Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Produtos da "Sinalização JAK/STAT"
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Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Fórmula:C20H18FN5O3Pureza:98.05%Cor e Forma:SolidPeso molecular:395.39Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:235.26JAK-IN-10
CAS:JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.Fórmula:C20H18FN5O3SPureza:98.88%Cor e Forma:SolidPeso molecular:427.45Ref: TM-T13571
1mg87,00€5mg177,00€10mg260,00€25mg429,00€50mg605,00€100mg815,00€500mg1.624,00€1mL*10mM (DMSO)188,00€JAK kinase-IN-1
CAS:JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Fórmula:C17H19F2N7OSPureza:98%Cor e Forma:SolidPeso molecular:407.44Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Fórmula:C22H28N6O8Pureza:99.19% - 99.75%Cor e Forma:SolidPeso molecular:504.49ITK inhibitor 2
CAS:ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of 2 nM.Fórmula:C25H33N5O2Cor e Forma:SolidPeso molecular:435.56TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:97.38% - 99.1%Cor e Forma:SolidPeso molecular:504.64(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Fórmula:C13H24O5Cor e Forma:SolidPeso molecular:260.33Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Cor e Forma:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)177,00€G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Fórmula:C22H19F2NO3Pureza:97.30%Cor e Forma:SolidPeso molecular:383.39Ref: TM-T8742
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg374,00€100mg523,00€200mg710,00€1mL*10mM (DMSO)105,00€2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Fórmula:C16H13Cl2N3O2Pureza:98.77%Cor e Forma:SolidPeso molecular:350.2RO495
CAS:RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFórmula:C17H14Cl2N6OPureza:97.94%Cor e Forma:SolidPeso molecular:389.24Ref: TM-T22416
1mg64,00€2mg87,00€5mg117,00€10mg183,00€25mg354,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)140,00€JAK-IN-5 hydrochloride
CAS:JAK-IN-5 hydrochloride is a JAK inhibitor [1].Fórmula:C27H32ClFN6OCor e Forma:SolidPeso molecular:511.03Cenacitinib
CAS:Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Fórmula:C19H19F2N7O3Cor e Forma:SolidPeso molecular:431.40JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Fórmula:C28H38N6O5SPureza:98%Cor e Forma:SolidPeso molecular:570.7SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Fórmula:C20H22F3N5OPureza:100% - 99.84%Cor e Forma:SolidPeso molecular:405.42Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Fórmula:C25H26F2N6O2Pureza:98.71%Cor e Forma:SoildPeso molecular:480.51Ref: TM-T67907
1mg96,00€2mg139,00€5mg227,00€10mg354,00€25mg653,00€50mg938,00€100mg1.454,00€500mg2.822,00€JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Fórmula:C14H10ClN3OS2Pureza:99.38%Cor e Forma:SolidPeso molecular:335.83JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.Fórmula:C25H32N8O2Pureza:99.64%Cor e Forma:SolidPeso molecular:476.57WP1066
CAS:WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Fórmula:C17H14BrN3OPureza:98.92% - 99.73%Cor e Forma:SolidPeso molecular:356.22JAK3 covalent inhibitor-1
CAS:JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM andFórmula:C22H17FN6O2SPureza:98%Cor e Forma:SolidPeso molecular:448.47Dual Cathepsin L/JAK-IN-1
CAS:DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).Fórmula:C19H18ClN5Cor e Forma:SolidPeso molecular:351.833GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Fórmula:C20H22F3N7OSCor e Forma:SolidPeso molecular:465.5Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Fórmula:C18H19F3N6OPureza:100% - 99.45%Cor e Forma:SolidPeso molecular:392.38Ref: TM-T2636
1mg38,00€2mg52,00€5mg79,00€10mg110,00€25mg217,00€50mg329,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)88,00€Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.84% - 98.69%Cor e Forma:SolidPeso molecular:339.35Ref: TM-T5093
1mg89,00€2mg131,00€5mg183,00€10mg278,00€25mg490,00€50mg710,00€100mg998,00€1mL*10mM (DMSO)202,00€Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Cor e Forma:SolidPeso molecular:472.58CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Fórmula:C26H24ClN3O3Pureza:95.88%Cor e Forma:SolidPeso molecular:461.94Ref: TM-T1834
