Pim
As quinases Pim são uma família de quinases serina/treonina que desempenham um papel fundamental na sobrevivência celular, proliferação e apoptose. Estas quinases são efetores a jusante na via de sinalização JAK/STAT e estão envolvidas em vários processos fisiológicos, incluindo respostas imunológicas e hematopoiese. A superexpressão das quinases Pim tem sido associada ao desenvolvimento de câncer, tornando-as alvos importantes para a intervenção terapêutica. Na CymitQuimica, oferecemos uma variedade de inibidores e moduladores de quinases Pim de alta qualidade para apoiar sua pesquisa em oncologia, biologia celular e transdução de sinal.
Produtos da "Pim"
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Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:97.72% - 99.95%Cor e Forma:SolidPeso molecular:418.46PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Fórmula:C25H30N8O2Pureza:98%Cor e Forma:SolidPeso molecular:474.56HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.Fórmula:C15H15N5O2SPureza:95.04%Cor e Forma:SolidPeso molecular:329.38Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.81%Cor e Forma:SoildPeso molecular:275.3Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Cor e Forma:Odour SolidSMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:SolidPeso molecular:263.31Ref: TM-T3989
1mg35,00€2mg48,00€5mg70,00€10mg87,00€25mg160,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)92,00€TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Fórmula:C18H11BrN2O2Pureza:97% - 99.64%Cor e Forma:SolidPeso molecular:367.2Ref: TM-T2253
1mg35,00€5mg64,00€10mg88,00€25mg187,00€50mg284,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)97,00€TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Fórmula:C11H6F3NO2SPureza:99.89%Cor e Forma:SolidPeso molecular:273.23PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Fórmula:C27H25BrCl2CuN6OPureza:98%Cor e Forma:SolidPeso molecular:663.88PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Fórmula:C19H22N4O2Pureza:98%Cor e Forma:SolidPeso molecular:338.4AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Cor e Forma:SolidPeso molecular:379.48Ref: TM-T2300
2mg38,00€5mg51,00€10mg74,00€25mg118,00€50mg213,00€100mg378,00€200mg495,00€500mg792,00€1mL*10mM (DMSO)57,00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Fórmula:C22H24N8OPureza:98%Cor e Forma:SolidPeso molecular:416.48AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Fórmula:C22H28ClN5O3Pureza:98.30%Cor e Forma:SolidPeso molecular:445.94HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:99.55%Cor e Forma:SolidPeso molecular:225.24Ref: TM-T9583
1mg35,00€5mg80,00€10mg116,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)77,00€Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:235.26SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Fórmula:C20H22F3N5OPureza:100% - 99.84%Cor e Forma:SolidPeso molecular:405.42GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Fórmula:C20H22F3N7OSCor e Forma:SolidPeso molecular:465.5
