor e Forma:SolidPeso molecular:348.39Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Fórmula:C25H24O6Pureza:98.68% - 99.8%Cor e Forma:SolidPeso molecular:420.45Sodium Aescinate
CAS:Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Fórmula:C54H83NaO23Pureza:95.17%Cor e Forma:SolidPeso molecular:1123.21Dehydrodiisoeugenol
CAS:Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Fórmula:C20H22O4Pureza:99.97%Cor e Forma:SolidPeso molecular:326.39Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:SolidPeso molecular:344.36EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Fórmula:C18H18ClMnN2O4Pureza:98.39%Cor e Forma:SolidPeso molecular:416.74Ref: TM-T6495
10mg35,00€25mg66,00€50mg104,00€100mg160,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)47,00€GSK-872
CAS:GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Fórmula:C19H17N3O2S2Pureza:99.3%Cor e Forma:SolidPeso molecular:383.49Ref: TM-T4074
1mg38,00€5mg79,00€10mg119,00€25mg188,00€50mg321,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)86,00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Fórmula:C22H28N2O14Pureza:98%Cor e Forma:SolidPeso molecular:544.46Necrostatin-34
CAS:Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFórmula:C18H16N4O2S2Pureza:98.66% - 98.80%Cor e Forma:SolidPeso molecular:384.48Ref: TM-T9095
1mg52,00€5mg116,00€10mg170,00€25mg305,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)135,00€HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Fórmula:C17H13NaO4Pureza:98.83%Cor e Forma:SoildPeso molecular:304.27Mangiferin
CAS:Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Fórmula:C19H18O11Pureza:96.74% - 98.30%Cor e Forma:Light Yellow PowderPeso molecular:422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFórmula:C24H21Cl2NO3Pureza:98%Cor e Forma:SolidPeso molecular:442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Fórmula:C28H28N2O6SCor e Forma:SolidPeso molecular:520.6GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Fórmula:C22H20O8Cor e Forma:SolidPeso molecular:412.39Oxaprozin
CAS:Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Fórmula:C18H15NO3Pureza:98.53%Cor e Forma:SolidPeso molecular:293.32Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Fórmula:C19H18FN3O·H3PO4Pureza:99.1%Cor e Forma:SolidPeso molecular:421.36Ref: TM-T6127
1mg38,00€2mg49,00€5mg79,00€10mg115,00€25mg188,00€50mg248,00€100mg393,00€200mg585,00€1mL*10mM (DMSO)79,00€Dehydroevodiamine
CAS:Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFórmula:C19H15N3OPureza:99.54%Cor e Forma:SolidPeso molecular:301.34GSK583
CAS:GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Fórmula:C20H19FN4O2SPureza:98.68% - 99.06%Cor e Forma:SolidPeso molecular:398.45Ref: TM-T3537
1mg50,00€2mg71,00€5mg116,00€10mg190,00€25mg319,00€50mg465,00€100mg690,00€500mg1.444,00€1mL*10mM (DMSO)116,00€Moslosooflavone
CAS:Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Fórmula:C17H14O5Pureza:98% - 99.78%Cor e Forma:SolidPeso molecular:298.29IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Fórmula:C12H11N3O2SPureza:100%Cor e Forma:SolidPeso molecular:261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Astilbin
CAS:Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Fórmula:C21H22O11Pureza:97% - 99.76%Cor e Forma:White PowderPeso molecular:450.39Ref: TM-T2794
5mg52,00€10mg77,00€25mg140,00€50mg224,00€100mg334,00€200mg477,00€500mg778,00€1mL*10mM (DMSO)51,00€Rucaparib monocamsylate
CAS:Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Fórmula:C29H34FN3O5SPureza:99.82%Cor e Forma:SolidPeso molecular:555.66Ref: TM-T16807
5mg60,00€10mg96,00€25mg160,00€50mg235,00€100mg354,00€200mg522,00€1mL*10mM (DMSO)74,00€Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Fórmula:C20H18O11Pureza:97.02% - 99.94%Cor e Forma:White PowderPeso molecular:434.35Ref: TM-T6S0117
1mg58,00€5mg97,00€10mg160,00€25mg283,00€50mg418,00€100mg615,00€200mg878,00€1mL*10mM (DMSO)111,00€Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Fórmula:C19H24ClNO4Pureza:99.43%Cor e Forma:SolidPeso molecular:365.851(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Fórmula:C13H18O2Pureza:99.47%Cor e Forma:SolidPeso molecular:206.28Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFórmula:C27H30O15Pureza:96.96% - 98.17%Cor e Forma:SolidPeso molecular:594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Fórmula:C37H42Cl2N2O6Pureza:95% - 99.38%Cor e Forma:SolidPeso molecular:681.65Dauricine
