TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Produtos da "TLR"
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63 produtos desta categoria.
MD2-TLR4-IN-1
CAS:MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.Fórmula:C22H14Cl2N4OPureza:97.74%Cor e Forma:SolidPeso molecular:421.28Ref: TM-T7672
1mg62,00€5mg135,00€10mg212,00€25mg363,00€50mg510,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)149,00€TLR3-IN-1
CAS:TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.Fórmula:C18H13ClFNO3SPureza:98.56%Cor e Forma:SolidPeso molecular:377.82Ref: TM-T22698
1mg52,00€2mg74,00€5mg114,00€10mg187,00€25mg398,00€50mg593,00€100mg845,00€500mg1.700,00€1mL*10mM (DMSO)126,00€MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate
CAS:MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.Fórmula:C52H72N12O11Pureza:97.70%Cor e Forma:SolidPeso molecular:1041.2LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Fórmula:C29H32F2N3O7PPureza:98%Cor e Forma:SolidPeso molecular:603.55Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Fórmula:C33H40O19Pureza:98.78% - 99.13%Cor e Forma:SolidPeso molecular:740.66Polyinosinic-polycytidylic acid
CAS:Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts as the most potent IFN inducer.Fórmula:(C10H13N4O8P)x·(C9H14N3O8P)xPureza:90%Cor e Forma:SolidPeso molecular:671.4CL264
CAS:CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.Fórmula:C19H23N7O4Pureza:97.14%Cor e Forma:SolidPeso molecular:413.43Ref: TM-T10833
1mg51,00€5mg116,00€10mg192,00€25mg304,00€50mg420,00€100mg560,00€200mg755,00€1mL*10mM (DMSO)128,00€3M-011
CAS:3M-011: potent TLR7/8 agonist, cytokine inducer, enhances radiotherapy, fights H3N2, and has anti-tumor effects.Fórmula:C18H25N5O3SPureza:98%Cor e Forma:SolidPeso molecular:391.49IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Fórmula:C35H71NO5Pureza:98.17%Cor e Forma:SolidPeso molecular:585.94Bropirimine
CAS:Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.Fórmula:C10H8BrN3OPureza:99.01%Cor e Forma:SolidPeso molecular:266.09TL8-506
CAS:TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.Fórmula:C20H17N3O2Pureza:95%Cor e Forma:SolidPeso molecular:331.37MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.Fórmula:C54H73F3N12O13Pureza:99.67%Cor e Forma:SolidPeso molecular:1155.22Ref: TM-T74468L
1mg201,00€5mg497,00€10mg701,00€25mg1.094,00€50mg1.508,00€100mg1.931,00€200mg2.637,00€BBIQ
CAS:BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1Fórmula:C21H22N4Pureza:98.02%Cor e Forma:SolidPeso molecular:330.43Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Fórmula:C28H34N4O2Pureza:97.43% - 99.27%Cor e Forma:SolidPeso molecular:458.6TLR7 agonist 3
CAS:TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.Fórmula:C18H24N4OPureza:99.27%Cor e Forma:SolidPeso molecular:312.41Ref: TM-T38614
1mg115,00€5mg274,00€10mg455,00€25mg748,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)303,00€VB 201
CAS:VB 201 is a small molecule of oxidized phospholipids with anti-inflammatory activity that can be used to study atherosclerosis.Fórmula:C29H60NO8PPureza:100%Cor e Forma:SolidPeso molecular:581.76E6446 dihydrochloride
CAS:E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.Fórmula:C27H37Cl2N3O3Pureza:98.44%Cor e Forma:SolidPeso molecular:522.51Ref: TM-T4068
1mg107,00€2mg169,00€5mg304,00€10mg376,00€25mg628,00€50mg895,00€100mg1.216,00€200mg1.634,00€1V209
CAS:1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.Fórmula:C16H17N5O5Pureza:99.61%Cor e Forma:SolidPeso molecular:359.34Ref: TM-T8316
1mg38,00€5mg79,00€10mg126,00€25mg271,00€50mg395,00€100mg560,00€200mg797,00€1mL*10mM (DMSO)87,00€CU-CPT9b
CAS:CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).Fórmula:C16H13NO2Pureza:98.10%Cor e Forma:SolidPeso molecular:251.28Chloranil
