P-gp
A P-glicoproteína é uma bomba de efluxo dependente de ATP que transporta uma ampla variedade de substratos, incluindo medicamentos, toxinas e lipídios, para fora das células. Ela desempenha um papel crítico na resistência a medicamentos, particularmente no câncer, ao reduzir a concentração intracelular de agentes quimioterápicos. A P-gp também está envolvida na barreira hematoencefálica, influenciando a exposição do sistema nervoso central a vários compostos. Na CymitQuimica, oferecemos uma variedade de moduladores de P-gp para apoiar sua pesquisa em resistência a medicamentos, farmacocinética e desenvolvimento terapêutico.
Produtos da "P-gp"
Ordenar por
49 produtos desta categoria.
Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Fórmula:C38H36N6O7Pureza:99.93%Cor e Forma:SolidPeso molecular:688.73Ref: TM-T8426
1mg48,00€2mg65,00€5mg96,00€10mg144,00€25mg246,00€50mg380,00€100mg557,00€1mL*10mM (DMSO)134,00€Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:93.19% - 93.19%Cor e Forma:SolidPeso molecular:518.51Ref: TM-TN4761
1mg163,00€5mg320,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)410,00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Fórmula:C39H42N6O11SPureza:99.37%Cor e Forma:SolidPeso molecular:802.85Ref: TM-T9173
1mg69,00€2mg88,00€5mg126,00€10mg195,00€25mg325,00€50mg467,00€100mg680,00€200mg882,00€500mg1.320,00€1mL*10mM (DMSO)187,00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Fórmula:C34H33N3O5Pureza:100% - 99.62%Cor e Forma:SolidPeso molecular:563.64Ref: TM-T2657
5mg42,00€10mg63,00€25mg107,00€50mg188,00€100mg283,00€200mg472,00€500mg753,00€1mL*10mM (DMSO)57,00€Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Fórmula:C40H58N4O18S2Pureza:98.13%Cor e Forma:SolidPeso molecular:947.04Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Fórmula:C45H73NO15Pureza:99.17% - 99.88%Cor e Forma:SolidPeso molecular:868.06Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Fórmula:C26H37ClN2O4Pureza:99.47%Cor e Forma:SolidPeso molecular:477.04Ref: TM-T16339
1mg37,00€5mg111,00€10mg187,00€25mg315,00€50mg472,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)116,00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Fórmula:C23H25FN6Pureza:99.31%Cor e Forma:SolidPeso molecular:404.48coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Fórmula:C20H20O6Pureza:97.09%Cor e Forma:SolidPeso molecular:356.37MCI826
CAS:MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model ofFórmula:C22H28N2O3SPureza:98.73%Cor e Forma:SolidPeso molecular:400.53Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.51% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Fórmula:C63H111N11O12Pureza:100% - 95%Cor e Forma:SolidPeso molecular:1214.62Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Fórmula:C24H30O7Pureza:98.39%Cor e Forma:SolidPeso molecular:430.49Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Cor e Forma:Light Amber SemisolidPeso molecular:328.29775Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Fórmula:C23H27FN4O2Pureza:99.73%Cor e Forma:Crystalline SolidPeso molecular:410.48Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Fórmula:C16H24NO5·CNSPureza:98.19% - ≥95%Cor e Forma:SolidPeso molecular:368.45Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Cor e Forma:SolidPeso molecular:494P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Fórmula:C32H31N5O2Pureza:98.65%Cor e Forma:SolidPeso molecular:517.62Ref: TM-T12341
5mg50,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€1mL*10mM (DMSO)58,00€Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Fórmula:C17H19NO3Pureza:100% - 97.79%Cor e Forma:SolidPeso molecular:285.34γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Cor e Forma:SolidPeso molecular:410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Fórmula:C32H31F2N3O2Cor e Forma:SolidPeso molecular:527.6Evodine
CAS:1. Evodine has antinociceptive activity.Fórmula:C18H19NO5Pureza:98%Cor e Forma:SolidPeso molecular:329.35Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Fórmula:C19H18O8Pureza:97.43% - 98.53%Cor e Forma:SolidPeso molecular:374.34Ref: TM-TJS1159