CAS:1.Fórmula:C38H44N2O6Pureza:99.04% - 99.38%Cor e Forma:White PowderPeso molecular:624.77JH-X-119-01
CAS:JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.Fórmula:C25H20N6O3Pureza:97.1%Cor e Forma:SolidPeso molecular:452.46Ref: TM-T9203
1mg66,00€2mg96,00€5mg144,00€10mg210,00€25mg376,00€50mg562,00€100mg780,00€1mL*10mM (DMSO)159,00€Diethylmaleate
CAS:Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.Fórmula:C8H12O4Pureza:98%Cor e Forma:Colourless LiquidPeso molecular:172.1818α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Fórmula:C30H46O4Pureza:98.54% - 99.68%Cor e Forma:SolidPeso molecular:470.68Tenuigenin
CAS:Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Fórmula:C30H45ClO6Pureza:98.9% - 99.53%Cor e Forma:SolidPeso molecular:537.13Ref: TM-T3907
2mg37,00€5mg52,00€10mg77,00€25mg111,00€50mg160,00€100mg227,00€200mg335,00€1mL*10mM (DMSO)66,00€RIPK1-IN-7
CAS:RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.Fórmula:C25H22F3N5O2Pureza:98.02% - 98.18%Cor e Forma:SolidPeso molecular:481.47Ref: TM-T12731
1mg92,00€5mg216,00€10mg329,00€25mg512,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)233,00€Sciadopitysin
CAS:Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Fórmula:C33H24O10Pureza:98.14% - 99.17%Cor e Forma:SolidPeso molecular:580.54Ref: TM-T5S2129
1mg52,00€5mg95,00€10mg162,00€25mg304,00€50mg455,00€100mg653,00€500mg1.349,00€1mL*10mM (DMSO)130,00€Sarsasapogenin
CAS:Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Fórmula:C27H44O3Pureza:90% - 99.73%Cor e Forma:White Or Off-Withe PowderPeso molecular:416.64MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€DRI-C21045
CAS:Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Fórmula:C32H24N2O7SPureza:98.10%Cor e Forma:SolidPeso molecular:580.61IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Fórmula:C15H9N3OPureza:97.92% - 99.05%Cor e Forma:SolidPeso molecular:247.25Ref: TM-T3627
5mg47,00€10mg52,00€25mg96,00€50mg169,00€100mg304,00€200mg454,00€500mg733,00€1mL*10mM (DMSO)50,00€NF-κΒ activator 1
CAS:NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Fórmula:C16H11FN2O2SPureza:98.85%Cor e Forma:SolidPeso molecular:314.33Ref: TM-T39965
1mg95,00€5mg202,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€1mL*10mM (DMSO)224,00€Dehydrocostus Lactone
CAS:Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Fórmula:C15H18O2Pureza:99.86% - 99.98%Cor e Forma:SolidPeso molecular:230.3Theophylline monohydrate
CAS:Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFórmula:C7H8N4O2·H2OPureza:99.78%Cor e Forma:SolidPeso molecular:198.18Chelidonic acid
CAS:Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Fórmula:C7H4O6Pureza:99.03%Cor e Forma:SolidPeso molecular:184.1Cyclo(his-pro)
CAS:Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.Fórmula:C11H14N4O2Pureza:99.87%Cor e Forma:SolidPeso molecular:234.25Tripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Fórmula:C29H30N4O5Pureza:98%Cor e Forma:SolidPeso molecular:514.57Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.Fórmula:C20H21F3N4O4SPureza:98.48%Cor e Forma:SolidPeso molecular:470.47Ref: TM-T37076
1mg43,00€5mg96,00€10mg135,00€25mg220,00€50mg323,00€100mg450,00€500mgA consultar1mL*10mM (DMSO)96,00€NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Fórmula:C19H18O5Pureza:98%Cor e Forma:SolidPeso molecular:326.34Kamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Fórmula:C20H30O5Pureza:98.05%Cor e Forma:SolidPeso molecular:350.45NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Fórmula:C20H22N4O3Cor e Forma:SolidPeso molecular:366.41CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).Fórmula:C19H18N3O2PSPureza:99.41%Cor e Forma:SolidPeso molecular:383.4Prostratin
CAS:Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.Fórmula:C22H30O6Pureza:98%Cor e Forma:White To Off-White PowderPeso molecular:390.47Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFórmula:C21H18O11Pureza:90.08% - 99.25%Cor e Forma:Yellow PowderPeso molecular:446.36CAFESTOL
