Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase
- Hedgehog/Smoothened
- Via Hippo
- JAK
- Porcupine
- ROCK
- STAT
- Células - tronco
- TGF-beta/Smad
- Wnt/beta-catenina
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Produtos da "Células - tronco e Derivados"
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Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Fórmula:C23H22N6O2Pureza:97.47% - 99.56%Cor e Forma:SolidPeso molecular:414.46Ref: TM-T1849
1mg38,00€2mg49,00€5mg81,00€10mg95,00€25mg166,00€50mg259,00€100mg406,00€200mg625,00€1mL*10mM (DMSO)88,00€GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:98.8%Cor e Forma:SolidPeso molecular:313.42Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:SolidPeso molecular:452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:97.10% - 98.54%Cor e Forma:SolidPeso molecular:358.18Ref: TM-T3156
2mg42,00€5mg59,00€10mg85,00€25mg168,00€50mg235,00€100mg331,00€200mg492,00€1mL*10mM (DMSO)69,00€GNE-7883
CAS:GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Fórmula:C28H29FN6O2Pureza:97.61%Cor e Forma:SolidPeso molecular:500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€Aβ-IN-1
CAS:Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C35H49NPureza:99.14%Cor e Forma:SoildPeso molecular:483.77Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Cor e Forma:LiquidRuxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Fórmula:C17H18N6Pureza:99.37% - 99.79%Cor e Forma:SolidPeso molecular:306.36CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:98.34% - 99.01%Cor e Forma:SolidPeso molecular:466.46JAK2-IN-9
CAS:Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.Fórmula:C20H24N6O2SPureza:98%Cor e Forma:SolidPeso molecular:412.51YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Fórmula:C25H24ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:470.92ROCK-IN-6
CAS:ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1Fórmula:C19H19N5O8SPureza:98%Cor e Forma:SolidPeso molecular:477.45WAY-656935
CAS:WAY-656935 inhibits ROCK.Fórmula:C20H28ClN3O3SPureza:98.1%Cor e Forma:SolidPeso molecular:425.97Amcasertib
CAS:Amcasertib (BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways via targeting stemness kinases.Fórmula:C31H33N5O2SPureza:100% - 99.31%Cor e Forma:SolidPeso molecular:539.69Zelasudil
CAS:Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.Fórmula:C22H21F2N7OPureza:99.15%Cor e Forma:SolidPeso molecular:437.445Ref: TM-T69665
1mg92,00€5mg180,00€10mg274,00€25mg469,00€50mg653,00€100mg912,00€200mg1.225,00€1mL*10mM (DMSO)188,00€Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.51%Cor e Forma:SolidPeso molecular:352.5Ref: TM-T12721
1mg74,00€5mg145,00€10mg215,00€25mg378,00€50mg530,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)111,00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Cor e Forma:Yellow SolidPeso molecular:294.3ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Cor e Forma:SolidPeso molecular:402.79Ref: TM-TQ0110
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€1mL*10mM (DMSO)373,00€SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Cor e Forma:SolidPeso molecular:286.29Ref: TM-T6989
5mg40,00€10mg60,00€25mg107,00€50mg185,00€100mg339,00€200mg510,00€500mg797,00€1mL*10mM (DMSO)66,00€RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Fórmula:C16H14N4O2SPureza:98% - 99.73%Cor e Forma:SolidPeso molecular:326.37Ref: TM-T1898
5mg51,00€10mg87,00€25mg187,00€50mg311,00€100mg414,00€200mg520,00€500mg840,00€1mL*10mM (DMSO)57,00€
