Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase
- Hedgehog/Smoothened
- Via Hippo
- JAK
- Porcupine
- ROCK
- STAT
- Células - tronco
- TGF-beta/Smad
- Wnt/beta-catenina
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Produtos da "Células - tronco e Derivados"
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SAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Fórmula:C28H30Cl3N3OSPureza:100%Cor e Forma:SoildPeso molecular:562.984-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:99.56%Cor e Forma:White To Beige SolidPeso molecular:233.49exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFórmula:C25H19N3O3Pureza:97.41%Cor e Forma:SolidPeso molecular:409.44Ref: TM-T22775
5mg34,00€10mg52,00€25mg105,00€50mg173,00€100mg279,00€200mg406,00€1mL*10mM (DMSO)44,00€JAK2-IN-11
CAS:JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Fórmula:C31H31F3N8O4Cor e Forma:SolidPeso molecular:639.64ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Fórmula:C18H14N4OSPureza:98.53%Cor e Forma:SolidPeso molecular:334.39Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Fórmula:C95H128F3N25O28S3Pureza:99.48%Cor e Forma:SolidPeso molecular:2221.37Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Cor e Forma:SolidPeso molecular:754.83TTP 22
CAS:TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.Fórmula:C16H14N2O2S2Pureza:97.08% - 97.78%Cor e Forma:SolidPeso molecular:330.42Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.82%Cor e Forma:SolidPeso molecular:334.39Ref: TM-T9053
1mg73,00€5mg145,00€10mg220,00€25mg437,00€50mg567,00€100mg805,00€200mg1.111,00€1mL*10mM (DMSO)161,00€Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Fórmula:C28H26N2O12P2Pureza:98.97%Cor e Forma:SolidPeso molecular:644.46Ref: TM-T9646
1mg208,00€5mg518,00€10mg740,00€25mg1.093,00€50mg1.473,00€100mg2.015,00€1mL*10mM (DMSO)737,00€Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Fórmula:C27H36N6O3SPureza:98.23% - 99.96%Cor e Forma:SolidPeso molecular:524.68Ref: TM-T1995
1g625,00€5mg49,00€10mg69,00€50mg113,00€100mg134,00€200mg216,00€500mg472,00€1mL*10mM (DMSO)57,00€Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Cor e Forma:SolidPeso molecular:291.37Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Fórmula:C24H25N7O2Cor e Forma:SolidPeso molecular:443.50Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Fórmula:C18H21F2N7OPureza:99.8%Cor e Forma:SolidPeso molecular:389.4Ref: TM-TQ0010
1mg35,00€5mg74,00€10mg110,00€25mg226,00€50mg411,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)81,00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Fórmula:C14H5F6N5OPureza:98.85% - ≥98%Cor e Forma:SolidPeso molecular:373.21Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:100% - 99.79%Cor e Forma:SolidPeso molecular:371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Fórmula:C16H18O4Pureza:98.66% - 99.48%Cor e Forma:SolidPeso molecular:274.31Ref: TM-TL0008
1mg49,00€2mg65,00€5mg97,00€10mg156,00€25mg255,00€50mg373,00€100mg555,00€1mL*10mM (DMSO)165,00€SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Fórmula:C14H14ClFN2O2Pureza:99.83%Cor e Forma:SolidPeso molecular:296.72Ref: TM-T60644
1mg52,00€5mg97,00€10mg149,00€25mg283,00€50mg550,00€100mg792,00€500mg1.605,00€1mL*10mM (DMSO)96,00€JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Fórmula:C14H18ClN3O3SPureza:99.82%Cor e Forma:SolidPeso molecular:343.83Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Fórmula:C27H41NO2Pureza:98.31% - 99.66%Cor e Forma:White Crystalline SolidPeso molecular:411.62BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.75%Cor e Forma:SolidPeso molecular:347.45HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFórmula:C24H23ClN4O3Pureza:95.73%Cor e Forma:SolidPeso molecular:450.92Ref: TM-T3460
1mg52,00€5mg97,00€10mg178,00€25mg379,00€50mg645,00€100mg1.026,00€1mL*10mM (DMSO)110,00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Fórmula:C24H40O2Pureza:99.89%Cor e Forma:SoildPeso molecular:360.57