CAS:Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Fórmula:C20H28O3Pureza:97.06% - 99.08%Cor e Forma:SolidPeso molecular:316.43NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Fórmula:C13H8F2INO2Pureza:99.64%Cor e Forma:SolidPeso molecular:375.11Cyclo(L-Pro-L-Val)
CAS:Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.Fórmula:C10H16N2O2Pureza:98.18%Cor e Forma:SolidPeso molecular:196.25CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Fórmula:C33H45F3N2O3Pureza:95.61% - 99.59%Cor e Forma:SolidPeso molecular:574.72Ref: TM-T13604
1mg70,00€2mg92,00€5mg153,00€10mg255,00€25mg512,00€50mg738,00€100mg1.035,00€500mg2.062,00€1mL*10mM (DMSO)187,00€Rucaparib
CAS:Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Fórmula:C19H18FN3OPureza:98.37% - 99.80%Cor e Forma:SolidPeso molecular:323.36Ref: TM-T4463
2mg48,00€5mg73,00€10mg115,00€25mg173,00€50mg235,00€100mg364,00€200mg540,00€500mg869,00€1mL*10mM (DMSO)81,00€SC75741
CAS:SC75741 is a potent P65 inhibitor with IC50 of 200 nMFórmula:C29H23N7O2S2Pureza:99.44% - 99.82%Cor e Forma:SolidPeso molecular:565.67Edecesertib
CAS:Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Fórmula:C22H22FN7O2Pureza:98.84%Cor e Forma:SolidPeso molecular:435.45ANTHRAQUINONE-2-CARBOXYLIC ACID
CAS:Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role ofFórmula:C15H8O4Pureza:99.08% - 99.83%Cor e Forma:SolidPeso molecular:252.22Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Fórmula:C29H31NO7Pureza:95.32% - 98.46%Cor e Forma:SolidPeso molecular:505.56Muscone
CAS:Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Fórmula:C16H30OPureza:99.28%Cor e Forma:Colourless Liquid LiquidPeso molecular:238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Fórmula:C27H37N7O2Pureza:99.91%Cor e Forma:SolidPeso molecular:491.63Zingerone
CAS:Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Fórmula:C11H14O3Pureza:99.38% - 99.85%Cor e Forma:Clear Slightly Yellow LiquidPeso molecular:194.23PROTAC IRAK4 degrader-8
CAS:PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Fórmula:C43H50ClF2N11O5Pureza:98%Cor e Forma:SolidPeso molecular:874.38WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Fórmula:C17H13F3N2O2Pureza:98.63% - 98.64%Cor e Forma:SolidPeso molecular:334.29Ref: TM-T8981
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg329,00€100mg475,00€200mg655,00€1mL*10mM (DMSO)94,00€Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Fórmula:C23H17N3OS3Pureza:98.02% - 98.31%Cor e Forma:SolidPeso molecular:447.6Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Fórmula:C23H25N2·C2HO4C2H2O4Cor e Forma:Dark Green Crystals With A Metallic LusterPeso molecular:463.51IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.56% - 99.71%Cor e Forma:SolidPeso molecular:383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€RIP2 Kinase Inhibitor 3
CAS:RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Fórmula:C19H24N4O3SPureza:98.28% - 98.35%Cor e Forma:SolidPeso molecular:388.48Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Fórmula:C30H32O13Pureza:97.64% - 98.7%Cor e Forma:SolidPeso molecular:600.57Ref: TM-T4S1658
1mg127,00€5mg298,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)378,00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Fórmula:C20H19N5O2SPureza:98%Cor e Forma:SolidPeso molecular:393.46IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Fórmula:C22H25F3N4O3Pureza:97.32%Cor e Forma:SolidPeso molecular:450.45Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Fórmula:C24H32O8Pureza:99.84% - 99.92%Cor e Forma:SolidPeso molecular:448.51Ref: TM-T10383
1mg88,00€5mg202,00€10mg303,00€25mg509,00€50mg725,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)198,00€BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€Velutin
CAS:Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFórmula:C17H14O6Pureza:99.69%Cor e Forma:SolidPeso molecular:314.29AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Cor e Forma:SolidPeso molecular:485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PROTAC IRAK4 degrader-12
CAS:PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Fórmula:C46H50ClF2N11O6Cor e Forma:SolidPeso molecular:926.41BI-69A11
CAS:BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Fórmula:C25H16ClN3O2Pureza:96.97%Cor e Forma:SolidPeso molecular:425.87Ref: TM-T25150
1mg46,00€2mg57,00€5mg82,00€10mg96,00€25mg180,00€50mg259,00€100mg369,00€1mL*10mM (DMSO)93,00€
