Wnt/beta-catenina
Os inibidores de Wnt/beta-catenina são compostos que visam e inibem a via de sinalização Wnt/beta-catenina, crucial para a regulação do desenvolvimento embrionário, proliferação celular e manutenção das células-tronco. A desregulação desta via está ligada a vários tipos de câncer e doenças degenerativas. Os inibidores da sinalização Wnt/beta-catenina são valiosos em pesquisas focadas em entender o papel dessa via na doença e no desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos inibidores de Wnt/beta-catenina para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e pesquisa oncológica.
Produtos da "Wnt/beta-catenina"
Ordenar por
BML-284 hydrochloride
CAS:BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.Fórmula:C19H19ClN4O3Pureza:99.80%Cor e Forma:SolidPeso molecular:386.84Ref: TM-T8820
1mg35,00€5mg67,00€10mg88,00€25mg150,00€50mg266,00€100mg462,00€200mg648,00€500mg1.017,00€1mL*10mM (DMSO)89,00€Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Fórmula:C25H21N3OPureza:99.56% - 99.95%Cor e Forma:SolidPeso molecular:379.45TNIK-IN-2
CAS:TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.Fórmula:C22H19N3O3Pureza:98.09%Cor e Forma:SolidPeso molecular:373.4Hematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Fórmula:C16H12O6Pureza:98%Cor e Forma:Dark Brown Crystalline PowderPeso molecular:300.26ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:98.65%Cor e Forma:SoildPeso molecular:456.88Ref: TM-T23602
1mg172,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)354,00€Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Cor e Forma:LiquidPeso molecular:145.5 kDaHLY78
CAS:HLY78, a Wnt/β-catenin activator, enhances Axin-LRP6 binding by targeting Axin's DIX domain.Fórmula:C17H17NO2Pureza:99.58%Cor e Forma:SolidPeso molecular:267.32JW 67
CAS:JW 67 is an inhibitor of canonical Wnt pathway signaling.Fórmula:C21H18N2O6Pureza:97.02%Cor e Forma:SolidPeso molecular:394.38Ref: TM-T22884
1mg46,00€2mg59,00€5mg87,00€10mg137,00€25mg273,00€50mg439,00€100mg647,00€1mL*10mM (DMSO)97,00€IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Fórmula:C22H17FN4O2S3Pureza:98.38%Cor e Forma:SolidPeso molecular:484.59Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFórmula:C25H26N6O2Pureza:97.21%Cor e Forma:SolidPeso molecular:442.51TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.75%Cor e Forma:SolidPeso molecular:371.39FH535
CAS:FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Cor e Forma:SolidPeso molecular:361.2Ref: TM-T2413
5mg38,00€10mg57,00€25mg94,00€50mg164,00€100mg274,00€200mg404,00€500mg653,00€1mL*10mM (DMSO)64,00€Miclxin
CAS:Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potentFórmula:C26H27N5O2Pureza:100% - 99.57%Cor e Forma:SolidPeso molecular:441.52Ref: TM-T73415
1mg64,00€5mg140,00€10mg192,00€25mg324,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)156,00€FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€Toxoflavin
CAS:Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.Fórmula:C7H7N5O2Pureza:98.24% - 99.7%Cor e Forma:SolidPeso molecular:193.16Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.Fórmula:C16H15ClN4O2Pureza:99.39%Cor e Forma:SolidPeso molecular:330.77Ref: TM-T9988
5mg74,00€10mg107,00€25mg216,00€50mg354,00€100mg567,00€200mg800,00€500mg1.198,00€1mL*10mM (DMSO)81,00€PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.Fórmula:C33H35N6O7PPureza:98.25% - 99.11%Cor e Forma:SoildPeso molecular:658.641(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.46Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Fórmula:C16H15FN4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:314.31Ref: TM-T60803
1mg35,00€5mg70,00€10mg103,00€25mg182,00€50mg311,00€100mg512,00€200mg720,00€1mL*10mM (DMSO)81,00€IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Fórmula:C25H19N3O3Pureza:98.46% - 99.82%Cor e Forma:SolidPeso molecular:409.44
