Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Produtos da "Lipoxigenase"
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BI-0115
CAS:BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.Fórmula:C15H14ClN3OPureza:99.34%Cor e Forma:SolidPeso molecular:287.74p-Hexylresorcinol
CAS:Produto ControladoApplications p-Hexylresorcinol shows antiimnflammatory activity acting on the human 5-LO (5-Lipoxygenase) proinflammatory enzyme Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Filosa, R. et al.: Eur. j. Med. Chem., 67, 269 (2013);Fórmula:C12H18O2Cor e Forma:White To Light BrownPeso molecular:194.27LOX-IN-3 dihydrochloride
CAS:LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX).Fórmula:C13H15Cl2FN2O2SPureza:99.86%Cor e Forma:SolidPeso molecular:353.24Ref: TM-T39986
1mg57,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.320,00€1mL*10mM (DMSO)127,00€CBS-1114 HCl
CAS:CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.Fórmula:C13H14ClN3Pureza:99.53%Cor e Forma:SoildPeso molecular:247.722,4-Dichlorobenzoyl Chloride
CAS:Produto ControladoApplications 2,4-Dichlorobenzoyl Chloride is a reactant used in the synthesis of aroyl(sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mahdavi, M., et. al.: Eur. J. Med. Chem., 82, 308 (2014)Fórmula:C7H3Cl3OCor e Forma:NeatPeso molecular:209.462,5-Di-tert-butylhydroquinone
CAS:2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.Fórmula:C14H22O2Pureza:97.11%Cor e Forma:PelletslargecrystalsPeso molecular:222.321-Naphthyl 3,5-dinitrobenzoate
CAS:1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.Fórmula:C17H10N2O6Pureza:97.42%Cor e Forma:SolidPeso molecular:338.27Nordihydro Guaiaretic Acid (mixture of diastereomers)
CAS:Produto ControladoApplications Nordihydro Guaiaretic Acid is a lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, whereas Resveratrol itself had no activity and its oxidation efficiency was low. References Brash, A., et al.: J. Biol. Chem., 274, 23679 (1999), Fujimoto, A., et al.: Bioorg. Med. Chem. Lett., 20, 7393 (2010), Ridolfi, M., et al.: J. Agric. Food Chem., 50, 835 (2002),Fórmula:C18H22O4Cor e Forma:White To BrownPeso molecular:302.36MK-886
CAS:Produto ControladoApplications MK-886 is a potent and selective inhibitor of FLAP and Cox-1. References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);Fórmula:C27H34ClNO2SCor e Forma:NeatPeso molecular:472.084',5-Dihydroxyflavone
CAS:4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).Fórmula:C15H10O4Pureza:95.38%Cor e Forma:SolidPeso molecular:254.24RWJ 63556
CAS:RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.Fórmula:C11H10FNO3S2Pureza:98.91%Cor e Forma:SolidPeso molecular:287.33Ref: TM-T12784
1mg52,00€5mg93,00€10mg145,00€25mg279,00€50mg424,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)87,00€Caffeic Acid
CAS:Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplasticFórmula:C9H8O4Pureza:98.89% - 99.3%Cor e Forma:Yellow Crystals From Concentrated Aqueous Solutions Alkaline Solns Turn From Yellow To Orange Alkaline Solutions Turn From Yellow To Orange (Ntp 1992)Peso molecular:180.16Dimethyl (2-Oxoheptyl)phosphonate
CAS:Produto ControladoApplications Dimethyl (2-Oxoheptyl)phosphonate is a useful synthetic intermediate, and is used as a reagent to synthesize Caffeic acid (C080000) derivatives, which function as 5-lipoxygenase, 12-lipoxygenase, and prostaglandin synthase inhibitors. References Sugiura, M., et al.: Chem. Pharm. Bull., 37, 1039 (1989)Fórmula:C9H19O4PCor e Forma:YellowPeso molecular:222.22E 6080 HCl
CAS:E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.Fórmula:C17H20ClN3O3S2Pureza:99.59%Cor e Forma:SoildPeso molecular:413.94U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Fórmula:C29H40N2O3Pureza:97.50%Cor e Forma:Solid Off-WhitePeso molecular:464.64COX-2/15-LOX-IN-2
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.Fórmula:C27H26N6OS2Pureza:98%Cor e Forma:SolidPeso molecular:514.66Chebulagic acid
CAS:Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Fórmula:C41H30O27Pureza:100% - 99.8%Cor e Forma:SolidPeso molecular:954.66Ref: TM-TQ0180
1mg79,00€5mg165,00€10mg238,00€25mg398,00€50mg592,00€100mg842,00€1mL*10mM (DMSO)256,00€Setileuton
CAS:Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.Fórmula:C22H17F4N3O4Pureza:100% - 99.31%Cor e Forma:SolidPeso molecular:463.38Oleoyl coenzyme A lithium
CAS:Oleoyl coenzyme A lithium (Oleoyl-CoA lithium) is a thioester of oleic acid and coenzyme A, acting as an allosteric inhibitor of h15-LOX-2.Fórmula:C39H67LiN7O17P3SCor e Forma:SolidPeso molecular:1037.913-Hydroxycoumarin
CAS:3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitorsFórmula:C9H6O3Pureza:98.32% - 99.5%Cor e Forma:SolidPeso molecular:162.14
