mTOR
Os inibidores de mTOR são compostos que inibem a atividade do Alvo da Rapamicina em Mamíferos (mTOR), um regulador central do crescimento celular, proliferação, metabolismo e sobrevivência. A via de sinalização mTOR é frequentemente alterada em casos de câncer e outras doenças, tornando o mTOR um alvo crítico para intervenções terapêuticas. Inibidores de mTOR são amplamente utilizados em pesquisas relacionadas ao câncer, envelhecimento e distúrbios metabólicos. Na CymitQuimica, oferecemos uma variedade de inibidores de mTOR para apoiar sua pesquisa em transdução de sinais, oncologia e desenvolvimento terapêutico.
Produtos da "mTOR"
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MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Fórmula:C26H30N6O3Pureza:99.76%Cor e Forma:SolidPeso molecular:474.55Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFórmula:C15H12N2O3Pureza:99.26%Cor e Forma:SolidPeso molecular:268.27Ref: TM-T8649
1mg93,00€2mg120,00€5mg187,00€10mg315,00€25mg567,00€50mg810,00€100mg1.111,00€500mg2.232,00€1mL*10mM (DMSO)202,00€Rapamycin
CAS:Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.Fórmula:C51H79NO13Pureza:97.08% - 99.03%Cor e Forma:Yellow SolidPeso molecular:914.17Ref: TM-T1537
1g283,00€10mg35,00€25mg48,00€50mg52,00€100mg69,00€200mg106,00€500mg188,00€1mL*10mM (DMSO)50,00€CC214-1
CAS:CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.Fórmula:C20H21N7O2Pureza:97.87%Cor e Forma:SolidPeso molecular:391.43WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Fórmula:C24H29N7O5Pureza:97.86% - 99.61%Cor e Forma:SolidPeso molecular:495.53Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFórmula:C32H41N9O4Pureza:98% - 99.48%Cor e Forma:SolidPeso molecular:615.73Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Cor e Forma:SolidPeso molecular:505.5FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Fórmula:C20H26N8OPureza:98.34% - 98.80%Cor e Forma:SolidPeso molecular:394.47CC-115
CAS:CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).Fórmula:C16H16N8OPureza:86.79% - 99.22%Cor e Forma:SolidPeso molecular:336.35Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.01% - 99.36%Cor e Forma:SolidPeso molecular:270.29Ref: TM-T7014
1mg38,00€2mg49,00€5mg79,00€10mg124,00€25mg240,00€50mg384,00€100mg560,00€1mL*10mM (DMSO)79,00€NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg42,00€5mg64,00€10mg93,00€25mg168,00€50mg245,00€100mg375,00€200mg533,00€1mL*10mM (DMSO)88,00€Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Fórmula:C26H46N2OPureza:97.78% - 98%Cor e Forma:SolidPeso molecular:402.66Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Fórmula:C25H19BrCl2N2O3SPureza:99.72%Cor e Forma:SolidPeso molecular:578.3Ref: TM-T16741
1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg945,00€100mg1.596,00€1mL*10mM (DMSO)47,00€JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Fórmula:C17H14Cl2FN3OSPureza:98.87%Cor e Forma:SolidPeso molecular:398.28Ref: TM-T11728
1mg95,00€5mg202,00€10mg344,00€25mg630,00€50mg945,00€100mg1.264,00€1mL*10mM (DMSO)224,00€Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Fórmula:C25H30N6O3Pureza:97.08% - 99.06%Cor e Forma:SolidPeso molecular:462.54Ref: TM-T1961
1mg37,00€5mg74,00€10mg117,00€25mg173,00€50mg236,00€100mg378,00€200mg558,00€1mL*10mM (DMSO)84,00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Cor e Forma:SolidPeso molecular:406.48Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.Fórmula:C23H18N4O3SPureza:98.24%Cor e Forma:SolidPeso molecular:430.48Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:99.54% - 99.92%Cor e Forma:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg48,00€5mg120,00€10mg170,00€25mg283,00€50mg430,00€100mg620,00€1mL*10mM (DMSO)170,00€
