FLT
Os inibidores de FLT (Fms-like tyrosine kinase) são compostos que têm como alvo os receptores FLT, que estão envolvidos na regulação da angiogênese através da via do VEGF (fator de crescimento endotelial vascular). Os receptores FLT desempenham um papel crucial no desenvolvimento de novos vasos sanguíneos em tumores. Inibir os receptores FLT pode reduzir efetivamente a angiogênese e o crescimento tumoral, tornando esses inibidores importantes na terapia contra o câncer. Na CymitQuimica, oferecemos uma seleção de inibidores de FLT de alta qualidade para apoiar sua pesquisa em oncologia, biologia vascular e angiogênese.
Produtos da "FLT"
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58 produtos desta categoria.
FLT3-IN-2
CAS:FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).Fórmula:C21H16ClF3N4Pureza:97.57% - 98.53%Cor e Forma:SolidPeso molecular:416.83Ref: TM-T1938
1mg43,00€2mg56,00€5mg87,00€10mg119,00€25mg210,00€50mg350,00€100mg505,00€1mL*10mM (DMSO)87,00€5'-Fluoroindirubinoxime
CAS:5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).Fórmula:C16H10FN3O2Pureza:100%Cor e Forma:SolidPeso molecular:295.27UNC2025 2HCl (1429881-91-3(free base))
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.Fórmula:C28H42Cl2N6OPureza:99.71%Cor e Forma:SolidPeso molecular:549.62Gilteritinib hemifumarate
CAS:Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment ofFórmula:C29H44N8O3C4H4O4Pureza:98.07%Cor e Forma:SolidPeso molecular:610.75Dapolsertib
CAS:Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.Fórmula:C15H18Br2N4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:446.14FLT3-IN-3
CAS:FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Fórmula:C27H38N8OPureza:99.25%Cor e Forma:SolidPeso molecular:490.64Ref: TM-T11298
1mg107,00€5mg259,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€500mg2.717,00€1mL*10mM (DMSO)278,00€SB1317 hydrochloride (1204918-72-8(free base))
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).Fórmula:C23H25ClN4OPureza:99.84%Cor e Forma:SolidPeso molecular:408.92Ref: TM-T4227
1mg49,00€2mg69,00€5mg113,00€10mg180,00€25mg324,00€50mg393,00€100mg585,00€1mL*10mM (DMSO)124,00€BPR1J-097 hydrochloride (1327167-19-0(free base))
BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.Fórmula:C27H29ClN6O3SPureza:98% - 98.54%Cor e Forma:SolidPeso molecular:553.07UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Fórmula:C24H34FN7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:471.57HM43239
CAS:HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.Fórmula:C29H33ClN6Pureza:98.56%Cor e Forma:SolidPeso molecular:501.07TG-46
CAS:TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Fórmula:C26H34N6O3SPureza:100% - 99.87%Cor e Forma:SolidPeso molecular:510.65BPR1K871
CAS:BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values ofFórmula:C25H28ClN7O2SCor e Forma:SolidPeso molecular:526.05AXL-IN-13
CAS:AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Fórmula:C34H41FN6O5Pureza:99.38%Cor e Forma:SolidPeso molecular:632.72Gilteritinib
CAS:Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,Fórmula:C29H44N8O3Pureza:97.75% - 99.74%Cor e Forma:SolidPeso molecular:552.71Ref: TM-T4409
1g1.359,00€1mg40,00€2mg55,00€5mg89,00€10mg120,00€25mg187,00€50mg276,00€100mg434,00€500mg1.008,00€TAS05567
CAS:TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).Fórmula:C21H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:439.51Anti-FLT1 Antibody (6S618)
Anti-FLT1 Antibody (6S618) is an antibody targeting FLT1. Anti-FLT1 Antibody (6S618) can be used in ELISA, IHC.Cor e Forma:Odour LiquidTCS 359