CAS:Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Fórmula:C6Cl4O2Pureza:99.38%Cor e Forma:SolidPeso molecular:245.88CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Fórmula:C19H22O7Pureza:98.66%Cor e Forma:SolidPeso molecular:362.37Ref: TM-T15020
1mg52,00€2mg70,00€5mg99,00€10mg168,00€25mg313,00€50mg469,00€100mg682,00€200mg938,00€1mL*10mM (DMSO)114,00€BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Fórmula:C23H29N3Pureza:99.85%Cor e Forma:SoildPeso molecular:347.5SM-324405
CAS:SM-324405 is an agonist of TLR7.Fórmula:C19H23N5O4Pureza:97.83%Cor e Forma:SolidPeso molecular:385.42Ref: TM-T7860
1mg37,00€5mg78,00€10mg113,00€25mg202,00€50mg324,00€100mg462,00€200mg645,00€1mL*10mM (DMSO)87,00€AXC-715 trihydrochloride
CAS:AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.Fórmula:C18H28Cl3N5Pureza:99.74%Cor e Forma:SolidPeso molecular:420.81Gardiquimod
CAS:Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.Fórmula:C17H23N5OPureza:98.02% - 99.47%Cor e Forma:SolidPeso molecular:313.4CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Fórmula:C27H24N2O8Pureza:98.49%Cor e Forma:SolidPeso molecular:504.49Cholesterol oxidase
CAS:Cholesterol oxidase catalyzes the oxidation and isomerization of cholesterol. ChOx competitively inhibits TLR2 enhance ROS production by macrophages.Cor e Forma:SolidE6446
CAS:E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling.Fórmula:C27H35N3O3Pureza:98.72%Cor e Forma:SolidPeso molecular:449.59Rabeximod
CAS:Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.Fórmula:C22H24ClN5OPureza:100%Cor e Forma:SolidPeso molecular:409.91Tomaralimab
CAS:Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).Pureza:> 95% - SDS-PAGE:95% SEC-HPLC:99.99%Cor e Forma:LiquidPeso molecular:145.32 kDaTLR7/8 agonist 1 dihydrochloride
CAS:TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Fórmula:C22H27Cl2N5Pureza:98.33%Cor e Forma:SolidPeso molecular:432.39MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Fórmula:C20H22O6Pureza:99.87%Cor e Forma:SolidPeso molecular:358.39C29
CAS:C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.Fórmula:C16H15NO4Pureza:96.34% - 97.37%Cor e Forma:SolidPeso molecular:285.29TLR7 agonist 2
CAS:TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).Fórmula:C17H16N6O2Pureza:99.33%Cor e Forma:SolidPeso molecular:336.35Ref: TM-T4258
1mg157,00€2mg240,00€5mg495,00€10mg717,00€25mg1.111,00€50mg1.501,00€100mg2.023,00€1mL*10mM (DMSO)365,00€Desethyl chloroquine diphosphate
CAS:Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.Fórmula:C16H28ClN3O8P2Pureza:99.72%Cor e Forma:SolidPeso molecular:487.81TLR7/8-IN-1
CAS:TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.Fórmula:C29H40N8O2Pureza:99.83%Cor e Forma:SolidPeso molecular:532.68PF-4878691
CAS:PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.Fórmula:C17H23N5O2SPureza:98.43%Cor e Forma:SolidPeso molecular:361.46Ref: TM-T16506
1mg48,00€5mg144,00€10mg235,00€25mg512,00€50mg847,00€100mg1.378,00€1mL*10mM (DMSO)159,00€TLR7/8/9-IN-1
CAS:TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.Fórmula:C27H37N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:435.6Ref: TM-T39669
1mg52,00€2mg73,00€5mg117,00€10mg188,00€25mg306,00€50mg449,00€100mg610,00€200mg872,00€1mL*10mM (DMSO)170,00€AN3485 Hydrochloride
CAS:AN3485 Hydrochloride is an anti-inflammatory agent and a TLRs inhibitor, reducing ear swelling induced by PMA.Fórmula:C14H14BCl2NO3Pureza:99.76%Cor e Forma:SolidPeso molecular:325.98ODN 1668
CAS:ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN), used as an agonist for TLR9, and upregulates the level of IgM.Cor e Forma:SolidPeso molecular:6364.1CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Fórmula:C17H15NO2Pureza:99.01%Cor e Forma:SolidPeso molecular:265.31Ref: TM-T7317
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg236,00€50mg432,00€100mg638,00€1mL*10mM (DMSO)87,00€Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Fórmula:C36H59N5O2Pureza:98.61%Cor e Forma:SolidPeso molecular:593.89Ref: TM-T17032
