mTOR
Os inibidores de mTOR são compostos que inibem a atividade do Alvo da Rapamicina em Mamíferos (mTOR), um regulador central do crescimento celular, proliferação, metabolismo e sobrevivência. A via de sinalização mTOR é frequentemente alterada em casos de câncer e outras doenças, tornando o mTOR um alvo crítico para intervenções terapêuticas. Inibidores de mTOR são amplamente utilizados em pesquisas relacionadas ao câncer, envelhecimento e distúrbios metabólicos. Na CymitQuimica, oferecemos uma variedade de inibidores de mTOR para apoiar sua pesquisa em transdução de sinais, oncologia e desenvolvimento terapêutico.
Produtos da "mTOR"
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PP121
CAS:PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Fórmula:C17H17N7Pureza:99.19% - 99.67%Cor e Forma:SolidPeso molecular:319.36DMH-25
CAS:DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.Fórmula:C15H8Br3NO3Pureza:99.26%Cor e Forma:SolidPeso molecular:489.94Ref: TM-T8569
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)212,00€25(R,S)-Ruscogenin
CAS:25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Fórmula:C27H42O4Pureza:99.32% - 99.89%Cor e Forma:SolidPeso molecular:430.62DS-7423
CAS:DS-7423: a dual PI3K/mTOR inhibitor; IC50s-PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Fórmula:C22H27F3N10O2Pureza:99.68%Cor e Forma:SolidPeso molecular:520.51Ref: TM-T36083
1mg127,00€5mg283,00€10mg432,00€25mg707,00€50mg938,00€100mg1.378,00€1mL*10mM (DMSO)321,00€Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Fórmula:C35H58N6O9Pureza:98.63%Cor e Forma:SolidPeso molecular:706.87Palomid 529
CAS:Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Fórmula:C24H22O6Pureza:98.40% - 98.59%Cor e Forma:SolidPeso molecular:406.43PKCβ inhibitor 1
CAS:PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Fórmula:C24H21N5O2Pureza:99.33%Cor e Forma:SolidPeso molecular:411.46Ref: TM-T8376
1mg154,00€5mg424,00€10mg605,00€25mg920,00€50mg1.216,00€100mg1.673,00€200mg2.252,00€500µg93,00€1mL*10mM (DMSO)401,00€mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFórmula:C21H23N5O2SPureza:99.53%Cor e Forma:SoildPeso molecular:409.5SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Cor e Forma:SolidPeso molecular:336.15Ref: TM-T8719
1mg46,00€5mg93,00€10mg140,00€25mg240,00€50mg363,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)99,00€KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:98.98%Cor e Forma:SolidPeso molecular:528.61mTOR inhibitor-8
CAS:mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.Fórmula:C24H19ClN4OSPureza:98.11%Cor e Forma:SolidPeso molecular:446.95Ref: TM-T36316
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg588,00€100mg944,00€1mL*10mM (DMSO)116,00€Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.Cor e Forma:Odour LiquidSalidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Fórmula:C14H20O7Pureza:97.81%Cor e Forma:Red-Brown Fine PowderPeso molecular:300.3ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Fórmula:C30H22N4O2Pureza:97.76%Cor e Forma:SolidPeso molecular:470.52XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Cor e Forma:SolidPeso molecular:455.5(+)-Usnic acid
CAS:(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Fórmula:C18H16O7Pureza:97.61%Cor e Forma:SolidPeso molecular:344.32Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Fórmula:C15H15N7OPureza:100% - 99.67%Cor e Forma:SolidPeso molecular:309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€1mL*10mM (DMSO)88,00€GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Fórmula:C18H22N6O2SPureza:99.77%Cor e Forma:SolidPeso molecular:386.47Ref: TM-T22339
1mg85,00€2mg115,00€5mg188,00€10mg321,00€25mg509,00€50mg702,00€100mg932,00€200mg1.283,00€1mL*10mM (DMSO)205,00€GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:≥95% - ≥95%Cor e Forma:SolidPeso molecular:333.36
