STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Produtos da "STAT"
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inS3-54A18
CAS:inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Fórmula:C23H16ClNO2Pureza:99.54%Cor e Forma:SolidPeso molecular:373.83Ref: TM-T15582
2mg42,00€5mg65,00€10mg93,00€25mg160,00€50mg226,00€100mg320,00€200mg452,00€1mL*10mM (DMSO)71,00€SH5-07
CAS:SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).Fórmula:C29H28F5N3O5SPureza:95.54%Cor e Forma:SolidPeso molecular:625.61Ref: TM-TQ0052
1mg37,00€5mg80,00€10mg117,00€25mg197,00€50mg294,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)99,00€STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Fórmula:C19H16N2O4SCor e Forma:SolidPeso molecular:368.41BP-1-102
CAS:BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Fórmula:C29H27F5N2O6SPureza:99.25% - 99.81%Cor e Forma:SolidPeso molecular:626.59Ref: TM-T3708
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg210,00€50mg354,00€100mg522,00€1mL*10mM (DMSO)104,00€Colivelin
CAS:Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).Fórmula:C119H206N32O35Pureza:96.56%Cor e Forma:SolidPeso molecular:2645.1Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Fórmula:C30H52O3Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:460.73WZ-2-033
CAS:WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Fórmula:C25H18F3N3O4SCor e Forma:SolidPeso molecular:513.49NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Cor e Forma:SolidPeso molecular:412.26MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Fórmula:C15H12N2O2Pureza:99.74%Cor e Forma:SolidPeso molecular:252.27Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Fórmula:C12H9N3O5Pureza:98.31% - 99.87%Cor e Forma:Yellow SolidPeso molecular:275.22STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFórmula:C30H27F4N7SPureza:98%Cor e Forma:SolidPeso molecular:593.64Scutellarin
CAS:Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.Fórmula:C21H18O12Pureza:95.86% - 99.32%Cor e Forma:SolidPeso molecular:462.36AS1810722
CAS:AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Fórmula:C25H25F2N7OPureza:99.13%Cor e Forma:SolidPeso molecular:477.51Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.Fórmula:C20H18O6Pureza:99.81%Cor e Forma:Off White PowderPeso molecular:354.35STAT3 degrader-2
CAS:STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFórmula:C59H62N9O13PPureza:98%Cor e Forma:SolidPeso molecular:1136.15Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66%Cor e Forma:SolidPeso molecular:332.39Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Fórmula:C13H8Cl2N2O4Pureza:96.83% - 98.9%Cor e Forma:Pale Yellow Crystals SolidPeso molecular:327.12(R)-Lisofylline
CAS:(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Fórmula:C13H20N4O3Pureza:99.50%Cor e Forma:SolidPeso molecular:280.32C188-9
CAS:C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.Fórmula:C27H21NO5SPureza:100% - 99.19%Cor e Forma:SolidPeso molecular:471.52Ref: TM-T4650
1mg46,00€2mg59,00€5mg87,00€10mg123,00€25mg250,00€50mg398,00€100mg593,00€500mg1.264,00€1mL*10mM (DMSO)96,00€STAT3-IN-B9
CAS:STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Fórmula:C20H13NO5SPureza:98.16%Cor e Forma:SolidPeso molecular:379.39Ref: TM-T28865
1mg115,00€2mg162,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)269,00€
