Heterociclos com Nitrogénio (N)

2-Quinolinecarboxylic acid is an antibiotic that is used in the treatment of bacterial infections and has inhibitory properties. It has been shown to be a competitive inhibitor of the enzyme quinolinate phosphoribosyltransferase, which catalyzes the conversion of quinolinic acid to nicotinic acid. 2-Quinolinecarboxylic acid binds to the active site of the enzyme and prevents substrate binding, thereby blocking the production of nicotinic acid. This drug also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucur

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Niclosamide is a piperazine-type anthelmintic drug used to treat hepatic steatosis. It has been shown to improve insulin resistance and mitochondrial membrane potential, which may be due to its ability to uncouple oxidative phosphorylation in mitochondria. Niclosamide also has low oral bioavailability and is poorly absorbed from the gastrointestinal tract. This drug is repurposed for treating hyperlipidemia and metabolic syndrome with good safety profile. Reaction time of niclosamide is fast, with an apical half-life of 4 hours.

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Piperazine is a nitrogenous organic compound with a six-membered ring. It has been shown to be an inhibitor of some viruses, including influenza virus, herpes virus, and human immunodeficiency virus type 1 (HIV-1). Piperazine has been shown to inhibit the replication of both RNA and DNA viruses in vitro. This drug also inhibits the replication of hepatitis B virus in vitro and has been shown to have an inhibitory effect on the replication of HIV-1 in vitro. Piperazine is not active against RNA or DNA viruses that use only reverse transcriptase for viral replication. The chemical structure of piperazine is similar to that of amines, which are known to have antiviral properties. Piperazine can be synthesized from benzaldehyde and ammonia by reaction with hydrochloric acid and sodium nitrate.

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1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as

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Indole is a nitrogen-containing heterocyclic aromatic organic compound. Copper chloride in the presence of trifluoroacetic acid and indole gives rise to an indolenine derivative, which reacts with nitrogen atoms to form a copper nitride. This reaction is used as a model system for biological properties of indole. Indolenine has been shown to have bone cancer prevention and treatment effects in mice, and may also be beneficial in autoimmune diseases and metabolic disorders, due to its ability to inhibit toll-like receptor signaling pathways. The wild-type strain has shown resistance to antibiotics, which can be overcome by using mutant strains that are resistant to antibiotic treatments.

2-(Boc-amino)-3-methylpyridine is a cytotoxic agent that has been shown to inhibit the proliferation of cancer cells. It is a potent cytotoxic agent that can be used to treat cancer. 2-(Boc-amino)-3-methylpyridine inhibits the growth of cancer cells by inhibiting the activity of B-Raf, a protein involved in cell proliferation and apoptosis. The anticancer properties are due to its ability to inhibit protein synthesis in cells by inhibiting the enzyme carbinolamine N-methyltransferase, which is required for the synthesis of methionine. 2-(Boc-amino)-3-methylpyridine also inhibits DNA and RNA synthesis in cells. This drug has been shown to have antiangiogenic effects, which may be due to its ability to inhibit vascular endothelial growth factor (VEGF) production. END>

2-Methyl-4-nitropyridine is an organic chemical compound with the formula C5H7N3O. It is a colorless or white solid that is soluble in water and polar organic solvents. 2-Methyl-4-nitropyridine has been shown to form nitroso, thiosemicarbazide, and nitrosothiol functionalities. This molecule can be used as a precursor for other compounds through hydrogenation reduction, nucleophilic substitution reactions, and electron transfer reactions. The n-oxide of 2-methylpyridine can be obtained by reacting with oxygen gas in the presence of light. Spectroscopic data indicate that this molecule has a hydrogen bond and some aromaticity due to its ring structure. 2-Methyl-4-nitropyridine has been found to reduce ethylene acetal under mild conditions.

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Applications N-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]Amine (cas# 147225-68-1) is a useful research chemical.

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2-Iodopyridine-3-carboxylic acid is a monoclonal antibody that binds to the tyrosine kinase domain of receptor proteins, which are involved in cellular signal transduction. It has been shown to inhibit tumor growth in mice with epithelial cancers, and is being investigated as a potential therapeutic for other cancers. 2-Iodopyridine-3-carboxylic acid can be used as an inhibitor compound to modulate the activity of the receptor protein. This inhibition leads to reduced cell proliferation and cancer cell death. The uptake of this drug into cells is enhanced by fluorine, which may be due to its structural similarity with 2-iodopyrimidine.

5-Nitro-pyridine-2-sulfonyl chloride is a chemical reagent that is used in the synthesis of various organic compounds. It is a versatile building block and can be used as an intermediate for the synthesis of other compounds. 5-Nitro-pyridine-2-sulfonyl chloride is also a reaction component in the synthesis of some pharmaceutical drugs, such as benzoic acid, which can be used to manufacture more complex compounds, such as antibiotics.

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2-(Bromomethyl)-6-(hydroxymethyl)pyridine is a linker that can be used to connect the hydrophobic anthracene chromophore and hydrophilic phosphoryl group. It has been shown to have catalytic activity with respect to photocleavage reactions, which may be due to its helical structure and interaction with the substrate. 2-Bromomethyl-6-(hydroxymethyl)pyridine can also be used as a linker in other chemical reactions, such as DNA synthesis or protein binding. The reactive nature of this compound makes it susceptible to thermal denaturation, so it should not be exposed to heat for long periods of time.

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6-Pyridin-4-yl-2H-pyridazin-3-one is a cardiotonic agent that has been shown to increase cardiac contractility in animals. It is an intermediate of the synthesis of other drugs such as sulfanilamide and hydralazine. 6-Pyridin-4yl-2H-pyridazin-3-one has also been used in the synthesis of other drugs, including sulfonylureas, which are used to treat diabetes mellitus. This compound is structurally related to hydrazine, which is a toxic substance with cardiotonic effects. 6-Pyridin-4yl-2Hpyridazin 3 one is effective at lowering blood pressure by blocking sodium channels in vascular smooth muscle cells and inhibiting calcium release from the sarcoplasmic reticulum in heart muscle cells.

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3-Hydroxypiperidine hydrochloride is an industrial chemical that is used in the synthesis of medicines. It is a nucleophile, and will react with electrophiles in a nucleophilic substitution reaction. 3-Hydroxypiperidine hydrochloride can be used for the synthesis of sulfinates, which are often used as medicine reagents. 3-Hydroxypiperidine hydrochloride has also been shown to be useful in the synthesis of five-membered heterocycles, such as diazepinones, from 2-aminoethanethiols.