c-Kit
Os inibidores de c-Kit são compostos que bloqueiam a atividade do Receptor do Fator de Células-Tronco (c-Kit), uma tirosina quinase que desempenha um papel crucial na sobrevivência, proliferação e diferenciação celular, particularmente em células hematopoéticas. As mutações em c-Kit estão ligadas a vários tipos de câncer, incluindo tumores estromais gastrointestinais (GIST) e leucemia. Na CymitQuimica, oferecemos inibidores de c-Kit para apoiar sua pesquisa em oncologia, hematologia e biologia de células-tronco.
Produtos da "c-Kit"
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AC710
CAS:AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Fórmula:C31H42N6O4Pureza:99.48%Cor e Forma:SolidPeso molecular:562.7Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFórmula:C33H29F2N5O4SPureza:98.9% - 99.74%Cor e Forma:SolidPeso molecular:629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€N-Desmethyl imatinib
CAS:N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.Fórmula:C28H29N7OPureza:98.60%Cor e Forma:Off-White To Pale-Yellow SolidPeso molecular:479.58Ref: TM-T11641
1mg92,00€5mg170,00€10mg319,00€25mg540,00€50mg777,00€100mg1.074,00€1mL*10mM (DMSO)178,00€Anti-CD117 Antibody (9H202)
Anti-CD117 Antibody (9H202) is an antibody targeting CD117. Anti-CD117 Antibody (9H202) can be used in ELISA, IHC, FCM.Cor e Forma:Odour LiquidLenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Cor e Forma:SolidPeso molecular:522.96Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Fórmula:C35H30N4O4Pureza:100% - 99.47%Cor e Forma:SolidPeso molecular:570.64Ref: TM-T3211
1mg51,00€5mg88,00€10mg126,00€25mg216,00€50mg328,00€100mg487,00€500mg1.093,00€1mL*10mM (DMSO)96,00€Anti-C-Kit Antibody-APC (1R766)
Anti-C-Kit Antibody-APC (1R766) is a APC-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-APC (1R766) can be used in FCM.Cor e Forma:Odour LiquidAnti-C-Kit Antibody-FITC (8E724)
Anti-C-Kit Antibody-FITC (8E724) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (8E724) can be used in FCM.Cor e Forma:Odour Liquidc-Kit-IN-3
CAS:c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).Fórmula:C26H20ClF3N2O4Pureza:99.43%Cor e Forma:SolidPeso molecular:516.9Ref: TM-T10651
1mg87,00€5mg162,00€10mg254,00€25mg419,00€50mg562,00€100mg787,00€500mg1.578,00€1mL*10mM (DMSO)334,00€Dovitinib lactate
CAS:Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Fórmula:C24H27FN6O4Pureza:98.44% - 99.54%Cor e Forma:SolidPeso molecular:482.51Ref: TM-T7104
5mg51,00€10mg79,00€25mg129,00€50mg213,00€100mg358,00€200mg535,00€500mg843,00€1mL*10mM (DMSO)57,00€CD117 Protein, Mouse, Recombinant (His)
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Cor e Forma:Lyophilized PowderPeso molecular:56.63 kDa (predicted). Due to glycosylation, the protein migrates to 75-100 kDa based on Tris-Bis PAGE result.Avapritinib
CAS:Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.Fórmula:C26H27FN10Pureza:96.59% - 99.7%Cor e Forma:SolidPeso molecular:498.56Ref: TM-T5109
1mg88,00€5mg187,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€500mg2.072,00€1mL*10mM (DMSO)205,00€AMG-25
CAS:AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Fórmula:C23H17N5O2Pureza:98.16%Cor e Forma:SolidPeso molecular:395.41c-Kit Protein, Human, Recombinant (aa 50-190, His)
c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:17.9 kDa (predicted); 18 kDa (reducing conditions)c-Kit Protein, Mouse, Recombinant (hFc)
c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:82.5 kDa (predicted); 100-110 kDa (reducing condition, due to glycosylation)Anti-C-Kit Antibody-PE (7P530)
Anti-C-Kit Antibody-PE (7P530) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (7P530) can be used in FCM.Cor e Forma:Odour LiquidCabozantinib
CAS:Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Fórmula:C28H24FN3O5Pureza:99.59% - 99.88%Cor e Forma:SolidPeso molecular:501.51Anti-C-Kit Antibody-FITC (7P530)
Anti-C-Kit Antibody-FITC (7P530) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (7P530) can be used in FCM.Cor e Forma:Odour LiquidSU14813
CAS:SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.Fórmula:C23H27FN4O4Pureza:99.72%Cor e Forma:SolidPeso molecular:442.48Tyrphostin AG1296
CAS:Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.Fórmula:C16H14N2O2Pureza:99.66% - 99.68%Cor e Forma:SolidPeso molecular:266.29Ref: TM-T6711
2mg40,00€5mg58,00€10mg90,00€25mg180,00€50mg279,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)81,00€
