Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase
- Hedgehog/Smoothened
- Via Hippo
- JAK
- Porcupine
- ROCK
- STAT
- Células - tronco
- TGF-beta/Smad
- Wnt/beta-catenina
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Produtos da "Células - tronco e Derivados"
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HC-258
CAS:HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Fórmula:C20H24N2O2Cor e Forma:SolidPeso molecular:324.42STAT3-IN-8
CAS:"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."Fórmula:C19H7F7N2O3Pureza:98%Cor e Forma:SolidPeso molecular:444.26ROCK2-IN-7
CAS:ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Fórmula:C26H28FN5OPureza:98%Cor e Forma:SolidPeso molecular:445.53Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Fórmula:C19H11ClN3NaO2Pureza:99.49% - 99.62%Cor e Forma:SolidPeso molecular:371.75JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Fórmula:C26H30ClN7O2Cor e Forma:SolidPeso molecular:508.02Ac-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Fórmula:C38H60N9O14P·xC2H4O2Cor e Forma:SolidPeso molecular:897.91 (free base)WHN-88
CAS:WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.Fórmula:C18H13I2N3O2Cor e Forma:SolidPeso molecular:557.12Golotimod (TFA) (229305-39-9 free base)
Golotimod (TFA), an immunomodulating peptide, boosts antituberculosis treatments and enhances immune cell growth and macrophage function.Fórmula:C18H20F3N3O7Pureza:98%Cor e Forma:SolidPeso molecular:447.36Ritlecitinib
CAS:Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Fórmula:C15H19N5OPureza:98.82% - 99.92%Cor e Forma:SolidPeso molecular:285.34Ref: TM-T5382
2mg47,00€5mg70,00€10mg111,00€25mg216,00€50mg329,00€100mg495,00€200mg705,00€500mg1.064,00€1mL*10mM (DMSO)77,00€JLK6
CAS:JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signallingFórmula:C10H8ClNO3Pureza:96.50%Cor e Forma:SolidPeso molecular:225.63Ref: TM-T21890
1mg131,00€5mg259,00€10mg371,00€25mg622,00€50mg885,00€100mg1.206,00€500mg2.403,00€1mL*10mM (DMSO)271,00€Ruxolitinib
CAS:Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Fórmula:C17H18N6Pureza:100% - 99.99%Cor e Forma:SolidPeso molecular:306.36Ref: TM-T1829
5mg58,00€10mg74,00€25mg92,00€50mg116,00€100mg155,00€200mg245,00€500mg414,00€1mL*10mM (DMSO)65,00€STAT3-IN-36
CAS:STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.Fórmula:C30H24F2N2O9S2Cor e Forma:SolidPeso molecular:658.65TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Fórmula:C10H10N2O2SPureza:97.13% - 99.48%Cor e Forma:White SolidPeso molecular:222.26NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Fórmula:C27H28F2N6OPureza:98%Cor e Forma:SolidPeso molecular:490.55MRT-14
CAS:MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Fórmula:C24H24N4O5Pureza:98.55%Cor e Forma:SolidPeso molecular:448.47Ref: TM-T9531
2mg35,00€5mg52,00€10mg85,00€25mg138,00€50mg220,00€100mg329,00€200mg469,00€1mL*10mM (DMSO)65,00€BDP5290
CAS:BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Fórmula:C17H18ClN7OPureza:97.22%Cor e Forma:SolidPeso molecular:371.82Ref: TM-T7301
1mg56,00€2mg81,00€5mg119,00€10mg188,00€25mg389,00€50mg565,00€100mg822,00€1mL*10mM (DMSO)131,00€Casein kinase 1δ-IN-7
CAS:Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Fórmula:C17H14N4O2SPureza:98.6%Cor e Forma:SolidPeso molecular:338.38ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Fórmula:C19H22N4O3SCor e Forma:SolidPeso molecular:386.47YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Fórmula:C32H34F3N7O2Cor e Forma:SolidPeso molecular:605.65ZW4864 free base
CAS:ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.Fórmula:C33H42N6O3Pureza:99.54%Cor e Forma:SolidPeso molecular:570.72Ref: TM-T9642
1mg160,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€MGD-28
CAS:MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.Fórmula:C33H34FN7O3Pureza:99.39%Cor e Forma:SolidPeso molecular:595.67H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Fórmula:C16H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:319.42Itacitinib
CAS:Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Fórmula:C26H23F4N9OPureza:96.4% - 99.01%Cor e Forma:SolidPeso molecular:553.51Ref: TM-T3998
