CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Produtos da "CCR"
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71 produtos desta categoria.
AZD-5672
CAS:AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.Fórmula:C32H38F2N2O5S2Pureza:95.58%Cor e Forma:SolidPeso molecular:632.78Ref: TM-T30260
1mg202,00€5mg459,00€10mg643,00€25mg938,00€50mg1.311,00€100mg1.786,00€1mL*10mM (DMSO)560,00€C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Fórmula:C27H43Cl2N5O2Pureza:98.51%Cor e Forma:SolidPeso molecular:540.57ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Fórmula:C21H28N2O3Pureza:99.43%Cor e Forma:SolidPeso molecular:356.46CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Fórmula:C21H23ClN4O3SPureza:98.40% - 99.26%Cor e Forma:SolidPeso molecular:446.95Maraviroc
CAS:Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s-MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Fórmula:C29H41F2N5OPureza:100% - 99.55%Cor e Forma:Brown SolidPeso molecular:513.67Ref: TM-T6016
5mg51,00€10mg95,00€25mg160,00€50mg273,00€100mg492,00€200mg633,00€500mg998,00€1mL*10mM (DMSO)59,00€7,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:SolidPeso molecular:254.24CCR1 antagonist 8
CAS:CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).Fórmula:C22H18FN5O3SCor e Forma:SolidPeso molecular:451.47J-113863
CAS:J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Fórmula:C30H37Cl2IN2O2Pureza:98%Cor e Forma:SolidPeso molecular:655.44Ref: TM-T11699
1mg59,00€2mg87,00€5mg126,00€10mg169,00€25mg304,00€50mg527,00€100mg758,00€1mL*10mM (DMSO)180,00€AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Fórmula:C27H32Cl2N2O7Pureza:99.01%Cor e Forma:SolidPeso molecular:567.46R243
CAS:R243 is CCR8 signaling and chemotaxis inhibitor.Fórmula:C21H27NO4Pureza:97.86%Cor e Forma:SolidPeso molecular:357.44Ref: TM-T24700
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg220,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)95,00€YM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Fórmula:C32H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:516.59CCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Fórmula:C21H24ClN5O3SPureza:98%Cor e Forma:SolidPeso molecular:461.96BMS-813160
CAS:BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Fórmula:C25H40N8O2Pureza:99.66% - 99.78%Cor e Forma:SolidPeso molecular:484.64Ref: TM-T4584
1mg63,00€5mg137,00€10mg187,00€25mg341,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)145,00€Cenicriviroc
CAS:Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Fórmula:C41H52N4O4SPureza:97.87%Cor e Forma:SolidPeso molecular:696.94Ref: TM-TQ0297
1mg69,00€5mg149,00€10mg235,00€25mg470,00€50mg610,00€100mg793,00€200mg1.064,00€1mL*10mM (DMSO)221,00€BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Fórmula:C28H34F3N5O4SPureza:99.05%Cor e Forma:SolidPeso molecular:593.66Ref: TM-T14688
1mg58,00€5mg116,00€10mg183,00€25mg368,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)156,00€CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Fórmula:C14H12N2SPureza:99.53%Cor e Forma:SolidPeso molecular:240.32MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Fórmula:C30H31ClN2O4Pureza:98.62%Cor e Forma:SolidPeso molecular:519.03IPG7236
CAS:IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFórmula:C23H31N3O3SPureza:98%Cor e Forma:SolidPeso molecular:429.58Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:Odour LiquidNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidLanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidINCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98.00% - 98.2%Cor e Forma:SolidPeso molecular:577.59Ref: TM-TQ0103
1mg70,00€5mg153,00€10mg243,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)188,00€PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Cor e Forma:SolidPeso molecular:568.59BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Fórmula:C23H27N5O3SPureza:99.83%Cor e Forma:SolidPeso molecular:453.56CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Fórmula:C20H13ClF3N5O3SPureza:97.58% - 99.95%Cor e Forma:SolidPeso molecular:495.86Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Fórmula:C22H21ClN2O4SPureza:99.23%Cor e Forma:SolidPeso molecular:444.93Ref: TM-T17225
1mg105,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)363,00€CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:97.33%Cor e Forma:SolidPeso molecular:495.59Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Fórmula:C32H42F3N5O6Pureza:97.51% - 98.16%Cor e Forma:SolidPeso molecular:649.7RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Cor e Forma:SolidPeso molecular:383.27MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Fórmula:C32H32ClF3N2O6Pureza:98.62%Cor e Forma:SolidPeso molecular:633.05SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Fórmula:C27H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:456.54SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Fórmula:C18H18N2O5Pureza:99.59%Cor e Forma:SolidPeso molecular:342.35AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Fórmula:C11H9Cl2N3O3SPureza:99.80% - 99.92%Cor e Forma:SolidPeso molecular:334.18Ref: TM-T4300
1mg35,00€5mg70,00€10mg111,00€25mg230,00€50mg354,00€100mg530,00€500mg1.121,00€1mL*10mM (DMSO)78,00€CCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.Fórmula:C24H23F3N4O3SPureza:98.91%Cor e Forma:SolidPeso molecular:504.52Ref: TM-T10715