CAS:TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.Fórmula:C18H20N2O4SPureza:99.31%Cor e Forma:SolidPeso molecular:360.43HPK1-IN-2
CAS:HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.Fórmula:C19H20N6OSPureza:97.31%Cor e Forma:SolidPeso molecular:380.47Ref: TM-T9017
1mg78,00€5mg143,00€10mg230,00€25mg385,00€50mg548,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)170,00€Flonoltinib
CAS:Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.Fórmula:C25H34FN7OPureza:99.52%Cor e Forma:SolidPeso molecular:467.58FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor of the FLT3-ITD kinase, exhibiting an IC50 of 2.12 nM. It effectively suppresses the proliferation of the FLT3-dependent human AML cell line MOLM-13, with an IC50 of 25.65 nM. FLT3-ITD-IN-2 demonstrates antitumor activity against acute myeloid leukemia.Fórmula:C39H50N8O6Cor e Forma:SolidPeso molecular:726.86NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFórmula:C27H29N5OPureza:96.03% - 99.55%Cor e Forma:SolidPeso molecular:439.55VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.UNC2025
CAS:UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.Fórmula:C28H40N6OPureza:99.53% - 99.74%Cor e Forma:SolidPeso molecular:476.66TG-89
CAS:TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian andFórmula:C26H34N6O3SPureza:98.8%Cor e Forma:SolidPeso molecular:510.65FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:85.45 kDa (predicted); 113.32 kDa (reducing conditions)SGI-7079
CAS:SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.Fórmula:C26H26FN7Pureza:95.05% - 99.26%Cor e Forma:SolidPeso molecular:455.53Ref: TM-T6982
2mg42,00€5mg62,00€10mg97,00€25mg188,00€50mg243,00€100mg354,00€500mg825,00€1mL*10mM (DMSO)67,00€4SC-203
CAS:4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.Fórmula:C33H38N8O4SPureza:96.4% - 99.73%Cor e Forma:SolidPeso molecular:642.77Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Fórmula:C26H29N5O2Pureza:97.45% - 99.28%Cor e Forma:SolidPeso molecular:443.54FLT3-IN-4
CAS:FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenousFórmula:C23H25N7O2Pureza:98.96%Cor e Forma:SolidPeso molecular:431.49Ref: TM-T11299
1mg93,00€5mg226,00€10mg335,00€25mg538,00€50mg730,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)249,00€Crotonoside
CAS:Crotonoside (Isoguanosine) is a natural product, which inhibits FLT3 and HDAC3/6 and has research potential for the treatment of acute myeloid leukaemia (AML).Fórmula:C10H13N5O5Pureza:100% - 99.51%Cor e Forma:SolidPeso molecular:283.24Ref: TM-T6S0033
5mg35,00€10mg51,00€25mg95,00€50mg131,00€100mg200,00€200mg281,00€1mL*10mM (DMSO)35,00€FLT3-IN-10
CAS:FLT3-IN-10, a potent FLT3 inhibitor, may treat FLT3-mutated AML.Fórmula:C15H11FN2OPureza:99.60%Cor e Forma:SolidPeso molecular:254.26Ref: TM-T9856
1mg38,00€5mg85,00€10mg131,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)81,00€CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.88%Cor e Forma:SolidPeso molecular:456.37Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Cor e Forma:SolidPeso molecular:472.58Anti-FLT1 Antibody (6K171)
Anti-FLT1 Antibody (6K171) is a Mouse antibody targeting FLT1. Anti-FLT1 Antibody (6K171) can be used in ELISA,ICC/IF.Cor e Forma:Odour LiquidAnti-FLT1 Antibody (3W705)
Anti-FLT1 Antibody (3W705) is an antibody targeting FLT1. Anti-FLT1 Antibody (3W705) can be used in ELISA, WB, IHC, FCM.Cor e Forma:Odour LiquidJI6
CAS:JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor.Fórmula:C19H17N3O4SPureza:97.74%Cor e Forma:SoildPeso molecular:383.42AC710
CAS:AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Fórmula:C31H42N6O4Pureza:99.48%Cor e Forma:SolidPeso molecular:562.7Anti-VEGFR1/FLT-1 Antibody (9F18)
