Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
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Produtos da "Sinalização PI3K/Akt/mTOR"
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CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Fórmula:C21H24ClN5O3S2Pureza:97.8%Cor e Forma:SolidPeso molecular:494.03Ref: TM-T10804
1mg92,00€5mg216,00€10mg329,00€25mg593,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)235,00€5-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFórmula:C16H10IN3O2Cor e Forma:SolidPeso molecular:403.17EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Cor e Forma:Odour SolidPI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Fórmula:C22H25N3O5S2Pureza:99.76%Cor e Forma:SolidPeso molecular:475.58Ref: TM-T12468
1mg80,00€5mg164,00€10mg255,00€25mg420,00€50mg562,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)167,00€BI-4020
CAS:BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Fórmula:C30H38N8O2Pureza:100.00% - 98.44%Cor e Forma:SolidPeso molecular:542.68Ref: TM-T10534
1mg170,00€5mg398,00€10mg568,00€25mg848,00€50mg1.130,00€100mg1.510,00€200mg2.062,00€1mL*10mM (DMSO)472,00€Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.01% - 99.36%Cor e Forma:SolidPeso molecular:270.29Ref: TM-T7014
1mg38,00€2mg49,00€5mg79,00€10mg124,00€25mg240,00€50mg384,00€100mg560,00€1mL*10mM (DMSO)79,00€CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFórmula:C26H29N5O2Pureza:98.23%Cor e Forma:SolidPeso molecular:443.54Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Cor e Forma:Odour LiquidEGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.Fórmula:C30H20N6OSPureza:98%Cor e Forma:SolidPeso molecular:512.58YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Fórmula:C21H21FN2OPureza:98%Cor e Forma:SolidPeso molecular:336.4CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:98.81% - 99.87%Cor e Forma:SolidPeso molecular:377.42Ref: TM-T2619
1mg64,00€2mg96,00€5mg144,00€10mg227,00€25mg420,00€50mg622,00€100mg885,00€500mg1.786,00€GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.Fórmula:C9H6BrNOPureza:99.58%Cor e Forma:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05Rilematovir
CAS:Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Fórmula:C21H20ClF3N4O3SPureza:99.82%Cor e Forma:SolidPeso molecular:500.92EGFR-IN-133
CAS:EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Fórmula:C27H29F2N7O3Cor e Forma:SolidPeso molecular:537.56P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFórmula:C9H8ClN3OPureza:99.95%Cor e Forma:SolidPeso molecular:209.63Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Fórmula:C14H12O5Pureza:99.85% - 99.95%Cor e Forma:Light Yellow CrystallinePeso molecular:260.24TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFórmula:C18H14N4O2Pureza:98.02% - 99.13%Cor e Forma:SolidPeso molecular:318.331-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Fórmula:C15H10BrN3OPureza:99.6%Cor e Forma:Tan SolidPeso molecular:328.16Ref: TM-T6358
1mg79,00€2mg99,00€5mg188,00€10mg311,00€25mg560,00€50mg800,00€100mg1.093,00€500mg2.175,00€1mL*10mM (DMSO)187,00€MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Fórmula:C17H21N7O4Pureza:100% - 99.6%Cor e Forma:SolidPeso molecular:387.39Depatuxizumab
CAS:Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograftPureza:98%Cor e Forma:Liquid
