p97
Os inibidores de p97 são compostos que inibem p97, também conhecido como Proteína Contenedora de Valosina (VCP), uma ATPase envolvida em vários processos celulares, incluindo a degradação de proteínas, regulação do ciclo celular e reparo do DNA. p97 desempenha um papel crucial no sistema ubiquitina-proteassoma, e sua inibição é de grande interesse na pesquisa do câncer, doenças neurodegenerativas e outros distúrbios onde a homeostase proteica é perturbada. Na CymitQuimica, oferecemos inibidores de p97 para apoiar sua pesquisa em proteostasia, neurobiologia e terapia contra o câncer.
Produtos da "p97"
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15 produtos desta categoria.
CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:98.5%Cor e Forma:SoildPeso molecular:412.49ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:100% - 99.66%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T3535
1mg38,00€5mg81,00€10mg116,00€25mg205,00€50mg329,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)88,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Cor e Forma:SolidPeso molecular:408.92CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:100% - 99.92%Cor e Forma:SolidPeso molecular:413.47Ref: TM-T6796
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg298,00€50mg469,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)97,00€NSC799462
NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.Fórmula:C30H32F2N6O3SCor e Forma:SolidPeso molecular:594.68UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Cor e Forma:SolidPeso molecular:344.8UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:594.68UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SCor e Forma:SolidPeso molecular:430.86NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.5%Cor e Forma:SolidPeso molecular:520.67NSC819701
NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.Fórmula:C30H32F2N8O3SCor e Forma:SolidPeso molecular:622.69UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C23H16ClN3O3SCor e Forma:SolidPeso molecular:449.91ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Fórmula:C23H24N4OPureza:98%Cor e Forma:SolidPeso molecular:372.46DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Fórmula:C22H20N4Pureza:98.89% - ≥95%Cor e Forma:SolidPeso molecular:340.42Ref: TM-T1969
5mg58,00€10mg95,00€25mg180,00€50mg324,00€100mg410,00€200mg607,00€500mg938,00€1mL*10mM (DMSO)59,00€NPD8733
CAS:NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.Fórmula:C18H15NO4Pureza:98.48%Cor e Forma:SolidPeso molecular:309.32Ref: TM-T9008
1mg42,00€5mg87,00€10mg125,00€25mg245,00€50mg399,00€100mg645,00€500mg1.311,00€1mL*10mM (DMSO)183,00€MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Cor e Forma:SolidPeso molecular:462.55