1mg49,00€2mg71,00€5mg111,00€10mg180,00€25mg325,00€50mg543,00€100mg780,00€500mg1.549,00€1mL*10mM (DMSO)137,00€Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Cor e Forma:SolidPeso molecular:505.5Ref: TM-T12266L
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)153,00€STAT5-IN-1
CAS:STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Fórmula:C16H11N3O3Pureza:99.44% - ≥95%Cor e Forma:SolidPeso molecular:293.28Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Fórmula:C26H46N7O12S2Pureza:97.70%Cor e Forma:SolidPeso molecular:712.26Ref: TM-TP1565L1
1mg96,00€5mg304,00€10mg454,00€25mg743,00€50mg1.035,00€100mg1.396,00€1mL*10mM (DMSO)325,00€Sonidegib
CAS:Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Cor e Forma:SolidPeso molecular:485.5(E/Z)-GSK-3β inhibitor 1
CAS:(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T9178
1mg38,00€5mg85,00€10mg126,00€25mg225,00€50mg335,00€100mg480,00€200mg652,00€1mL*10mM (DMSO)94,00€YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:100%Cor e Forma:SoildPeso molecular:328.37Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Fórmula:C23H25N5O4SPureza:98.14%Cor e Forma:SolidPeso molecular:467.54SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.77%Cor e Forma:SolidPeso molecular:526.52Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Fórmula:C30H26N2O2Cor e Forma:SolidPeso molecular:446.54SR-1277
CAS:SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor, regulating Wee1 activity at the G2/M cell-cycle interface, and antiproliferative.Fórmula:C21H19N9O3SCor e Forma:SolidPeso molecular:477.5IWP-2
CAS:IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.Fórmula:C22H18N4O2S3Pureza:96.1% - 99.49%Cor e Forma:SolidPeso molecular:466.6AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.Fórmula:C21H18FNO3Pureza:98%Cor e Forma:SolidPeso molecular:351.37ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.4Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Fórmula:C18H21N5O3Pureza:99.85%Cor e Forma:SolidPeso molecular:355.39Ref: TM-T78207
1mg52,00€5mg116,00€10mg178,00€25mg359,00€50mg533,00€100mg750,00€200mg1.064,00€1mL*10mM (DMSO)127,00€Jagged-1 (188-204)
CAS:Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Fórmula:C93H127N25O26S3Pureza:98%Cor e Forma:SolidPeso molecular:2107.4CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.04%Cor e Forma:SolidPeso molecular:457.48Ref: TM-T36196
1mg35,00€5mg81,00€10mg117,00€25mg259,00€50mg393,00€100mg620,00€200mg832,00€1mL*10mM (DMSO)81,00€Casein kinase 1δ-IN-13
CAS:Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Fórmula:C15H13N3O2SCor e Forma:SolidPeso molecular:299.35DC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.Fórmula:C19H17NO2SPureza:98.82%Cor e Forma:SoildPeso molecular:323.41SRI 37892
CAS:SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.Fórmula:C26H19N5O2SPureza:98.92%Cor e Forma:SolidPeso molecular:465.53Ref: TM-T9662
1mg378,00€5mg922,00€10mg1.225,00€25mg1.853,00€50mg2.490,00€100mg3.353,00€1mL*10mM (DMSO)1.074,00€GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Fórmula:C20H16N2O2Pureza:99.44%Cor e Forma:SoildPeso molecular:316.35Ref: TM-T64351
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)249,00€GSA-10
CAS:GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Fórmula:C26H30N2O5Pureza:≥98%Cor e Forma:SolidPeso molecular:450.53Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Fórmula:C24H28N8O2Pureza:98.06% - 99.94%Cor e Forma:SolidPeso molecular:460.53Ref: TM-T14331
1mg42,00€5mg88,00€10mg123,00€25mg188,00€50mg350,00€100mg522,00€200mg750,00€1mL*10mM (DMSO)116,00€(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97% - 98.03%Cor e Forma:SolidPeso molecular:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Fórmula:C28H30N8O2Cor e Forma:SolidPeso molecular:510.59HJC0152 free base
CAS:HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograftFórmula:C15H13Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:370.19Sonidegib diphosphate
CAS:Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo and human Smo.Cost-effective and quality-assured.Fórmula:C26H32F3N3O11P2Pureza:99.48%Cor e Forma:SolidPeso molecular:681.49Ref: TM-T15727
