ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Produtos da "ATM/ATR"
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ATM Inhibitor-11
CAS:ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Fórmula:C27H33FN6O2Cor e Forma:SolidPeso molecular:492.59ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Fórmula:C27H36N6O3Pureza:98%Cor e Forma:SolidPeso molecular:492.61ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Fórmula:C25H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:448.56KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Fórmula:C29H32N4O4S2Pureza:99.10%Cor e Forma:SolidPeso molecular:564.72AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Fórmula:C24H28N4O3Pureza:98.01%Cor e Forma:SolidPeso molecular:420.5Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Fórmula:C23H24O8Pureza:95.84% - 99.76%Cor e Forma:White SolidPeso molecular:428.43A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFórmula:C27H28N6OPureza:98%Cor e Forma:SolidPeso molecular:452.55Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFórmula:C20H22ClN7OPureza:99.03%Cor e Forma:SolidPeso molecular:411.89Ref: TM-T10468
1mg37,00€5mg88,00€10mg120,00€25mg235,00€50mg349,00€100mg497,00€200mg683,00€1mL*10mM (DMSO)96,00€ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFórmula:C26H34N6O2Pureza:98%Cor e Forma:SolidPeso molecular:462.59ATR-IN-24
CAS:ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].Fórmula:C23H26N6O2Pureza:98%Cor e Forma:SolidPeso molecular:418.49ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Fórmula:C18H24N6O2SPureza:100% - 99.76%Cor e Forma:SolidPeso molecular:388.49Ref: TM-T85731
1mg70,00€5mg154,00€10mg210,00€25mg376,00€50mg533,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)166,00€Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Fórmula:C25H29F2N9O3Pureza:99.52%Cor e Forma:SolidPeso molecular:541.55Ref: TM-T10407
1mg134,00€5mg321,00€10mg537,00€25mg1.074,00€50mg1.491,00€100mg2.242,00€1mL*10mM (DMSO)383,00€KU-60019
CAS:KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).Fórmula:C30H33N3O5SPureza:97.15% - 98.05%Cor e Forma:SolidPeso molecular:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Fórmula:C18H16N4O3SPureza:99.26% - 99.97%Cor e Forma:SolidPeso molecular:368.41Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFórmula:C23H21FN6O3Pureza:99.9%Cor e Forma:SolidPeso molecular:448.45Ref: TM-T62684
1mg130,00€2mg187,00€5mg311,00€10mg533,00€25mg1.035,00€50mg1.730,00€100mg2.680,00€1mL*10mM (DMSO)344,00€ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SCor e Forma:SolidPeso molecular:610.80ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Fórmula:C30H22N4O2Pureza:97.76%Cor e Forma:SolidPeso molecular:470.52Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:98.93%Cor e Forma:SolidPeso molecular:414.45
