PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.11% - 99.42%Cor e Forma:Off-White SolidPeso molecular:306.36Ref: TM-T19812
1mg69,00€5mg145,00€10mg212,00€25mg358,00€50mg527,00€100mg750,00€1mL*10mM (DMSO)157,00€cis-Tadalafil
CAS:Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.Fórmula:C22H19N3O4Pureza:≥98%Cor e Forma:SolidPeso molecular:389.4Anti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Cor e Forma:Odour LiquidThioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Fórmula:C24H29ClN6OSPureza:98.73%Cor e Forma:SolidPeso molecular:485.05Ref: TM-T9773
1mg84,00€5mg178,00€10mg266,00€25mg434,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)205,00€Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Fórmula:C23H32N6O4SPureza:99.88%Cor e Forma:White SolidPeso molecular:488.6Ref: TM-T8919
2mg42,00€5mg64,00€10mg92,00€25mg187,00€50mg281,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)78,00€Ketotifen fumarate
CAS:Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.Fórmula:C23H23NO5SPureza:99.25% - 99.73%Cor e Forma:SolidPeso molecular:425.5Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Fórmula:C25H20N4OPureza:98.82% - 99.81%Cor e Forma:SolidPeso molecular:392.45Ref: TM-T16499
1mg43,00€2mg55,00€5mg92,00€10mg150,00€25mg245,00€50mg365,00€100mg547,00€1mL*10mM (DMSO)92,00€Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Fórmula:C17H12Cl2N2O6SPureza:98%Cor e Forma:SolidPeso molecular:443.26PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Cor e Forma:SolidPeso molecular:369.42N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Fórmula:C8H9NOPureza:99.83%Cor e Forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Cor e Forma:Odour LiquidBAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Fórmula:C22H28BrN5O5Pureza:98.64% - 99.16%Cor e Forma:SolidPeso molecular:522.39Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.45%Cor e Forma:White PowderPeso molecular:390.39TyK2-IN-2
CAS:TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).Fórmula:C16H18N6OPureza:98%Cor e Forma:SolidPeso molecular:310.35ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Fórmula:C21H23Cl2N2O6PPureza:99.52%Cor e Forma:SolidPeso molecular:501.3PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Fórmula:C22H21Cl2N3O5Pureza:98.70% - 99.25%Cor e Forma:SolidPeso molecular:478.33Vardenafil
CAS:Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction.Fórmula:C23H32N6O4SPureza:99.88%Cor e Forma:SolidPeso molecular:488.6Nauclefine
CAS:Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.Fórmula:C18H13N3OPureza:99.92%Cor e Forma:SolidPeso molecular:287.32BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.10%Cor e Forma:SolidPeso molecular:297.35Ref: TM-T12267
1mg52,00€5mg116,00€10mg187,00€25mg325,00€50mg467,00€100mg645,00€200mg872,00€1mL*10mM (DMSO)128,00€MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:100% - 99.67%Cor e Forma:SolidPeso molecular:382.48Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Fórmula:C21H26N6O2Pureza:98.14%Cor e Forma:SolidPeso molecular:394.47FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Fórmula:C15H19F2NO3Pureza:100.00%Cor e Forma:SolidPeso molecular:299.31Ref: TM-T39341
1mg52,00€2mg75,00€5mg116,00€10mg183,00€25mg311,00€50mg444,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)128,00€T-0156
CAS:T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.Fórmula:C31H29N5O7Pureza:100% - 98.42%Cor e Forma:SoildPeso molecular:583.59Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:98.56% - 99.36%Cor e Forma:SolidPeso molecular:240.26Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:99.84%Cor e Forma:SolidPeso molecular:276.72Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:100.00% - 99.76%Cor e Forma:SolidPeso molecular:403.21BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Cor e Forma:SolidPeso molecular:244.27Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Fórmula:C22H21N9O2Pureza:98.49% - 99.21%Cor e Forma:SolidPeso molecular:443.46Ref: TM-T10415
2mg46,00€5mg70,00€10mg101,00€25mg183,00€50mg284,00€100mg455,00€200mg625,00€1mL*10mM (DMSO)78,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.54%Cor e Forma:SolidPeso molecular:220.26PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.25% - 99.06%Cor e Forma:SolidPeso molecular:519.62Ref: TM-T15381
1mg185,00€5mg415,00€10mg613,00€25mg938,00€50mg1.311,00€100mg1.768,00€1mL*10mM (DMSO)520,00€Pumafentrine
CAS:Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.79%Cor e Forma:SolidPeso molecular:477.64PF-05085727
