Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase
- Hedgehog/Smoothened
- Via Hippo
- JAK
- Porcupine
- ROCK
- STAT
- Células - tronco
- TGF-beta/Smad
- Wnt/beta-catenina
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Produtos da "Células - tronco e Derivados"
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Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Cor e Forma:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)177,00€CUR61414
CAS:CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Fórmula:C31H42N4O5Pureza:97.34% - 98.00%Cor e Forma:SolidPeso molecular:550.69Ref: TM-T15019
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)123,00€LSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Fórmula:C23H43F3N6O7Pureza:99.33%Cor e Forma:SolidPeso molecular:572.62CCG 203769
CAS:CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Fórmula:C8H14N2O2SPureza:99.46%Cor e Forma:SolidPeso molecular:202.27Ref: TM-T10705
1mg88,00€5mg187,00€10mg264,00€25mg469,00€50mg657,00€100mg944,00€500mg1.882,00€1mL*10mM (DMSO)207,00€DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Fórmula:C13H17ClO4Pureza:99.57%Cor e Forma:SolidPeso molecular:272.72Ref: TM-T60485
1mg92,00€5mg235,00€10mg350,00€25mg588,00€50mg838,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)215,00€2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Fórmula:C16H13Cl2N3O2Pureza:98.77%Cor e Forma:SolidPeso molecular:350.2SAG 21k
CAS:SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Fórmula:C29H28ClF2N3O2SPureza:99.51%Cor e Forma:SolidPeso molecular:556.07BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Fórmula:C14H10BrNOSPureza:99.48% - 99.94%Cor e Forma:SolidPeso molecular:320.2Ref: TM-T7799
5mg47,00€10mg60,00€25mg88,00€50mg126,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Fórmula:C19H23ClN2O3SPureza:99.53%Cor e Forma:SoildPeso molecular:394.92JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFórmula:C19H18N4O3Pureza:97.46% - 99.94%Cor e Forma:SolidPeso molecular:350.37Cenacitinib
CAS:Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Fórmula:C19H19F2N7O3Cor e Forma:SolidPeso molecular:431.40JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Fórmula:C28H38N6O5SPureza:98%Cor e Forma:SolidPeso molecular:570.7ARN25068
CAS:ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Fórmula:C19H18N6SPureza:99.71%Cor e Forma:SolidPeso molecular:362.45ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Fórmula:C19H20BrClN2O3SPureza:99.73%Cor e Forma:SolidPeso molecular:471.8Ref: TM-T11178L
1mg162,00€5mg391,00€10mg615,00€25mg907,00€50mg1.235,00€100mg1.663,00€1mL*10mM (DMSO)447,00€JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Fórmula:C14H10ClN3OS2Pureza:99.38%Cor e Forma:SolidPeso molecular:335.83SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Cor e Forma:SolidPeso molecular:329.48Ref: TM-T4283
1mg35,00€2mg48,00€5mg70,00€10mg111,00€25mg227,00€50mg378,00€100mg622,00€200mg873,00€500mg1.293,00€1mL*10mM (DMSO)49,00€Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Fórmula:C18H16O4Pureza:99.94%Cor e Forma:SolidPeso molecular:296.32Ref: TM-T17256
2mg34,00€5mg52,00€10mg80,00€25mg131,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)52,00€Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50Ref: TM-T35898
1mg88,00€5mg187,00€10mg298,00€25mg597,00€50mg938,00€100mg1.510,00€200mg2.072,00€1mL*10mM (DMSO)207,00€NSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Fórmula:C21H25NO6Pureza:96.16%Cor e Forma:SolidPeso molecular:387.43Ref: TM-T9949
5mg70,00€10mg119,00€25mg250,00€50mg424,00€100mg627,00€500mg1.320,00€1mL*10mM (DMSO)77,00€JNJ-1289
CAS:JNJ-1289: potent hSMOX inhibitor, IC50 50 nM, potential for anticancer/anti-inflammatory research.Fórmula:C16H12N4OSPureza:98.16%Cor e Forma:SolidPeso molecular:308.36
