p38 MAPK
As p38 MAPKs são um subgrupo de MAPKs que respondem a sinais de estresse e estão envolvidas na regulação da inflamação, diferenciação celular, apoptose e autofagia. A sinalização de p38 MAPK é crucial nas respostas imunes e está implicada em várias doenças, incluindo condições inflamatórias crônicas, câncer e distúrbios neurodegenerativos. Na CymitQuimica, oferecemos uma gama abrangente de inibidores e moduladores de p38 MAPK para apoiar sua pesquisa em inflamação, resposta ao estresse e desenvolvimento terapêutico.
Produtos da "p38 MAPK"
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Lucidenic acid D
CAS:Lucidenic acid D2 is a nartural product from G. lucidum AF.Fórmula:C29H38O8Pureza:98%Cor e Forma:SolidPeso molecular:514.61Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Fórmula:C27H30O14Pureza:98.11% - 98.87%Cor e Forma:SolidPeso molecular:578.52PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Fórmula:C22H19BrF2N2O3Pureza:97.79% - 97.90%Cor e Forma:SolidPeso molecular:477.3Ref: TM-T1974
1mg46,00€5mg94,00€10mg144,00€25mg255,00€50mg406,00€100mg628,00€500mg1.320,00€1mL*10mM (DMSO)97,00€Bisabolangelone
CAS:Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.Fórmula:C15H20O3Pureza:98.91%Cor e Forma:SolidPeso molecular:248.32Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Fórmula:C14H8O5Cor e Forma:SolidPeso molecular:256.213-Methyl Adenine
CAS:Applications 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)Fórmula:C6H7N5Cor e Forma:White SolidPeso molecular:149.15p38 Kinase inhibitor 7
CAS:p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Fórmula:C22H25FN6OCor e Forma:SolidPeso molecular:408.4725,6,7-TRIMETHOXYFLAVONE
CAS:5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and exhibits anti-inflammatory properties.Fórmula:C18H16O5Pureza:99.05% - 99.11%Cor e Forma:SolidPeso molecular:312.322-Aminooctadecane-1,3,4-Triol
CAS:2-Aminooctadecane-1,3,4-Triol (Phytosphingosine) is a natural product.Fórmula:C18H39NO3Pureza:≥98%Cor e Forma:SolidPeso molecular:317.51p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:97.79%Cor e Forma:SolidPeso molecular:332.42SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64% - 99.64%Cor e Forma:SolidPeso molecular:328.69Ref: TM-T22115
5mg47,00€10mg74,00€25mg135,00€50mg188,00€100mg283,00€200mg411,00€1mL*10mM (DMSO)50,00€Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Fórmula:C30H48O5Pureza:96.91% - 99.97%Cor e Forma:SolidPeso molecular:488.7Samidin
CAS:Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.Fórmula:C21H22O7Pureza:98%Cor e Forma:SolidPeso molecular:386.4Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFórmula:C22H30O2Pureza:98%Cor e Forma:SolidPeso molecular:326.47CAL-101
CAS:Produto ControladoApplications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor. References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);Fórmula:C22H18FN7OCor e Forma:Light BrownPeso molecular:415.40SSK1
CAS:SSK1 is a senescent cell-killing and β-galactosidase-targeting precursor compound that activates phosphorylation levels of p38 MAPK in senescent cells.Fórmula:C31H34F2N4O18Pureza:98.97% - 99.83%Cor e Forma:SolidPeso molecular:788.61SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Fórmula:C16H12FN3SPureza:98% - 99.68%Cor e Forma:SolidPeso molecular:297.35p38 MAPK-IN-1
CAS:p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.Fórmula:C21H14F2N2OPureza:98%Cor e Forma:SolidPeso molecular:348.35Esculin
CAS:Esculin (Aesculin) is a glucoside found in horse chestnuts.Fórmula:C15H16O9Pureza:99.46% - 99.83%Cor e Forma:Cream PowderPeso molecular:340.28BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Cor e Forma:SolidPeso molecular:442.95Ref: TM-T3462
1mg35,00€5mg71,00€10mg101,00€25mg170,00€50mg264,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)78,00€
