Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Produtos da "Células - tronco"
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JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Fórmula:C27H41NO2Pureza:98.31% - 99.66%Cor e Forma:White Crystalline SolidPeso molecular:411.62BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.75%Cor e Forma:SolidPeso molecular:347.45Casein kinase 1δ-IN-4
CAS:"Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1]."Fórmula:C16H12N6SPureza:98%Cor e Forma:SolidPeso molecular:320.37JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:96.69% - 99.15%Cor e Forma:SolidPeso molecular:344.45Ref: TM-T3042
2mg39,00€5mg57,00€10mg85,00€25mg157,00€50mg274,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)63,00€5β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.Fórmula:C24H40O2Pureza:99.89%Cor e Forma:SoildPeso molecular:360.57SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Cor e Forma:SolidPeso molecular:415.28P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Cor e Forma:SolidPeso molecular:1995.29Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Cor e Forma:LiquidDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.34 kDaDPP
CAS:DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstratingFórmula:C36H40Cl2N2O10PtPureza:98%Cor e Forma:SolidPeso molecular:926.7BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Fórmula:C26H26F4N4O3Cor e Forma:SolidPeso molecular:518.5Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Cor e Forma:LiquidAJI-100
CAS:AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Fórmula:C17H14FN5OCor e Forma:SolidPeso molecular:323.32TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:≥98%Cor e Forma:SolidPeso molecular:526.51CSNK2-IN-2
CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.Fórmula:C25H30FN9OCor e Forma:SolidPeso molecular:491.56Casein kinase 1δ-IN-3
CAS:Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.Fórmula:C17H16N2O2SPureza:99.42%Cor e Forma:SoildPeso molecular:312.39Ref: TM-T64350
1mg38,00€5mg73,00€10mg115,00€25mg235,00€50mg373,00€100mg560,00€200mg797,00€1mL*10mM (DMSO)87,00€H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:98.42%Cor e Forma:SolidPeso molecular:392.34Ref: TM-T35328
1mg64,00€5mg142,00€10mg227,00€25mg439,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)156,00€MSC-5046
MSC-5046 is a selective inhibitor of TEAD1.Fórmula:C24H18F3N5O3Cor e Forma:SolidPeso molecular:481.43WAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.Fórmula:C11H12N2O2S2Pureza:99.43%Cor e Forma:SoildPeso molecular:268.36Ref: TM-T60067
1mg84,00€5mg163,00€10mg229,00€25mg379,00€50mg568,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)155,00€
