Heterociclos com Nitrogénio (N)

Please enquire for more information about 2-(Bromomethyl)-3-(trifluoromethyl)pyridine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Contains up to 5 % Sodium Acetate by weight.

Please enquire for more information about 1-(Thien-2-ylsulfonyl)piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 4-Cyanopyridine is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, an antituberculotics. Preparation of the antihypertensive agent Pinacidil using the chemoselective and green oxidative rearrangement of an amidine and addition of an amine to a guanidine as the key step. Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking. Human L-xylulose reductase (XR) is an enzyme of the glucuronic acid/uronate cycle of glucose metabolism with the possible target for treatment of the long-term complications of diabetes. References Waisser, K., et al.: Folia Pharmaceutica Universitatis Carolinae, 18, 31 (1995); Carbone, V., et al.: Bioorg. Med. Chem., 13, 301 (2004); Baeten, M., et al.: Adv. Synth. Catal., 358, 826 (2016)

1-(5-Isoquinolinesulfonyl)piperazine hydrochloride (1-ISOQ-PIP) is a chemical compound that has been shown to inhibit the growth of leukemia cells. It inhibits the expression of leukemia inhibitory factor, which may be due to its ability to introduce modifications into the sequence of DNA. 1-ISOQ-PIP also inhibits pluripotent stem cells and induces adipocyte differentiation. This substance can be used for cancer treatment by inhibiting the growth of leukemia cells and inducing differentiation.

2-Pyrimidinemethanol is a substrate analogue that is used as an experimental drug. It is an orally active molecule and has shown to decrease blood pressure in mice by acting on glutamic dehydrogenase, which is the enzyme responsible for the conversion of glutamate to 2-pyrimidinol. 2-Pyrimidinemethanol has been shown to be a potent inhibitor of peptidomimetic activity in humans. This drug may also be effective in treating sciatic nerve damage by inhibiting the enzyme that converts lysine to lysinoalanine.

Please enquire for more information about 4-Bromo-2,3,5-trifluoropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7-(Chloromethyl)-2-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Chloro-2-methoxypyridin-4-yl)boronic acid is a boronic acid that can be used in the synthesis of heteroaryl compounds. 5-Chloro-2-methoxypyridin-4-yl)boronic acid reacts with various electrophiles, such as bromides, to produce aryl ethers and esters. This compound can also be used to synthesize furyl derivatives through Suzuki cross coupling reactions. 5-Chloro-2-methoxypyridin-4-yl)boronic acid is an efficient reagent for the synthesis of a wide variety of organic compounds.

5H-Pyrrolo[2,3-b]pyrazine is an inhibitor of the enzyme nitric oxide synthase. It has been shown to inhibit the proliferation of skin cancer cells and to cause apoptosis in Hl-60 cells. 5H-Pyrrolo[2,3-b]pyrazine inhibits the production of prostaglandin E 2 and reduces inflammation by inhibiting the activation of macrophages. This compound has been used as a potential anti-cancer drug candidate for its ability to inhibit tumor growth and metastasis. 5H-Pyrrolo[2,3-b]pyrazine also inhibits the synthesis of fatty acids in liver cells, which may be due to its ability to reduce hepatic steatosis in laboratory animals.