1g852,00€5g2.133,00€10g3.201,00€5mg50,00€10mg57,00€25mg90,00€50mg114,00€100mg188,00€1mL*10mM (DMSO)72,00€ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂,适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95Momelotinib sulfate
CAS:Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Fórmula:C23H26N6O10S2Pureza:98%Cor e Forma:SolidPeso molecular:610.62MRK-560
CAS:MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.Fórmula:C19H17ClF5NO4S2Pureza:98.87%Cor e Forma:SolidPeso molecular:517.92FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Fórmula:C18H14N2O4Pureza:100%Cor e Forma:SolidPeso molecular:322.31Ref: TM-T15363
2mg42,00€5mg60,00€10mg96,00€25mg177,00€50mg283,00€100mg454,00€200mg653,00€1mL*10mM (DMSO)95,00€JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFórmula:C22H24N6O3Pureza:98%Cor e Forma:SolidPeso molecular:420.46Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.01%Cor e Forma:SolidPeso molecular:456.92QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFórmula:C26H27N7O3Pureza:98%Cor e Forma:SolidPeso molecular:485.54GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SCor e Forma:SolidPeso molecular:312.35PI-828
CAS:PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.Fórmula:C19H18N2O3Pureza:99.39%Cor e Forma:SolidPeso molecular:322.36Ref: TM-T16528
1mg35,00€5mg78,00€10mg117,00€25mg197,00€50mg283,00€100mg386,00€200mg550,00€1mL*10mM (DMSO)55,00€SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Fórmula:C20H21N7OPureza:99.41%Cor e Forma:SolidPeso molecular:375.43CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent inhibitor of CK1, exhibiting IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a [1].Fórmula:C17H12FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:309.29Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Fórmula:C26H24N2O11P2Pureza:97.18%Cor e Forma:SolidPeso molecular:602.42YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Fórmula:C18H15FN4O3Pureza:98.61% - 99.81%Cor e Forma:SolidPeso molecular:354.34PF-06952229
CAS:PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Fórmula:C23H24ClFN4O3Pureza:99.45%Cor e Forma:SolidPeso molecular:458.91TEAD-IN-2
CAS:TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Fórmula:C16H18BrF3N2OCor e Forma:SolidPeso molecular:391.23Pyridone 6
CAS:Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Fórmula:C18H16FN3OPureza:97.10% - 98.74%Cor e Forma:SolidPeso molecular:309.34Ref: TM-T3080
1mg82,00€2mg106,00€5mg162,00€10mg221,00€25mg449,00€50mg658,00€100mg939,00€500mg1.882,00€1mL*10mM (DMSO)177,00€MRT-83
CAS:MRT-83 is a potent Smo antagonist.Fórmula:C31H30N4O5Pureza:99.92%Cor e Forma:SolidPeso molecular:538.59Ref: TM-T12109
2mg46,00€5mg64,00€10mg92,00€25mg183,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)74,00€Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Fórmula:C22H23N5O2Pureza:99.61% - 99.82%Cor e Forma:SolidPeso molecular:389.45Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Cor e Forma:SolidPeso molecular:369.42Ref: TM-T2510
1g692,00€5mg48,00€10mg55,00€25mg88,00€50mg120,00€100mg188,00€200mg284,00€500mg467,00€1mL*10mM (DMSO)50,00€Casein kinase 1δ-IN-4
CAS:"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."Fórmula:C16H12N6SPureza:98%Cor e Forma:SolidPeso molecular:320.37Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Fórmula:C21H23N5O3SPureza:98.03% - ≥95%Cor e Forma:SolidPeso molecular:425.5JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Fórmula:C17H14ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:355.78JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:96.69% - 99.15%Cor e Forma:SolidPeso molecular:344.45Ref: TM-T3042
2mg39,00€5mg57,00€10mg85,00€25mg157,00€50mg274,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)63,00€SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Cor e Forma:SolidPeso molecular:415.28P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Cor e Forma:SolidPeso molecular:1995.29Nefopam hydrochloride