1mg37,00€5mg80,00€10mg106,00€25mg208,00€50mg311,00€100mg472,00€200mg658,00€1mL*10mM (DMSO)81,00€Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Fórmula:C23H25ClFN7OPureza:99.33% - 99.86%Cor e Forma:SolidPeso molecular:469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€JAK2-IN-7
CAS:JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Fórmula:C26H33N7OPureza:98.71%Cor e Forma:SolidPeso molecular:459.59Ref: TM-T35900
1mg145,00€5mg354,00€10mg630,00€25mg1.301,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)358,00€AZ-3
CAS:AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Fórmula:C20H28FN7Pureza:98%Cor e Forma:SolidPeso molecular:385.48JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Fórmula:C29H26FN5O3SPureza:98%Cor e Forma:SolidPeso molecular:543.61JAK3-IN-7
CAS:JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFórmula:C17H20N6OPureza:98.81%Cor e Forma:SolidPeso molecular:324.38Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.76%Cor e Forma:SolidPeso molecular:318.24Ref: TM-T8114
1mg88,00€5mg202,00€10mg303,00€25mg510,00€50mg733,00€100mg998,00€500mg1.985,00€1mL*10mM (DMSO)213,00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Fórmula:C17H20N8O2SPureza:99.89%Cor e Forma:SoildPeso molecular:400.46RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:97.29% - 99.91%Cor e Forma:SolidPeso molecular:545.63STAT3-IN-18
CAS:STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells andFórmula:C18H24Cl2N2O6PtPureza:98%Cor e Forma:SolidPeso molecular:630.38Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Cor e Forma:SolidPeso molecular:445.54Ref: TM-T2487
1mg44,00€2mg55,00€5mg79,00€10mg106,00€25mg185,00€50mg283,00€100mg432,00€200mg605,00€500mg938,00€1mL*10mM (DMSO)86,00€Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Fórmula:C20H26O5Pureza:100% - 99.74%Cor e Forma:SolidPeso molecular:346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.44%Cor e Forma:SolidPeso molecular:273.23K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Fórmula:C18H18N4OPureza:97.88%Cor e Forma:SolidPeso molecular:306.36Ref: TM-T27704
1mg185,00€2mg279,00€5mg426,00€10mg627,00€25mg938,00€50mg1.320,00€100mg1.786,00€500mg3.591,00€1mL*10mM (DMSO)415,00€JAK-IN-14
CAS:JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Fórmula:C19H15FN4OPureza:98.27%Cor e Forma:SolidPeso molecular:334.35Ref: TM-T9764
1mg139,00€5mg330,00€10mg492,00€25mg797,00€50mg1.103,00€100mg1.491,00€200mg1.985,00€1mL*10mM (DMSO)340,00€STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Fórmula:C25H27N5OCor e Forma:SolidPeso molecular:413.51JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFórmula:C19H18N4O3Pureza:97.46% - 99.94%Cor e Forma:SolidPeso molecular:350.37CEP-33779
CAS:CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Fórmula:C24H26N6O2SPureza:98.81% - ≥95%Cor e Forma:SolidPeso molecular:462.57Ref: TM-T6122
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg245,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)97,00€JAK1-IN-11
CAS:JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.Fórmula:C26H36N6O4SPureza:98%Cor e Forma:SolidPeso molecular:528.67Lorpucitinib
CAS:Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Fórmula:C22H28N6O2Pureza:99.72%Cor e Forma:SolidPeso molecular:408.5Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50Ref: TM-T35898
1mg88,00€5mg187,00€10mg298,00€25mg597,00€50mg938,00€100mg1.510,00€200mg2.072,00€1mL*10mM (DMSO)207,00€VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Fórmula:C27H27N3O3Peso molecular:441.522Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:97.72% - 99.95%Cor e Forma:SolidPeso molecular:418.46JAK-IN-30
CAS:JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Fórmula:C19H26N8SPureza:98%Cor e Forma:SolidPeso molecular:398.53GS-829845
CAS:GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFórmula:C17H19N5O2SPureza:99.78%Cor e Forma:SolidPeso molecular:357.43Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Fórmula:C25H29F2N7O4SPureza:99.82% - 99.97%Cor e Forma:SolidPeso molecular:561.6JAK-IN-25
CAS:JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Fórmula:C19H17N5O4Pureza:98%Cor e Forma:SolidPeso molecular:379.37JAK-IN-5
CAS:JAK-IN-5 is a JAK inhibitor.Fórmula:C27H31FN6OPureza:97.78% - 98.78%Cor e Forma:SolidPeso molecular:474.57Ref: TM-T11710
1mg187,00€5mg391,00€10mg582,00€25mg929,00€50mg1.254,00€100mg1.691,00€500mg3.382,00€1mL*10mM (DMSO)567,00€Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.85%Cor e Forma:SolidPeso molecular:611.51Jaspamycin
