Hedgehog/Smoothened
A via de sinalização Hedgehog/Smoothened é uma via crucial relacionada aos GPCRs, envolvida no desenvolvimento embrionário, regeneração de tecidos e manutenção de células-tronco. Smoothened (SMO) é uma proteína transmembrana chave que transduz sinais dos ligantes Hedgehog (Hh) para ativar cascatas de sinalização a jusante. A desregulação da via Hedgehog/Smoothened está implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um alvo significativo para intervenção terapêutica. Na CymitQuimica, oferecemos uma gama de moduladores de alta qualidade para a via Hedgehog/Smoothened para apoiar sua pesquisa em biologia do desenvolvimento, oncologia e medicina regenerativa.
Produtos da "Hedgehog/Smoothened"
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SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.77%Cor e Forma:SolidPeso molecular:526.52SAG dihydrochloride
CAS:SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.Fórmula:C28H30Cl3N3OSPureza:100%Cor e Forma:SoildPeso molecular:562.98Cyclopamine
CAS:Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.Fórmula:C27H41NO2Pureza:98.31% - 99.66%Cor e Forma:White Crystalline SolidPeso molecular:411.62Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:97.10% - 98.54%Cor e Forma:SolidPeso molecular:358.18Ref: TM-T3156
2mg42,00€5mg59,00€10mg85,00€25mg168,00€50mg235,00€100mg331,00€200mg492,00€1mL*10mM (DMSO)69,00€CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.Fórmula:C31H43ClN4O5Pureza:95.22%Cor e Forma:SolidPeso molecular:587.15ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Fórmula:C18H12F3N5OPureza:99.19%Cor e Forma:SolidPeso molecular:371.32Ref: TM-T14188
1mg64,00€5mg140,00€10mg212,00€25mg353,00€50mg500,00€100mg658,00€200mg905,00€1mL*10mM (DMSO)156,00€HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFórmula:C24H23ClN4O3Pureza:95.73%Cor e Forma:SolidPeso molecular:450.92Ref: TM-T3460
1mg52,00€5mg97,00€10mg178,00€25mg379,00€50mg645,00€100mg1.026,00€1mL*10mM (DMSO)110,00€Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Fórmula:C21H22N6OPureza:98.72%Cor e Forma:SolidPeso molecular:374.44SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Fórmula:C25H25F4N5O2Pureza:98.64%Cor e Forma:SolidPeso molecular:503.49Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Fórmula:C22H23F2N3O2SPureza:99.49%Cor e Forma:SolidPeso molecular:431.5SANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Fórmula:C26H26ClN3O4Pureza:99.23%Cor e Forma:SolidPeso molecular:479.96SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Fórmula:C16H24BrClN2OPureza:100%Cor e Forma:SolidPeso molecular:375.73CUR61414
CAS:CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Fórmula:C31H42N4O5Pureza:97.34% - 98.00%Cor e Forma:SolidPeso molecular:550.69Ref: TM-T15019
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg550,00€100mg787,00€1mL*10mM (DMSO)123,00€Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Fórmula:C28H26ClF2N3OSPureza:98.61%Cor e Forma:SolidPeso molecular:526.04Ref: TM-T24754
1mg127,00€5mg305,00€10mg472,00€25mg782,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)354,00€SAG
CAS:SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.Fórmula:C28H28ClN3OSPureza:98.16% - 98.88%Cor e Forma:SolidPeso molecular:490.06Ref: TM-T1779
1mg51,00€2mg71,00€5mg96,00€10mg153,00€25mg274,00€50mg376,00€100mg557,00€200mg797,00€500mg1.188,00€1mL*10mM (DMSO)97,00€RU-SKI 43
CAS:RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits Gli-1, Akt, mTOR pathways.Fórmula:C22H30N2O2SPureza:99.78%Cor e Forma:SolidPeso molecular:386.55Tolnaftate
CAS:Tolnaftate (NP-27) is a synthetic antifungal agent.Fórmula:C19H17NOSPureza:98.85%Cor e Forma:White PowderPeso molecular:307.41SAG 21k
CAS:SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.Fórmula:C29H28ClF2N3O2SPureza:99.51%Cor e Forma:SolidPeso molecular:556.07HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Fórmula:C27H29NO6Pureza:94.4%Cor e Forma:SolidPeso molecular:463.52Ref: TM-T22089
1mg47,00€2mg60,00€5mg92,00€10mg135,00€25mg217,00€50mg324,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)107,00€SANT-1
CAS:SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).Fórmula:C23H27N5Pureza:100% - 99.98%Cor e Forma:SolidPeso molecular:373.49
