Heterociclos com Nitrogénio (N)

Imidazo[1,2-a]pyridine-3-carboxylic acid is an ester with the chemical formula CHNO. It is a white crystalline solid that is soluble in water and ethanol. Imidazo[1,2-a]pyridine-3-carboxylic acid has been synthesized from pyridine-3-carboxylic acid by an efficient method that includes microwave irradiation in the presence of an ester. The disubstituted imidazo[1,2-a]pyridine carboxylate is a synthetic intermediate for other organic compounds.

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4,6-Dichloropyrazolo[3,4-d]pyrimidine is a synthetic nucleoside analog. It inhibits DNA synthesis by inhibiting the enzyme adenosine deaminase, which converts adenosine to inosine. This drug may also inhibit RNA synthesis and protein synthesis, although this has not been confirmed. The postulated mechanism of action for 4,6-Dichloropyrazolo[3,4-d]pyrimidine is that it can be phosphorylated to form a pyrimidine nucleotide analog and therefore competes with natural nucleosides for incorporation into the growing DNA strand. This leads to arrest of the cell cycle at the G2/M checkpoint.

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4,6-Dichloro-2-methylsulfonylpyrimidine (DCP) is a chemical compound that has been used in the synthesis of other drugs. This drug has been found to have constant optical properties and a molecular electrostatic potential that is intermediate between anilines and amines. It is electron deficient and nucleophilic with a phosphate monohydrate crystal structure. DCP has also been shown to be effective in clinical development for the treatment of depression. Structural analysis by x-ray diffraction showed that this compound possesses strong hydrogen bonding interactions with amines, which may explain its antidepressant activity.

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