Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Produtos da "Lipoxigenase"
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ALOX15-IN-2
CAS:ALOX15-IN-2: Potent ALOX15 inhibitor. IC50: 1.55 μM for LA; 2.79 μM for AA. Stops linoleic/arachidonic acid oxidation.Fórmula:C23H29N3O4SPureza:99.32%Cor e Forma:SolidPeso molecular:443.56Ref: TM-T62606
1mg48,00€5mg96,00€10mg169,00€25mg329,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)105,00€h15-LOX-2 inhibitor 3
CAS:Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.Fórmula:C22H13N5O3Cor e Forma:SolidPeso molecular:395.37PD-146176
CAS:Produto ControladoApplications PD-146176 is a potent and selective 15-LO inhibitor.Fórmula:C15H11NSCor e Forma:NeatPeso molecular:237.32COX-2/15-LOX-IN-3
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM,Fórmula:C25H24FN3O3SPureza:98%Cor e Forma:SolidPeso molecular:465.5411-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Ref: TM-TN1182
1mg60,00€5mg137,00€10mg210,00€25mg356,00€50mg525,00€100mg750,00€1mL*10mM (DMSO)140,00€Utreloxastat
CAS:Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis .Fórmula:C18H28O2Pureza:99.95%Cor e Forma:SolidPeso molecular:276.41Ref: TM-T60507
1mg92,00€5mg216,00€10mg311,00€25mg533,00€50mg787,00€100mg1.378,00€200mg1.853,00€1mL*10mM (DMSO)235,00€Lipoxygenase
CAS:Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.Cor e Forma:Solid4-(2-Methylpropyl)benzenemethanol
CAS:Produto ControladoFórmula:C11H16OCor e Forma:NeatPeso molecular:164.24Shogaol
CAS:6-Shogaol: anti-inflammatory, analgesic, antipyretic, protects cartilage, arrests cancer cell growth, inhibits metastasis.Fórmula:C17H24O3Pureza:98.26% - 99.39%Cor e Forma:SolidPeso molecular:276.37Ref: TM-T6S1699
2mg43,00€5mg62,00€10mg92,00€25mg180,00€50mg283,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)67,00€Enazadrem
CAS:Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.Fórmula:C18H25N3OPureza:98%Cor e Forma:SolidPeso molecular:299.41Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Fórmula:C23H22ClNO2Pureza:99.49%Cor e Forma:Yellowish SolidPeso molecular:379.88Ref: TM-T6568
5mg47,00€10mg70,00€25mg126,00€50mg187,00€100mg279,00€200mg415,00€500mg658,00€1mL*10mM (DMSO)50,00€Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Fórmula:C16H12ClNO3Pureza:99.78%Cor e Forma:SolidPeso molecular:301.72Ref: TM-T19679
1mg202,00€5mg472,00€10mg707,00€25mg1.035,00€50mg1.311,00€100mg1.663,00€1mL*10mM (DMSO)469,00€5-LOX-IN-1
CAS:5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.Fórmula:C20H18N2O2SPureza:97.45%Cor e Forma:SolidPeso molecular:350.433-O-Acetyl-11-hydroxy-β-boswellic acid
CAS:3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).Fórmula:C32H50O5Pureza:98.24%Cor e Forma:SolidPeso molecular:514.74SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Fórmula:C16H12FN3SPureza:98% - 99.68%Cor e Forma:SolidPeso molecular:297.35CAY10698
CAS:CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).Fórmula:C17H17N3O4S2Pureza:98.97%Cor e Forma:SolidPeso molecular:391.46Ref: TM-T8950
1mg48,00€2mg63,00€5mg93,00€10mg139,00€25mg274,00€50mg425,00€100mg625,00€500mg1.311,00€1mL*10mM (DMSO)97,00€Bunaprolast
CAS:Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase andFórmula:C17H20O3Pureza:99.9%Cor e Forma:SolidPeso molecular:272.34LOX-IN-5
CAS:LOX-IN-5 (compound 22) is a non-selective LOX inhibitor.Fórmula:C21H25FN4O2SCor e Forma:SolidPeso molecular:416.51CCT365623 hydrochloride
CAS:CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.Fórmula:C18H18ClNO4S3Pureza:98%Cor e Forma:SolidPeso molecular:443.99