CAS:Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Fórmula:C12H12N4O5Cor e Forma:SolidPeso molecular:292.25JI069
CAS:JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.Fórmula:C15H12Cl2N2O4SPureza:98.01%Cor e Forma:SolidPeso molecular:387.24FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Fórmula:C21H20F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:430.47Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:99.13%Cor e Forma:SolidPeso molecular:767AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€Upadacitinib
CAS:Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Fórmula:C17H19F3N6OPureza:98.96% - 99.93%Cor e Forma:SolidPeso molecular:380.37Ref: TM-T7503
1mg47,00€2mg62,00€5mg89,00€10mg130,00€25mg220,00€50mg306,00€100mg434,00€200mg662,00€500mg1.169,00€1mL*10mM (DMSO)48,00€JAK-IN-28
CAS:JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Fórmula:C20H18ClN7OPureza:98%Cor e Forma:SolidPeso molecular:407.86ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFórmula:C24H28N4O5Pureza:98%Cor e Forma:SolidPeso molecular:452.5Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Cor e Forma:Odour SolidJBJ-02-112-05
CAS:JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Fórmula:C27H20N4O2SPureza:98%Cor e Forma:SolidPeso molecular:464.54GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Fórmula:C20H18F2N6O5SCor e Forma:SolidPeso molecular:492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Cor e Forma:Odour SolidFosifidancitinib
CAS:Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.Fórmula:C21H21FN5O7PPureza:99.55%Cor e Forma:SolidPeso molecular:505.39Ref: TM-T38624
1mg87,00€2mg124,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Fórmula:C22H23FN4O3SPureza:98.36%Cor e Forma:SolidPeso molecular:442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€S-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Fórmula:C17H18N6Pureza:98%Cor e Forma:SolidPeso molecular:306.37LNK01004
CAS:LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.Fórmula:C26H31N7O2Cor e Forma:SolidPeso molecular:473.57Londamocitinib
CAS:Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Fórmula:C28H31F2N7O4SPureza:99.47%Cor e Forma:SolidPeso molecular:599.65Ref: TM-T11706
1mg180,00€5mg439,00€10mg597,00€25mg905,00€50mg1.169,00€100mg1.568,00€1mL*10mM (DMSO)567,00€Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Fórmula:C16H16ClN5O2Cor e Forma:SolidPeso molecular:345.78JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Fórmula:C21H21N5O2Pureza:99.21%Cor e Forma:SolidPeso molecular:375.42(R)-9b
CAS:(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.Fórmula:C20H27ClN6OCor e Forma:SolidPeso molecular:402.92SD-1029
CAS:SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Fórmula:C25H32Br2Cl2N2O3Cor e Forma:SolidPeso molecular:639.25Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Fórmula:C14H21N5O2SPureza:99.09% - 99.91%Cor e Forma:SolidPeso molecular:323.41Ref: TM-TQ0037
1mg85,00€2mg107,00€5mg167,00€10mg284,00€25mg467,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)188,00€WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Fórmula:C16H14Br2ClN3O3Pureza:99.49%Cor e Forma:SolidPeso molecular:491.56WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Fórmula:C16H14BrN3O3Pureza:98% - 99.6%Cor e Forma:SolidPeso molecular:376.2TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Fórmula:C18H11BrN2O2Pureza:97% - 99.64%Cor e Forma:SolidPeso molecular:367.2Ref: TM-T2253
1mg35,00€5mg64,00€10mg88,00€25mg187,00€50mg284,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)97,00€PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Fórmula:C25H30N8O2Pureza:98%Cor e Forma:SolidPeso molecular:474.56PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Fórmula:C19H22N4O2Pureza:98%Cor e Forma:SolidPeso molecular:338.4JDTic dihydrochloride
CAS:JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.Fórmula:C28H41Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:538.55HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.Fórmula:C15H15N5O2SPureza:95.04%Cor e Forma:SolidPeso molecular:329.38Oclacitinib maleate
CAS:Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Fórmula:C15H23N5O2S·C4H4O4Pureza:99.17%Cor e Forma:SolidPeso molecular:453.51Ref: TM-T6914
1mg39,00€2mg50,00€5mg79,00€10mg99,00€25mg170,00€50mg271,00€100mg457,00€1mL*10mM (DMSO)86,00€