CAS:PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.Fórmula:C20H18F3N7Pureza:98%Cor e Forma:SolidPeso molecular:413.4OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Fórmula:C20H23ClN2O4Pureza:98.92%Cor e Forma:SoildPeso molecular:390.86Ref: TM-T83974
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€1mL*10mM (DMSO)47,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.87%Cor e Forma:SolidPeso molecular:391.45YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Fórmula:C17H16ClN3OPureza:99.84%Cor e Forma:SolidPeso molecular:313.78PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:100%Cor e Forma:SolidPeso molecular:476.55K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:98.63%Cor e Forma:SolidPeso molecular:424.49Ref: TM-T13331
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg475,00€100mg638,00€200mg845,00€1mL*10mM (DMSO)170,00€Avanafil
CAS:Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.Fórmula:C23H26ClN7O3Pureza:98% - 99.03%Cor e Forma:White SolidPeso molecular:483.95Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Fórmula:C20H25NO4Pureza:97.37% - 99.43%Cor e Forma:White SolidPeso molecular:343.42PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Fórmula:C14H15F3N8OSPureza:99.02%Cor e Forma:SolidPeso molecular:400.38Ref: TM-T12422
1mg137,00€5mg235,00€10mg354,00€25mg610,00€50mg885,00€100mg1.320,00€1mL*10mM (DMSO)207,00€MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71Ref: TM-T12103
1mg145,00€2mg207,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.35%Cor e Forma:SolidPeso molecular:441.48Ref: TM-T14217
1mg35,00€2mg47,00€5mg73,00€10mg105,00€25mgA consultar50mgA consultar1mL*10mM (DMSO)82,00€Vardenafil hydrochloride trihydrate
CAS:Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Fórmula:C23H32N6O4S·HCl·3H2OPureza:99.77%Cor e Forma:SolidPeso molecular:579.11Ref: TM-T4097
5mg47,00€10mg70,00€25mg125,00€50mg187,00€100mg298,00€200mg444,00€500mg715,00€1mL*10mM (DMSO)63,00€Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Cor e Forma:SolidPeso molecular:343.4Ref: TM-T7888
1mg133,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€N-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Fórmula:C23H21N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:403.43BI 1015550
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Fórmula:C20H25ClN6O2SPureza:100% - 99.71%Cor e Forma:SoildPeso molecular:448.97Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96%Cor e Forma:SolidPeso molecular:452.55Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61Enpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Fórmula:C23H25NO4SPureza:100%Cor e Forma:SoildPeso molecular:411.51GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.43% - 99.79%Cor e Forma:SolidPeso molecular:439.53CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Cor e Forma:SolidPeso molecular:454.42,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Fórmula:C9H9Cl2F2NO3SPureza:98.60%Cor e Forma:SolidPeso molecular:320.14Ref: TM-T50062
1mg84,00€2mg111,00€5mg172,00€10mg249,00€25mg426,00€50mg627,00€100mg893,00€1mL*10mM (DMSO)172,00€ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:389.4Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Fórmula:C15H22N2O3Pureza:98% - 99.14%Cor e Forma:SolidPeso molecular:278.35Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.06%Cor e Forma:SolidPeso molecular:603.75SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Fórmula:C21H19N7Pureza:99.29%Cor e Forma:SolidPeso molecular:369.42BC 11-38
CAS:BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Fórmula:C15H16N2OS2Pureza:97.71% - 98.72%Cor e Forma:SolidPeso molecular:304.43Ref: TM-T21865
1mg35,00€5mg70,00€10mg97,00€25mg202,00€50mg329,00€100mg527,00€200mg747,00€1mL*10mM (DMSO)81,00€Zardaverine
CAS:Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstructionFórmula:C12H10F2N2O3Pureza:99.11%Cor e Forma:SolidPeso molecular:268.22WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Fórmula:C19H17ClN2O2S2Pureza:99.3%Cor e Forma:SolidPeso molecular:404.93RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Cor e Forma:SolidPeso molecular:411.8Ref: TM-T23256
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)65,00€ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Cor e Forma:SolidPeso molecular:605.56Ref: TM-T11689
1mg74,00€2mg97,00€5mg166,00€10mg303,00€25mg533,00€50mg750,00€100mg1.064,00€1mL*10mM (DMSO)217,00€PF-05180999
