PDK
Os inibidores da piruvato desidrogenase quinase (PDK) têm como alvo a enzima PDK, que regula a atividade do complexo da piruvato desidrogenase (PDC) e desempenha um papel no controle metabólico e na apoptose. Ao inibir a PDK, esses compostos alteram o metabolismo celular da glicólise para a fosforilação oxidativa, o que pode induzir a apoptose em células cancerígenas que dependem da glicólise aeróbica (efeito Warburg) para sobreviver. Os inibidores de PDK são valiosos na pesquisa do metabolismo do câncer e no desenvolvimento terapêutico. Na CymitQuimica, fornecemos inibidores de PDK de alta qualidade para apoiar sua pesquisa em metabolismo do câncer, apoptose e bioenergética celular.
Produtos da "PDK"
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11 produtos desta categoria.
RS1-PDK1 inhibitor
CAS:RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.Fórmula:C15H9ClN2O2S3Pureza:98%Cor e Forma:SolidPeso molecular:380.89PS47
CAS:PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.Fórmula:C17H15ClO2Pureza:99.09%Cor e Forma:SolidPeso molecular:286.75Ref: TM-T24677
5mg46,00€10mg65,00€25mg123,00€50mg187,00€100mg309,00€200mg435,00€1mL*10mM (DMSO)65,00€Osu03012
CAS:Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.Fórmula:C26H19F3N4OPureza:97.95% - 99.22%Cor e Forma:SolidPeso molecular:460.45Ref: TM-T2466
2mg37,00€5mg51,00€10mg87,00€25mg143,00€50mg264,00€100mg349,00€200mg454,00€500mg742,00€1mL*10mM (DMSO)51,00€PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Fórmula:C15H9ClN2O2S3Pureza:98%Cor e Forma:SolidPeso molecular:380.89M77976
CAS:M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.Fórmula:C17H16N2O3Pureza:99.80%Cor e Forma:SolidPeso molecular:296.32PS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Fórmula:C14H13NO6SPureza:99.01%Cor e Forma:SolidPeso molecular:323.32MP7
CAS:MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Fórmula:C28H22F2N4O4Pureza:99.45% - 99.84%Cor e Forma:SolidPeso molecular:516.5PS 48
CAS:PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).Fórmula:C17H15ClO2Pureza:98.37% - ≥95%Cor e Forma:SolidPeso molecular:286.75GSK2334470
CAS:GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.Fórmula:C25H34N8OPureza:99.04% - 99.87%Cor e Forma:SolidPeso molecular:462.596-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFórmula:C9H6BrN3OPureza:98.81%Cor e Forma:SolidPeso molecular:252.07PS210
CAS:PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.Fórmula:C19H15F3O5Pureza:99.78%Cor e Forma:SolidPeso molecular:380.31Ref: TM-T16670
1mg37,00€2mg52,00€5mg74,00€10mg107,00€25mg197,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)85,00€
![6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT77685.webp&w=3840&q=75)
