Wnt/beta-catenina
Os inibidores de Wnt/beta-catenina são compostos que visam e inibem a via de sinalização Wnt/beta-catenina, crucial para a regulação do desenvolvimento embrionário, proliferação celular e manutenção das células-tronco. A desregulação desta via está ligada a vários tipos de câncer e doenças degenerativas. Os inibidores da sinalização Wnt/beta-catenina são valiosos em pesquisas focadas em entender o papel dessa via na doença e no desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos inibidores de Wnt/beta-catenina para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e pesquisa oncológica.
Produtos da "Wnt/beta-catenina"
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Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Cor e Forma:LiquidSKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Cor e Forma:SolidPeso molecular:286.29Ref: TM-T6989
5mg40,00€10mg60,00€25mg107,00€50mg185,00€100mg339,00€200mg510,00€500mg797,00€1mL*10mM (DMSO)66,00€KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Fórmula:C14H10N4O3SPureza:99.66%Cor e Forma:SolidPeso molecular:314.32Ref: TM-T15677
2mg46,00€5mg80,00€10mg117,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)73,00€NRX-252262
CAS:NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)Fórmula:C23H17Cl2F3N2O4SPureza:99.10% - 99.87%Cor e Forma:SolidPeso molecular:545.36Ref: TM-T9182
1mg114,00€5mg273,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)329,00€MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Fórmula:C15H15NO4SPureza:99.76%Cor e Forma:SolidPeso molecular:305.35Ref: TM-T8710
1mg37,00€2mg49,00€5mg73,00€10mg119,00€25mg235,00€50mg354,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)82,00€LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Fórmula:C11H9ClN2O2S2Pureza:99.91%Cor e Forma:SolidPeso molecular:300.78DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Fórmula:C16H8ClF6N3OPureza:98.15%Cor e Forma:SolidPeso molecular:407.7NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Fórmula:C22H12Cl2F3N3O2SPureza:98.26%Cor e Forma:SolidPeso molecular:510.32Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Fórmula:C16H18O4Pureza:98.66% - 99.48%Cor e Forma:SolidPeso molecular:274.31Ref: TM-TL0008
1mg49,00€2mg65,00€5mg97,00€10mg156,00€25mg255,00€50mg373,00€100mg555,00€1mL*10mM (DMSO)165,00€Pamidronic acid
CAS:Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem CellsFórmula:C3H11NO7P2Pureza:97.72%Cor e Forma:SolidPeso molecular:235.07Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Fórmula:C17H15NO4Pureza:98.28%Cor e Forma:SolidPeso molecular:297.31Ref: TM-T13345
1mg49,00€5mg105,00€10mg169,00€25mg344,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)116,00€JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Fórmula:C24H20N6O2SPureza:95.00%Cor e Forma:SolidPeso molecular:456.52BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Fórmula:C19H18N4O3Pureza:99.66% - 99.91%Cor e Forma:SolidPeso molecular:350.37Ref: TM-T3144
5mg60,00€10mg88,00€25mg140,00€50mg253,00€100mg427,00€200mg615,00€500mg938,00€1mL*10mM (DMSO)66,00€WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Fórmula:C20H22N4Pureza:98.09% - 99.09%Cor e Forma:SolidPeso molecular:318.42Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.Fórmula:C29H24FN7OPureza:98.27% - 98.6%Cor e Forma:SolidPeso molecular:505.55CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Fórmula:C23H20BrN3OPureza:98.61%Cor e Forma:SolidPeso molecular:434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Fórmula:C23H20N4O3S3Pureza:100.00%Cor e Forma:SolidPeso molecular:496.62Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Fórmula:C13H17ClN4O2Pureza:99.89% - 99.94%Cor e Forma:SolidPeso molecular:296.75TNIK-IN-7
CAS:TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cellsFórmula:C23H22N4O2Pureza:99.87%Cor e Forma:SoildPeso molecular:386.45Tankyrase-IN-2
CAS:Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFórmula:C17H14F2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.3BML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Fórmula:C22H18N2O4Cor e Forma:SolidPeso molecular:374.39Carboxylesterase-IN-2
CAS:Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.Fórmula:C13H12N4OSPureza:100%Cor e Forma:SoildPeso molecular:272.33Ref: TM-T77524
1mg62,00€5mg140,00€10mg215,00€25mg369,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)156,00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Cor e Forma:SolidPeso molecular:432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Wnt pathway inhibitor 3
CAS:Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFórmula:C21H17BrN2O5Pureza:99.69%Cor e Forma:SoildPeso molecular:457.27NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Fórmula:C22H16Cl2F3N3O3SPureza:99.16% - 99.60%Cor e Forma:SolidPeso molecular:530.35Ref: TM-T63730
1mg150,00€5mg364,00€10mg588,00€25mg1.169,00€50mg1.882,00€100mg2.822,00€1mL*10mM (DMSO)426,00€KY-05009
CAS:KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Fórmula:C18H16N4O2SPureza:98.06%Cor e Forma:SolidPeso molecular:352.41Ref: TM-T11793
5mg50,00€10mg71,00€25mg117,00€50mg170,00€100mg245,00€200mg354,00€1mL*10mM (DMSO)51,00€CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.2% - 98.69%Cor e Forma:SolidPeso molecular:421.92β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Fórmula:C19H23ClN2O3SPureza:99.53%Cor e Forma:SoildPeso molecular:394.92ETC-159
CAS:ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Fórmula:C19H17N7O3Pureza:96.87% - 99.30%Cor e Forma:SolidPeso molecular:391.38Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Fórmula:C18H16O4Pureza:99.94%Cor e Forma:SolidPeso molecular:296.32Ref: TM-T17256
2mg34,00€5mg52,00€10mg80,00€25mg131,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)52,00€Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:>95% - >95%Cor e Forma:Liquid