CAS:α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.Fórmula:C19H17F3N8Pureza:99.43%Cor e Forma:SolidPeso molecular:414.39Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Cor e Forma:SolidPeso molecular:588.7UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Fórmula:C22H22Cl2N4O4Pureza:100%Cor e Forma:SoildPeso molecular:477.34Ref: TM-T11220L
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)304,00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Fórmula:C14H13ClN4O2Pureza:97.98%Cor e Forma:SolidPeso molecular:304.73Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFórmula:C12H18N4O2Pureza:97.97% - 99.55%Cor e Forma:SolidPeso molecular:250.3Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Fórmula:C14H16N6OPureza:99.63% - 99.77%Cor e Forma:SolidPeso molecular:284.32Ref: TM-T12913
1mg42,00€5mg88,00€10mg127,00€25mg264,00€50mg424,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)87,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SCor e Forma:SolidPeso molecular:632.61THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Cor e Forma:SolidPeso molecular:464.9CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43Anti-ALDH7A1 Antibody-FITC (5P692)
Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.Cor e Forma:Odour LiquidML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Fórmula:C20H20N4O4SPureza:97.93%Cor e Forma:SolidPeso molecular:412.46Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Cor e Forma:SolidPeso molecular:375.38Ref: TM-T6147
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg202,00€50mg354,00€100mg567,00€200mg805,00€500mg1.198,00€1mL*10mM (DMSO)87,00€Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFórmula:C14H10N4OPureza:99.68%Cor e Forma:SolidPeso molecular:250.26Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Fórmula:C24H28N2O6SPureza:98.75% - 99.74%Cor e Forma:SolidPeso molecular:472.55Anagrelide
CAS:Anagrelide (Xagrid) is a Platelet-reducing Agent.Fórmula:C10H7Cl2N3OPureza:100%Cor e Forma:SolidPeso molecular:256.09Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98.32% - 98.97%Cor e Forma:SolidPeso molecular:428.42Ref: TM-T1745
1mg38,00€2mg49,00€5mg79,00€10mg93,00€25mg156,00€50mg256,00€100mg444,00€1mL*10mM (DMSO)79,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFórmula:C24H35N5O3Pureza:100%Cor e Forma:SolidPeso molecular:441.57PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Fórmula:C22H21N5O3Pureza:99.30%Cor e Forma:SolidPeso molecular:403.43Ref: TM-T24656
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)57,00€Mirodenafil dihydrochloride
CAS:Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Fórmula:C26H39Cl2N5O5SPureza:99.64% - 99.78%Cor e Forma:SolidPeso molecular:604.59Bay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Fórmula:C27H32N4O4Pureza:98.14%Cor e Forma:SolidPeso molecular:476.57ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Fórmula:C15H18N6Cor e Forma:SolidPeso molecular:282.34Vardenafil dihydrochloride
CAS:Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Fórmula:C23H34Cl2N6O4SPureza:98%Cor e Forma:SolidPeso molecular:561.52Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Fórmula:C12H12N2O2SPureza:95.52%Cor e Forma:SolidPeso molecular:248.3KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Cor e Forma:SolidPeso molecular:331.8BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Cor e Forma:SolidPeso molecular:257.27Ref: TM-T5101
1mg39,00€5mg101,00€10mg153,00€25mg249,00€50mg359,00€100mg507,00€200mg695,00€1mL*10mM (DMSO)44,00€Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28%Cor e Forma:SolidPeso molecular:381.25Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Fórmula:C15H20N2O4Pureza:98.44% - 99.64%Cor e Forma:SolidPeso molecular:292.33Ref: TM-T31792
1mg226,00€5mg552,00€10mg735,00€25mg1.111,00€50mg1.491,00€100mg2.005,00€200mg2.707,00€1mL*10mM (DMSO)500,00€Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:98.45% - 99.94%Cor e Forma:SolidPeso molecular:477.56Ref: TM-T25376
1mg35,00€5mg96,00€10mg160,00€25mg329,00€50mg533,00€100mg847,00€200mg1.159,00€1mL*10mM (DMSO)105,00€Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T7346
2mg35,00€5mg50,00€10mg81,00€25mg129,00€50mg187,00€100mg259,00€200mg373,00€1mL*10mM (DMSO)56,00€BAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Fórmula:C17H12F4N2O2Pureza:99.98%Cor e Forma:SolidPeso molecular:352.28Ref: TM-T9805
1mg97,00€5mg235,00€10mg376,00€25mg828,00€50mg1.320,00€100mg2.118,00€1mL*10mM (DMSO)259,00€
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