Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Produtos da "Ras"
Ordenar por
ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Fórmula:C21H17ClF2N4O2Pureza:98.88%Cor e Forma:SolidPeso molecular:430.84FTI-277 hydrochloride
CAS:FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Fórmula:C22H30ClN3O3S2Pureza:97.57% - 97.61%Cor e Forma:SolidPeso molecular:484.07Ref: TM-T2700
1mg52,00€2mg73,00€5mg96,00€10mg175,00€25mg320,00€50mg537,00€100mg753,00€1mL*10mM (DMSO)111,00€Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Cor e Forma:SolidPeso molecular:419.31GGTI298 Trifluoroacetate
CAS:GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Fórmula:C27H33N3O3S·C2HF3O2Pureza:100% - 98.29%Cor e Forma:SolidPeso molecular:593.66ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.81%Cor e Forma:SolidPeso molecular:430.84Ref: TM-T10376
1mg52,00€5mg117,00€10mg170,00€25mg325,00€50mg469,00€100mg615,00€1mL*10mM (DMSO)134,00€SOS2 ligand 1
CAS:SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Fórmula:C19H21N5OCor e Forma:SolidPeso molecular:335.403ML141
CAS:ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Fórmula:C22H21N3O3SPureza:99.36% - 99.56%Cor e Forma:SolidPeso molecular:407.49Ref: TM-T2463
1mg39,00€2mg50,00€5mg72,00€10mg110,00€25mg225,00€50mg406,00€100mg582,00€500mg1.254,00€1mL*10mM (DMSO)74,00€ESI-08
CAS:ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.Fórmula:C20H23N3OSPureza:99.05%Cor e Forma:SolidPeso molecular:353.48NSC 23766 trihydrochloride
CAS:NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Fórmula:C24H35N7·3HClPureza:96.48% - 99.54%Cor e Forma:SolidPeso molecular:530.96MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 98.74%Cor e Forma:SolidPeso molecular:338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Cor e Forma:SolidPeso molecular:541.61Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T9407
1mg40,00€5mg80,00€10mg116,00€25mg205,00€50mg340,00€100mg485,00€200mg655,00€1mL*10mM (DMSO)88,00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Cor e Forma:SolidPeso molecular:444.86Ref: TM-T7764
2mg42,00€5mg65,00€10mg99,00€25mg182,00€50mg279,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)70,00€6H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Cor e Forma:SolidPeso molecular:476.12KRAS inhibitor-32
CAS:KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Fórmula:C29H35FN10OS2Cor e Forma:SolidPeso molecular:622.78Adagrasib
CAS:View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Fórmula:C32H35ClFN7O2Pureza:99.10% - 99.9%Cor e Forma:SolidPeso molecular:604.12LUNA18
CAS:LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation.Fórmula:C73H105F5N12O12Pureza:98%Cor e Forma:SolidPeso molecular:1437.68KRas G12C inhibitor 4
CAS:KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Fórmula:C33H38ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:600.15NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Fórmula:C19H18O8Pureza:98% - 99.57%Cor e Forma:SolidPeso molecular:374.34
