Heterociclos com Nitrogénio (N)

4-Amino-3-mercaptopyridine is an acid hydrazide that reacts with formic acid to produce a pyridinium salt and formate. This compound has been used as a reagent in the synthesis of pyridine derivatives, such as 4-aminopyridine. It can also be used to synthesize other compounds, such as formamide and anhydride. 4-Amino-3-mercaptopyridine is used in the production of organic acids.

Diminazene is a medicine used to treat acute and chronic babesiosis. It is an oral prodrug that is metabolized to 2-benzyloxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (DMBP), its active form. Diminazene inhibits the synthesis of surface proteins in Babesia microti and other protozoa by targeting the polymerase chain reaction. It also has antimicrobial effects against bacteria and fungi. The drug is effective in chemotherapy for infectious diseases such as tuberculosis, when given at high doses over a long period of time. Diminazene does not have any side effects on uninfected animals or humans with normal levels of lipoproteins.

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2-Amino-4-hydroxy-6-ethylpyrimidine is a cinnamic acid derivative that is used as a sunscreen. This compound absorbs UV radiation and may also stabilize the sunscreens to prevent degradation. It is structurally similar to phenylephrine hydrochloride, with the only difference being an amino group on the 2 position of the pyrimidine ring. This compound has been shown to have viscosity decreasing properties, which can be attributed to its ability to denature proteins found in skin oils. The chloride ion pairs with the hydroxyl group on the 2 position of the pyrimidine ring and forms a negatively charged ion pair. The cationic form of this compound may bind with an anionic surfactant such as dodecyl or cetylpyridinium chloride, which would increase its solubility in water and allow it to be used as a sunscreen in cosmetics.

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4-Aminopiperidin-1-carboxylic acid ethyl ester is a structural modification of the amide antibiotic piperacillin. This compound binds to 5-HT2A receptors and has been shown to have antibacterial activity against Gram-positive bacteria, such as Enterococcus faecalis. 4-Aminopiperidin-1-carboxylic acid ethyl ester has also been shown to have antimalarial activity in mice. The pharmacophore for 4-aminopiperidin-1 carboxylic acid ethyl ester is a linker with a mononuclear carboxylate group. Optimization studies have led to the synthesis of analogs with altered physicochemical properties, which may increase the compound’s stability and bioavailability.