Receptor TrK
Os inibidores dos receptores Trk têm como alvo as quinases receptoras da tropomiosina (Trk), uma família de tirosina quinases receptoras que desempenham um papel significativo no desenvolvimento e função do sistema nervoso. Os receptores Trk estão envolvidos na sinalização de neurotrofinas, essencial para a sobrevivência, diferenciação e crescimento dos neurônios. A desregulação da sinalização Trk está associada a distúrbios neurológicos e certos tipos de câncer. Na CymitQuimica, oferecemos inibidores dos receptores Trk para apoiar sua pesquisa em neurobiologia, oncologia e doenças neurodegenerativas.
Produtos da "Receptor TrK"
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TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Fórmula:C29H31F3N8OPureza:98%Cor e Forma:SolidPeso molecular:564.6BNN-20
CAS:BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Fórmula:C20H30O2Cor e Forma:SolidPeso molecular:302.45Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Cor e Forma:SolidPeso molecular:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Fórmula:C29H35F2N7O6SPureza:98%Cor e Forma:SolidPeso molecular:647.69Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFórmula:C33H29F2N5O4SPureza:98.9% - 99.74%Cor e Forma:SolidPeso molecular:629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Fórmula:C28H21F4N5O2Pureza:96.17% - 99.29%Cor e Forma:SolidPeso molecular:535.49Ref: TM-T6097
5mg50,00€10mg85,00€25mg124,00€50mg188,00€100mg311,00€200mg404,00€500mg657,00€1mL*10mM (DMSO)56,00€ALE-0540
CAS:ALE-0540: nonpeptidic heterocycle, blocks NGF binding to p75/TrkA and TrkA-mediated signaling.Fórmula:C14H11N3O5Pureza:97.25%Cor e Forma:SolidPeso molecular:301.25Ref: TM-T9292
2mg35,00€5mg55,00€10mg88,00€25mg133,00€50mg188,00€100mg269,00€200mg369,00€1mL*10mM (DMSO)60,00€TrkB-IN-1
CAS:TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.Fórmula:C19H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:368.34Type II TRK inhibitor 1
CAS:Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Fórmula:C35H33F3N8O3Pureza:98%Cor e Forma:SolidPeso molecular:670.68TrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Fórmula:C25H20N4OPureza:98%Cor e Forma:SolidPeso molecular:392.45Protein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Fórmula:C29H31F2N7OPureza:98%Cor e Forma:SolidPeso molecular:531.6CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Fórmula:C32H31N3O5SPureza:99.92%Cor e Forma:SolidPeso molecular:569.67Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Fórmula:C20H21FN6OPureza:99.55% - ≥95%Cor e Forma:SolidPeso molecular:380.42PF-06273340
CAS:PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Fórmula:C23H22ClN7O3Pureza:98% - 98.00%Cor e Forma:SolidPeso molecular:479.92ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Fórmula:C26H40N4O5Pureza:99.16% - 99.16%Cor e Forma:SolidPeso molecular:488.62ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFórmula:C32H26N4O6Pureza:98.74%Cor e Forma:SolidPeso molecular:562.57ANA-12
CAS:ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.Fórmula:C22H21N3O3SPureza:99.28% - 99.87%Cor e Forma:SolidPeso molecular:407.49NMS-P626
CAS:NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.Fórmula:C28H35F2N7O4SCor e Forma:SolidPeso molecular:603.68Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Fórmula:C21H22F2N6O2Pureza:100% - 99.15%Cor e Forma:SolidPeso molecular:428.44Ref: TM-T5995
1mg39,00€5mg79,00€10mg96,00€25mg165,00€50mg250,00€100mg376,00€500mg867,00€1mL*10mM (DMSO)86,00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Fórmula:C27H33ClN2O4Pureza:98.18%Cor e Forma:SolidPeso molecular:485.01