Anti-VEGFR1/FLT-1 Antibody (9F18) is a Rabbit antibody targeting VEGFR1/FLT-1. Anti-VEGFR1/FLT-1 Antibody (9F18) can be used in ELISA.Cor e Forma:Odour LiquidBPR1J-097
CAS:BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).Fórmula:C27H28N6O3SPureza:99.3%Cor e Forma:SolidPeso molecular:516.61Merestinib dihydrochloride
CAS:Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.Fórmula:C30H24Cl2F2N6O3Cor e Forma:SolidPeso molecular:625.45JTV-519 free base
CAS:JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmicFórmula:C25H32N2O2SPureza:98%Cor e Forma:SolidPeso molecular:424.6MRX-2843
CAS:MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Fórmula:C29H40N6OPureza:99.63%Cor e Forma:SolidPeso molecular:488.67Ref: TM-T16144
1mg65,00€5mg144,00€10mg227,00€25mg454,00€50mg655,00€100mg933,00€1mL*10mM (DMSO)157,00€Fostamatinib Disodium
CAS:Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Fórmula:C23H24FN6O9P·2NaPureza:96.13% - 98.95%Cor e Forma:SolidPeso molecular:624.42Ref: TM-T2605
1mg47,00€2mg55,00€5mg88,00€10mg124,00€25mg221,00€50mg374,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)116,00€3-Hydroxy Midostaurin
CAS:3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFórmula:C35H30N4O5Pureza:98%Cor e Forma:SolidPeso molecular:586.648OTS447
CAS:OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Fórmula:C27H32ClN3O2Pureza:97.72%Cor e Forma:SolidPeso molecular:466.027BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.Fórmula:C16H10BrN3O2Pureza:99.77%Cor e Forma:SolidPeso molecular:356.17Ref: TM-T22012
5mg46,00€10mg64,00€25mg116,00€50mg178,00€100mg284,00€200mg401,00€1mL*10mM (DMSO)52,00€Fostamatinib
CAS:Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.Fórmula:C23H26FN6O9PPureza:93.08% - 99.38%Cor e Forma:SolidPeso molecular:580.46Ref: TM-T6115
1mg43,00€2mg57,00€5mg88,00€10mg118,00€25mg210,00€50mg335,00€100mg548,00€500mg1.198,00€1mL*10mM (DMSO)101,00€FN-1501
CAS:FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Fórmula:C22H25N9OPureza:96.35%Cor e Forma:SolidPeso molecular:431.49Ref: TM-T15335
1mg92,00€5mg187,00€10mg311,00€25mg567,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)215,00€JAK3-IN-14
CAS:JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.Fórmula:C18H13N3OPureza:98.98%Cor e Forma:SoildPeso molecular:287.32Ref: TM-T67754
1mg215,00€5mg620,00€10mg904,00€25mg1.320,00€50mg1.786,00€100mg2.432,00€1mL*10mM (DMSO)540,00€FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:83.7 kDa (predicted); 110-120 kDa (reducing condition, due to glycosylation)VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.GTP-14564
CAS:GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Fórmula:C15H10N2OPureza:99.69%Cor e Forma:SolidPeso molecular:234.25AMG 925
CAS:AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Fórmula:C26H29N7O2Pureza:99.75%Cor e Forma:SolidPeso molecular:471.55(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97% - 98.03%Cor e Forma:SolidPeso molecular:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€SKLB4771
CAS:SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Fórmula:C25H27N7O3S2Pureza:100% - 98.27%Cor e Forma:SolidPeso molecular:537.66Ref: TM-T2051
1mg66,00€2mg87,00€5mg131,00€10mg187,00€25mg393,00€50mg587,00€100mg835,00€500mg1.700,00€1mL*10mM (DMSO)157,00€FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag.Pureza:97.5%Cor e Forma:Lyophilized PowderPeso molecular:35.6 kDa (predicted)AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.Fórmula:C17H14N6Pureza:97.3%Cor e Forma:SolidPeso molecular:302.33FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:61.1 kDa (predicted)
