IκB/IKK
O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.
Produtos da "IκB/IKK"
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SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Fórmula:C9H8N2OS2Pureza:100% - 99.88%Cor e Forma:SolidPeso molecular:224.3Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Cor e Forma:White Crystalline SolidPeso molecular:350.45BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Fórmula:C14H17N5Pureza:98.74% - 99.74%Cor e Forma:SolidPeso molecular:255.32INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3Ref: TM-T5209
2mg38,00€5mg56,00€10mg84,00€25mg120,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Fórmula:C26H37ClN6O2Pureza:98.19%Cor e Forma:SolidPeso molecular:501.07Selinidin
CAS:Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Fórmula:C19H20O5Pureza:98%Cor e Forma:SolidPeso molecular:328.364ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Fórmula:C21H25ClN4O2Pureza:100%Cor e Forma:SolidPeso molecular:400.9Ref: TM-T10237
1mg66,00€5mg144,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€1mL*10mM (DMSO)159,00€IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Fórmula:C12H11N3O2SPureza:100%Cor e Forma:SolidPeso molecular:261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Cudraflavone B
CAS:Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.58Ref: TM-T10477
1mg172,00€5mg354,00€10mg567,00€25mg905,00€50mg1.225,00€100mg1.644,00€1mL*10mM (DMSO)430,00€Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Fórmula:C28H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:498.53Dehydrocostus Lactone
CAS:Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Fórmula:C15H18O2Pureza:99.86% - 99.98%Cor e Forma:SolidPeso molecular:230.3GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Fórmula:C28H19FN2O4Pureza:99.72%Cor e Forma:SolidPeso molecular:466.46Ref: TM-T25465
2mg38,00€5mg58,00€10mg92,00€25mg170,00€50mg259,00€100mg378,00€200mg548,00€1mL*10mM (DMSO)60,00€CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Fórmula:C27H37N7O2Pureza:99.91%Cor e Forma:SolidPeso molecular:491.63MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€Armepavine
CAS:Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.Fórmula:C19H23NO3Pureza:95.00%Cor e Forma:SolidPeso molecular:313.39IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.56% - 99.71%Cor e Forma:SolidPeso molecular:383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€