1mg172,00€2mg235,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)462,00€Procyanidin B1
CAS:Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Fórmula:C30H26O12Pureza:98.00% - 99.13%Cor e Forma:Red-Brown PowderPeso molecular:578.52Ref: TM-TQ0205
1mg51,00€5mg170,00€10mg274,00€25mg465,00€50mg652,00€100mg920,00€1mL*10mM (DMSO)221,00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Fórmula:C17H23N5OPureza:99.93%Cor e Forma:SolidPeso molecular:313.4Ref: TM-T13167
1mg64,00€5mg140,00€10mg226,00€25mg368,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)156,00€Afimetoran
CAS:Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.Fórmula:C26H32N6OPureza:99.89%Cor e Forma:SolidPeso molecular:444.57Ref: TM-T39654
1mg92,00€5mg187,00€10mg311,00€25mg530,00€50mg748,00€100mg1.064,00€1mL*10mM (DMSO)215,00€Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Fórmula:C16H15F3N4Pureza:97.08% - 99.38%Cor e Forma:SolidPeso molecular:320.31CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Fórmula:C14H12N4OPureza:99.00%Cor e Forma:SolidPeso molecular:252.27Ref: TM-T7347
1mg48,00€5mg88,00€10mg127,00€25mg224,00€50mg349,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)106,00€AZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Fórmula:C29H43N7O5Cor e Forma:SolidPeso molecular:569.7CU-115
CAS:CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.Fórmula:C21H11F7INO2Pureza:100%Cor e Forma:SolidPeso molecular:569.21ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFórmula:C11H9BrClN3O4SPureza:99.15%Cor e Forma:SolidPeso molecular:394.63Ref: TM-T39115
1mg123,00€5mg298,00€10mg472,00€25mg748,00€50mg1.026,00€100mg1.406,00€1mL*10mM (DMSO)328,00€SM-276001
CAS:SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.Fórmula:C16H21N7OPureza:99.37%Cor e Forma:SolidPeso molecular:327.38Ref: TM-T12933
1mg64,00€5mg139,00€10mg202,00€25mg364,00€50mg547,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)153,00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Fórmula:C22H25N5Pureza:99.4%Cor e Forma:SolidPeso molecular:359.47CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Fórmula:C17H13F3N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:362.31Ref: TM-T15017
1mg106,00€2mg150,00€5mg216,00€10mg283,00€25mg356,00€50mg432,00€100mg625,00€500mg1.293,00€1mL*10mM (DMSO)188,00€TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Fórmula:C21H25N5OPureza:98%Cor e Forma:SolidPeso molecular:363.46DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Fórmula:C19H28N8O2Pureza:99.12%Cor e Forma:SolidPeso molecular:400.48TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Fórmula:C23H31N7Pureza:98%Cor e Forma:SoildPeso molecular:405.54Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Fórmula:C15H13F5N2O2Pureza:98%Cor e Forma:SolidPeso molecular:348.27Semapimod tetrahydrochloride
CAS:Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.Fórmula:C34H56Cl4N18O2Pureza:99.8%Cor e Forma:SolidPeso molecular:890.74M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Fórmula:C13H13Cl2N3OSPureza:96.85%Cor e Forma:SolidPeso molecular:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Fórmula:C23H31N3O3Pureza:99.88%Cor e Forma:SolidPeso molecular:397.51Ref: TM-T61882
1mg103,00€5mg246,00€10mg395,00€25mg785,00€50mg1.130,00€100mg1.768,00€200mg2.357,00€1mL*10mM (DMSO)271,00€TH1020
CAS:TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.Fórmula:C23H15N7S2Pureza:99.23%Cor e Forma:SolidPeso molecular:453.54SM360320
CAS:SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.Fórmula:C15H17N5O3Pureza:98.4%Cor e Forma:SolidPeso molecular:315.33Ref: TM-T19675
1mg116,00€5mg244,00€10mg364,00€25mg562,00€50mg780,00€100mg1.035,00€500mg2.100,00€1mL*10mM (DMSO)269,00€CU-CPD107
CAS:CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Fórmula:C16H21IN2O2Pureza:98.86%Cor e Forma:SolidPeso molecular:400.25