CAS:Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.Fórmula:C17H20ClNOPureza:99.32% - 99.85%Cor e Forma:SolidPeso molecular:289.8Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Cor e Forma:LiquidSTAT3 HiBiT degrader 1
CAS:STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Fórmula:C58H63F4N10O14PSCor e Forma:SolidPeso molecular:1263.21JK184
CAS:JK184 is a potent Hedgehog (Hh) pathway inhibitor.Fórmula:C19H18N4OSPureza:99.09% - 99.89%Cor e Forma:SolidPeso molecular:350.44TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Fórmula:C24H24N4O3Pureza:99.4%Cor e Forma:SoildPeso molecular:416.47Ref: TM-T77660
1mg42,00€2mg52,00€5mg87,00€10mg127,00€25mg250,00€50mg373,00€100mg547,00€500mg1.159,00€Fresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:144.4 kDaTAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Fórmula:C28H31F3N4O6Pureza:98.79%Cor e Forma:SolidPeso molecular:576.56β-catenin/CBP-IN-1
CAS:β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFórmula:C33H35N6O7PPureza:98%Cor e Forma:SolidPeso molecular:658.64Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.28% - 99.91%Cor e Forma:SolidPeso molecular:436.5Ref: TM-T14960
1mg77,00€5mg169,00€10mg264,00€25mg485,00€50mg705,00€100mg938,00€1mL*10mM (DMSO)183,00€AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Fórmula:C18H16F2N6Pureza:96.02% - 98.51%Cor e Forma:SolidPeso molecular:354.36β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:98.78%Cor e Forma:SolidPeso molecular:255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€KY02111
CAS:KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Fórmula:C18H17ClN2O3SPureza:97.71%（96.56%） - 98.68%Cor e Forma:SolidPeso molecular:376.86Avagacestat
CAS:Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,Fórmula:C20H17ClF4N4O4SPureza:98.87% - 99.77%Cor e Forma:SolidPeso molecular:520.89Ref: TM-T6249
1mg63,00€5mg120,00€10mg197,00€25mg376,00€50mg547,00€100mg793,00€200mg1.064,00€1mL*10mM (DMSO)139,00€Simian OC/BGP(Osteocalcin) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian OC/BGP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian OC/BGP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian OC/BGP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian OC/BGP in the samples is then determined by comparing the OD of the samples to the standard curve.Cor e Forma:Colourless TransparentliquidWAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.Fórmula:C11H12N2O2S2Pureza:99.43%Cor e Forma:SoildPeso molecular:268.36Ref: TM-T60067
1mg84,00€5mg163,00€10mg229,00€25mg379,00€50mg568,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)155,00€GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFórmula:C20H20ClN5OSPureza:98%Cor e Forma:SolidPeso molecular:413.92Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Fórmula:C20H19D3N8O3Pureza:100% - 99.43%Cor e Forma:SolidPeso molecular:425.46Ref: TM-T14687
1mg70,00€5mg153,00€10mg274,00€25mg432,00€50mg638,00€100mg908,00€200mg1.225,00€500mg1.825,00€1mL*10mM (DMSO)166,00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€GSK-3 inhibitor 3
CAS:GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFórmula:C23H15FN6OPureza:98.36%Cor e Forma:SoildPeso molecular:410.4YAP-TEAD-IN-3
CAS:YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFórmula:C27H26ClF2N3O4Pureza:97.81% - 98.71%Cor e Forma:SoildPeso molecular:529.96GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Fórmula:C28H28ClF2N9O3Pureza:98.54%Cor e Forma:SolidPeso molecular:612.03Ref: TM-T9826
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)259,00€VT104
CAS:VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research.Cost-effective and quality-assured.Fórmula:C25H19F3N2OPureza:99.43% - 99.5%Cor e Forma:SolidPeso molecular:420.43Ref: TM-T67872
1mg79,00€5mg243,00€10mg394,00€25mg640,00€50mg898,00€100mg1.206,00€1mL*10mM (DMSO)225,00€AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Fórmula:C29H28F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:535.56RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.06% - ≥95%Cor e Forma:SolidPeso molecular:340.4A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Fórmula:C17H13F3N4O2Pureza:99.78%Cor e Forma:SolidPeso molecular:362.31