1mg60,00€5mg127,00€10mg188,00€25mg348,00€50mg512,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)226,00€Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Fórmula:C32H31F2N3O2·3HClPureza:100% - 99.55%Cor e Forma:SolidPeso molecular:636.99PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Fórmula:C26H23N3OPureza:98% - 98.53%Cor e Forma:SolidPeso molecular:393.48Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Fórmula:C21H21F2N3OSPureza:99.58%Cor e Forma:SolidPeso molecular:401.47Ref: TM-T13383
1mg96,00€5mg205,00€10mg309,00€25mg557,00€50mg838,00€100mg1.216,00€1mL*10mM (DMSO)221,00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:407.5Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Fórmula:C11H10N4S3Pureza:99.15%Cor e Forma:SolidPeso molecular:294.42Ref: TM-T8596
1mg43,00€5mg88,00€10mg119,00€25mg250,00€50mg389,00€100mg550,00€200mg785,00€1mL*10mM (DMSO)87,00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Fórmula:C43H52N4O5Pureza:98.54%Cor e Forma:SolidPeso molecular:704.9Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Fórmula:C39H37F3N4O5Pureza:98.74%Cor e Forma:SoildPeso molecular:698.73YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:97.50%Cor e Forma:SolidPeso molecular:663.6Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Fórmula:C38H38N4O6Pureza:98.07% - 99.17%Cor e Forma:SolidPeso molecular:646.73Larotaxel
CAS:Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in breast and bladder cancer.Fórmula:C45H53NO14Pureza:99.22%Cor e Forma:SolidPeso molecular:831.9Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Fórmula:C39H40N6O10SPureza:99.84%Cor e Forma:SolidPeso molecular:784.83Ref: TM-T11578L
2mg42,00€5mg62,00€10mg88,00€25mg155,00€50mg250,00€100mg393,00€500mg893,00€1mL*10mM (DMSO)74,00€Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:491.06Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Fórmula:C38H52N6O7Pureza:98% - 99.95%Cor e Forma:Crystalline SolidPeso molecular:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Cor e Forma:SolidPeso molecular:802.93Ref: TM-T0100
5mg47,00€10mg62,00€25mg95,00€50mg120,00€100mg180,00€200mg264,00€500mg449,00€1mL*10mM (DMSO)52,00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Fórmula:C16H24NO5Pureza:98% - 99.85%Cor e Forma:White Or Light-Tan SolidPeso molecular:310.37Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFórmula:C43H63NO11Pureza:99.84%Cor e Forma:SolidPeso molecular:769.96ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Fórmula:C32H38N4OPureza:98.86%Cor e Forma:SolidPeso molecular:494.67Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFórmula:C34H35N3O7Pureza:99.43%Cor e Forma:SolidPeso molecular:597.66Ref: TM-T11071
1mg39,00€2mg50,00€5mg85,00€10mg125,00€25mg245,00€50mg472,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)96,00€Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Fórmula:C20H20O7Pureza:99.05% - ≥95%Cor e Forma:SolidPeso molecular:372.37P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Fórmula:C30H28N2O6Pureza:99.58%Cor e Forma:SoildPeso molecular:512.55FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Fórmula:C26H25NO4Pureza:99.84%Cor e Forma:SolidPeso molecular:415.48Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Fórmula:C20H33N3O3Pureza:98.80%Cor e Forma:SolidPeso molecular:363.49Ref: TM-T21640
2mg35,00€5mg50,00€10mg96,00€25mg188,00€50mg329,00€100mg565,00€200mg818,00€1mL*10mM (DMSO)55,00€Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Fórmula:C27H38N2O4Pureza:99.53%Cor e Forma:OilPeso molecular:454.6Ref: TM-T20656
10mg35,00€25mg51,00€50mg73,00€100mg96,00€200mg143,00€500mg230,00€1mL*10mM (DMSO)55,00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFórmula:C30H52O3Pureza:98.03% - 98.91%Cor e Forma:SolidPeso molecular:460.73Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27%Cor e Forma:Prisms From Methanol + Ether SolidPeso molecular:550.64Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Cor e Forma:Cream Fine PowderPeso molecular:480.43