1mg116,00€5mg283,00€10mg424,00€25mg682,00€50mg934,00€100mg1.301,00€500mg2.612,00€1mL*10mM (DMSO)311,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Fórmula:C33H39ClN2O2Pureza:99.21%Cor e Forma:SolidPeso molecular:531.13CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Fórmula:C21H24ClFN4O3Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:434.89Ref: TM-T2375
1mg38,00€5mg90,00€10mg124,00€25mg212,00€50mg329,00€100mg515,00€200mg782,00€1mL*10mM (DMSO)90,00€DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Fórmula:C35H56N10O15Pureza:100%Cor e Forma:SolidPeso molecular:856.88Bindarit
CAS:Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.Fórmula:C19H20N2O3Pureza:98.35% - 98.71%Cor e Forma:SolidPeso molecular:324.37Ref: TM-T6413
1mg57,00€5mg123,00€10mg187,00€25mg315,00€50mg472,00€100mg677,00€500mg1.388,00€1mL*10mM (DMSO)137,00€CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Fórmula:C19H21Cl2N3O4S2Pureza:99.85%Cor e Forma:SolidPeso molecular:490.42Ref: TM-T10156
1mg92,00€5mg188,00€10mg305,00€25mg489,00€50mg655,00€100mg883,00€1mL*10mM (DMSO)224,00€CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Fórmula:C22H22ClN7O2Pureza:99% - 99.28%Cor e Forma:SolidPeso molecular:451.91RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Fórmula:C21H22ClF3N2O2Pureza:98.95%Cor e Forma:SolidPeso molecular:426.86MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Cor e Forma:Odour SolidCCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Fórmula:C22H29NO3Cor e Forma:SolidPeso molecular:355.47ML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Fórmula:C27H32N4O4SPureza:99.91%Cor e Forma:SolidPeso molecular:508.63MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Fórmula:C28H40F3N3O7Pureza:98.62%Cor e Forma:SolidPeso molecular:587.63CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Fórmula:C22H25F3N4O3SPureza:98.79%Cor e Forma:SolidPeso molecular:482.52GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Fórmula:C24H25ClN4O5S2Pureza:99.78%Cor e Forma:SolidPeso molecular:549.06Ref: TM-T11481
1mg38,00€5mg84,00€10mg125,00€25mg259,00€50mg375,00€100mg545,00€500mgA consultar1mL*10mM (DMSO)93,00€Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.71CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFórmula:C21H21ClF3N3O2Pureza:99.63%Cor e Forma:SolidPeso molecular:439.86Ref: TM-T13114
1mg52,00€5mg120,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€1mL*10mM (DMSO)133,00€AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Fórmula:C26H34N4O2Pureza:97.12%Cor e Forma:SolidPeso molecular:434.57Ref: TM-T10425
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)182,00€RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.49% - 98.64%Cor e Forma:SolidPeso molecular:417.5CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Fórmula:C17H25FN2O2Pureza:100%Cor e Forma:SolidPeso molecular:308.39Ref: TM-T10712
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)170,00€CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Fórmula:C35H47FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:574.77Cenicriviroc Mesylate
CAS:Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.Fórmula:C42H56N4O7S2Pureza:98%Cor e Forma:SolidPeso molecular:793.05PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Fórmula:C25H36F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.58AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFórmula:C20H29ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:425.93C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Fórmula:C27H41N5O2Pureza:100.00% - 99.74%Cor e Forma:SolidPeso molecular:467.65Ref: TM-T21870
1mg51,00€2mg71,00€5mg96,00€10mg153,00€25mg303,00€50mg469,00€100mg655,00€1mL*10mM (DMSO)96,00€Azirkitug
Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidRS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Fórmula:C21H21F3N2O2Pureza:97.64%Cor e Forma:SolidPeso molecular:390.4CCR2-RA-[R]
CAS:CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).Fórmula:C18H19ClFNO3Pureza:99.70%Cor e Forma:SolidPeso molecular:351.8CCR6 antagonist 1
CAS:CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.Fórmula:C17H12F3NO2Pureza:99.89%Cor e Forma:SoildPeso molecular:319.28Ref: TM-T60145
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg227,00€50mg329,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Fórmula:C21H18N2O5Pureza:99.11%Cor e Forma:SolidPeso molecular:378.38BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Fórmula:C23H36ClN3O4Pureza:99.05%Cor e Forma:SolidPeso molecular:454Ref: TM-T26861
1mg160,00€5mg338,00€10mg512,00€25mg812,00€50mg1.093,00€100mg1.473,00€1mL*10mM (DMSO)376,00€CCR1 antagonist 9
CAS:CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).Fórmula:C20H16FN5O3SCor e Forma:SolidPeso molecular:425.44GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Fórmula:C21H24Cl2N4O3Cor e Forma:SolidPeso molecular:451.35Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidDenrakibart
Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.Cor e Forma:Odour LiquidINCB 3284
CAS:INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Fórmula:C26H31F3N4O4Pureza:99.55% - 99.82%Cor e Forma:SolidPeso molecular:520.54
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